The Physiological Link between Metabolic Rate Depression and Tau Phosphorylation in Mammalian
Abnormal phosphorylation and aggregation of tau protein are hallmarks of a variety of neurological disorders, including Alzheimer’s disease (AD). Increased tau phosphorylation is assumed to represent an early event in pathogenesis and a pivotal aspect for aggregation and formation of neurofibrillary...
Main Authors: | , , , , , , |
---|---|
Other Authors: | |
Format: | Text |
Language: | English |
Subjects: | |
Online Access: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.292.6047 |
id |
ftciteseerx:oai:CiteSeerX.psu:10.1.1.292.6047 |
---|---|
record_format |
openpolar |
spelling |
ftciteseerx:oai:CiteSeerX.psu:10.1.1.292.6047 2023-05-15T15:09:04+02:00 The Physiological Link between Metabolic Rate Depression and Tau Phosphorylation in Mammalian Jens T. Stieler Torsten Bullmann Franziska Kohl Øivind Tøien Martina K. Brückner Brian M. Barnes Thomas Arendt The Pennsylvania State University CiteSeerX Archives application/zip http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.292.6047 en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.292.6047 Metadata may be used without restrictions as long as the oai identifier remains attached to it. ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/14/71/PLoS_One_2011_Jan_18_6(1)_e14530.tar.gz text ftciteseerx 2016-01-07T21:38:27Z Abnormal phosphorylation and aggregation of tau protein are hallmarks of a variety of neurological disorders, including Alzheimer’s disease (AD). Increased tau phosphorylation is assumed to represent an early event in pathogenesis and a pivotal aspect for aggregation and formation of neurofibrillary tangles. However, the regulation of tau phosphorylation in vivo and the causes for its increased stage of phosphorylation in AD are still not well understood, a fact that is primarily based on the lack of adequate animal models. Recently we described the reversible formation of highly phosphorylated tau protein in hibernating European ground squirrels. Hence, mammalian hibernation represents a model system very well suited to study molecular mechanisms of both tau phosphorylation and dephosphorylation under in vivo physiological conditions. Here, we analysed the extent and kinetics of hibernation-state dependent tau phosphorylation in various brain regions of three species of hibernating mammals: arctic ground squirrels, Syrian hamsters and black bears. Overall, tau protein was highly phosphorylated in torpor states and phosphorylation levels decreased after arousal in all species. Differences between brain regions, hibernation-states and phosphosites were observed with respect to degree and kinetics of tau phosphorylation. Furthermore, we tested the phosphate net turnover of tau protein to analyse potential alterations in kinase and/or phosphatase activities during hibernation. Our results demonstrate that the hibernation-state dependent phosphorylation of tau protein is specifically regulated but involves, in addition, passive, temperature driven regulatory Text Arctic Unknown Arctic |
institution |
Open Polar |
collection |
Unknown |
op_collection_id |
ftciteseerx |
language |
English |
description |
Abnormal phosphorylation and aggregation of tau protein are hallmarks of a variety of neurological disorders, including Alzheimer’s disease (AD). Increased tau phosphorylation is assumed to represent an early event in pathogenesis and a pivotal aspect for aggregation and formation of neurofibrillary tangles. However, the regulation of tau phosphorylation in vivo and the causes for its increased stage of phosphorylation in AD are still not well understood, a fact that is primarily based on the lack of adequate animal models. Recently we described the reversible formation of highly phosphorylated tau protein in hibernating European ground squirrels. Hence, mammalian hibernation represents a model system very well suited to study molecular mechanisms of both tau phosphorylation and dephosphorylation under in vivo physiological conditions. Here, we analysed the extent and kinetics of hibernation-state dependent tau phosphorylation in various brain regions of three species of hibernating mammals: arctic ground squirrels, Syrian hamsters and black bears. Overall, tau protein was highly phosphorylated in torpor states and phosphorylation levels decreased after arousal in all species. Differences between brain regions, hibernation-states and phosphosites were observed with respect to degree and kinetics of tau phosphorylation. Furthermore, we tested the phosphate net turnover of tau protein to analyse potential alterations in kinase and/or phosphatase activities during hibernation. Our results demonstrate that the hibernation-state dependent phosphorylation of tau protein is specifically regulated but involves, in addition, passive, temperature driven regulatory |
author2 |
The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Jens T. Stieler Torsten Bullmann Franziska Kohl Øivind Tøien Martina K. Brückner Brian M. Barnes Thomas Arendt |
spellingShingle |
Jens T. Stieler Torsten Bullmann Franziska Kohl Øivind Tøien Martina K. Brückner Brian M. Barnes Thomas Arendt The Physiological Link between Metabolic Rate Depression and Tau Phosphorylation in Mammalian |
author_facet |
Jens T. Stieler Torsten Bullmann Franziska Kohl Øivind Tøien Martina K. Brückner Brian M. Barnes Thomas Arendt |
author_sort |
Jens T. Stieler |
title |
The Physiological Link between Metabolic Rate Depression and Tau Phosphorylation in Mammalian |
title_short |
The Physiological Link between Metabolic Rate Depression and Tau Phosphorylation in Mammalian |
title_full |
The Physiological Link between Metabolic Rate Depression and Tau Phosphorylation in Mammalian |
title_fullStr |
The Physiological Link between Metabolic Rate Depression and Tau Phosphorylation in Mammalian |
title_full_unstemmed |
The Physiological Link between Metabolic Rate Depression and Tau Phosphorylation in Mammalian |
title_sort |
physiological link between metabolic rate depression and tau phosphorylation in mammalian |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.292.6047 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/14/71/PLoS_One_2011_Jan_18_6(1)_e14530.tar.gz |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.292.6047 |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
_version_ |
1766340308786741248 |