Analysis of PB2 protein from H9N2 and H5N1 avian flu virus
Influenza A viruses of subtype H9N2 are wide spread among poultry and other mammalian species. Crossing the species barrier from poultry to human occurred in recent years creating a pandemic of H9N2 virus. It is known that the pathogenicity of H9N2 is lower than H5N1. Nonetheless, it is important to...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.278.2980 2023-05-15T15:34:22+02:00 Analysis of PB2 protein from H9N2 and H5N1 avian flu virus Asad Ullah Khan The Pennsylvania State University CiteSeerX Archives application/zip http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.278.2980 en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.278.2980 Metadata may be used without restrictions as long as the oai identifier remains attached to it. ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ef/98/Bioinformation_2008_Sep_22_3(1)_41-46.tar.gz PB2 protein H5N1 H9N2 mutations N-myristoylation domain Background text ftciteseerx 2016-01-07T20:55:35Z Influenza A viruses of subtype H9N2 are wide spread among poultry and other mammalian species. Crossing the species barrier from poultry to human occurred in recent years creating a pandemic of H9N2 virus. It is known that the pathogenicity of H9N2 is lower than H5N1. Nonetheless, it is important to establish the molecular functions of H9N2 viral proteins. We studied mutations in the polymerase protein PB2 of H9N2 from different strains and compared it with the highly pathogenic H5N1. The mutation M294T was found to be important in the N-myristoylation domain of Ck/UP/2573/India/04(H9N2) isolate. Prediction of secondary structures and PROSITE motif assignments were performed for PB2 to gain functional insight. Subsequently, the effect of mutations in secondary structures among strains is discussed. Text Avian flu Unknown |
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PB2 protein H5N1 H9N2 mutations N-myristoylation domain Background |
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PB2 protein H5N1 H9N2 mutations N-myristoylation domain Background Asad Ullah Khan Analysis of PB2 protein from H9N2 and H5N1 avian flu virus |
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PB2 protein H5N1 H9N2 mutations N-myristoylation domain Background |
description |
Influenza A viruses of subtype H9N2 are wide spread among poultry and other mammalian species. Crossing the species barrier from poultry to human occurred in recent years creating a pandemic of H9N2 virus. It is known that the pathogenicity of H9N2 is lower than H5N1. Nonetheless, it is important to establish the molecular functions of H9N2 viral proteins. We studied mutations in the polymerase protein PB2 of H9N2 from different strains and compared it with the highly pathogenic H5N1. The mutation M294T was found to be important in the N-myristoylation domain of Ck/UP/2573/India/04(H9N2) isolate. Prediction of secondary structures and PROSITE motif assignments were performed for PB2 to gain functional insight. Subsequently, the effect of mutations in secondary structures among strains is discussed. |
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The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Asad Ullah Khan |
author_facet |
Asad Ullah Khan |
author_sort |
Asad Ullah Khan |
title |
Analysis of PB2 protein from H9N2 and H5N1 avian flu virus |
title_short |
Analysis of PB2 protein from H9N2 and H5N1 avian flu virus |
title_full |
Analysis of PB2 protein from H9N2 and H5N1 avian flu virus |
title_fullStr |
Analysis of PB2 protein from H9N2 and H5N1 avian flu virus |
title_full_unstemmed |
Analysis of PB2 protein from H9N2 and H5N1 avian flu virus |
title_sort |
analysis of pb2 protein from h9n2 and h5n1 avian flu virus |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.278.2980 |
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Avian flu |
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Avian flu |
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ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ef/98/Bioinformation_2008_Sep_22_3(1)_41-46.tar.gz |
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http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.278.2980 |
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Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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