Umbilical cord mercury concentration as biomarker of prenatal exposure to methylmercury. Environ Health Perspect 113:905–908
Biomarkers are often applied to assess prenatal exposure to methylmercury in research and surveillance. In a prospective study in the Faroe Islands, the main exposure biomarkers were the mercury concentrations in cord blood and maternal hair obtained at parturition. We have now supplemented these ex...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.276.7966 2023-05-15T16:10:53+02:00 Umbilical cord mercury concentration as biomarker of prenatal exposure to methylmercury. Environ Health Perspect 113:905–908 Esben Budtz-jørgensen Poul J. Jørgensen Pál Weihe The Pennsylvania State University CiteSeerX Archives 2005 application/zip http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.7966 en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.7966 Metadata may be used without restrictions as long as the oai identifier remains attached to it. ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/7d/70/Environ_Health_Perspect_2005_Jul_31_113(7)_905-908.tar.gz Key words biomarker exposure assessment food contamination hair analysis text 2005 ftciteseerx 2016-01-07T20:51:58Z Biomarkers are often applied to assess prenatal exposure to methylmercury in research and surveillance. In a prospective study in the Faroe Islands, the main exposure biomarkers were the mercury concentrations in cord blood and maternal hair obtained at parturition. We have now supplemented these exposure biomarkers with mercury analyses of umbilical cord tissue from 447 births. In particular, when expressed in relation to the dry weight of the tissue, the cord mercury concentration correlated very well with that in cord blood. Structural equation model analysis showed that these two biomarkers have average total imprecision of about 30%, which is much higher than the laboratory error. The imprecision of the dry-weight–based concentration was lower than that of the wet-weight–based parameter, and it was intermediate between those of the cord blood and the hair biomarkers. In agreement with this finding, regression analyses showed that the dry-weight cord mercury concentration was almost as good a predictor of methylmercury-associated neuropsychologic deficits at 7 years of age as was the cord-blood mercury concentration. Cord mercury analysis can therefore be used as a valid measure of prenatal methylmercury exposure, but appropriate adjustment for the imprecision should be considered. Text Faroe Islands Unknown Faroe Islands |
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Key words biomarker exposure assessment food contamination hair analysis |
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Key words biomarker exposure assessment food contamination hair analysis Esben Budtz-jørgensen Poul J. Jørgensen Pál Weihe Umbilical cord mercury concentration as biomarker of prenatal exposure to methylmercury. Environ Health Perspect 113:905–908 |
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Key words biomarker exposure assessment food contamination hair analysis |
description |
Biomarkers are often applied to assess prenatal exposure to methylmercury in research and surveillance. In a prospective study in the Faroe Islands, the main exposure biomarkers were the mercury concentrations in cord blood and maternal hair obtained at parturition. We have now supplemented these exposure biomarkers with mercury analyses of umbilical cord tissue from 447 births. In particular, when expressed in relation to the dry weight of the tissue, the cord mercury concentration correlated very well with that in cord blood. Structural equation model analysis showed that these two biomarkers have average total imprecision of about 30%, which is much higher than the laboratory error. The imprecision of the dry-weight–based concentration was lower than that of the wet-weight–based parameter, and it was intermediate between those of the cord blood and the hair biomarkers. In agreement with this finding, regression analyses showed that the dry-weight cord mercury concentration was almost as good a predictor of methylmercury-associated neuropsychologic deficits at 7 years of age as was the cord-blood mercury concentration. Cord mercury analysis can therefore be used as a valid measure of prenatal methylmercury exposure, but appropriate adjustment for the imprecision should be considered. |
author2 |
The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Esben Budtz-jørgensen Poul J. Jørgensen Pál Weihe |
author_facet |
Esben Budtz-jørgensen Poul J. Jørgensen Pál Weihe |
author_sort |
Esben Budtz-jørgensen |
title |
Umbilical cord mercury concentration as biomarker of prenatal exposure to methylmercury. Environ Health Perspect 113:905–908 |
title_short |
Umbilical cord mercury concentration as biomarker of prenatal exposure to methylmercury. Environ Health Perspect 113:905–908 |
title_full |
Umbilical cord mercury concentration as biomarker of prenatal exposure to methylmercury. Environ Health Perspect 113:905–908 |
title_fullStr |
Umbilical cord mercury concentration as biomarker of prenatal exposure to methylmercury. Environ Health Perspect 113:905–908 |
title_full_unstemmed |
Umbilical cord mercury concentration as biomarker of prenatal exposure to methylmercury. Environ Health Perspect 113:905–908 |
title_sort |
umbilical cord mercury concentration as biomarker of prenatal exposure to methylmercury. environ health perspect 113:905–908 |
publishDate |
2005 |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.7966 |
geographic |
Faroe Islands |
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Faroe Islands |
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Faroe Islands |
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Faroe Islands |
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ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/7d/70/Environ_Health_Perspect_2005_Jul_31_113(7)_905-908.tar.gz |
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http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.7966 |
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Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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