Children’s Health | Article
Polychlorinated biphenyls (PCBs) are food-chain contaminants that have been shown to induce adverse developmental effects in humans. In the course of an epidemiologic study established to investigate neurodevelopmental deficits induced by environmental PCB exposure in the Inuit population of norther...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.276.7013 2023-05-15T16:55:12+02:00 Children’s Health | Article Pierre Ayotte Gina Muckle Joseph L. Jacobson Ra W. Jacobson Éric Dewailly The Pennsylvania State University CiteSeerX Archives application/zip http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.7013 en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.7013 Metadata may be used without restrictions as long as the oai identifier remains attached to it. ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/2b/72/Environ_Health_Perspect_2003_Jul_111(9)_1253-1258.tar.gz text ftciteseerx 2016-01-07T20:51:35Z Polychlorinated biphenyls (PCBs) are food-chain contaminants that have been shown to induce adverse developmental effects in humans. In the course of an epidemiologic study established to investigate neurodevelopmental deficits induced by environmental PCB exposure in the Inuit population of northern Québec (Nunavik, Canada), we compared three biomarkers of prenatal exposure and models to predict PCB plasma concentration at 6 months postpartum. Concentrations of 14 PCB congeners were measured by high-resolution gas chromatography with electron capture detection in lipids extracted from maternal plasma, cord plasma, breast milk (collected at ~1 month postpartum), and 6-month-old infant plasma samples. Similar congener profiles were observed in all biologic samples, and PCB-153, the most abundant and persistent PCB congener, was strongly correlated with other frequently detected PCB congeners in all biologic media. When expressed on a lipid basis, maternal plasma, cord plasma, and milk concentrations of this congener were strongly intercorrelated, indicating that PCB concentration in any of these biologic media is a good indicator of prenatal exposure to PCBs. A multivariate model that included maternal PCB-153 plasma lipid concentration, breast-feeding duration, and the sum of two skin-fold thicknesses (an index of infant body fat mass) explained 72 % of PCB-153 plasma concentration variance at Text inuit Nunavik Unknown Canada Nunavik |
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Polychlorinated biphenyls (PCBs) are food-chain contaminants that have been shown to induce adverse developmental effects in humans. In the course of an epidemiologic study established to investigate neurodevelopmental deficits induced by environmental PCB exposure in the Inuit population of northern Québec (Nunavik, Canada), we compared three biomarkers of prenatal exposure and models to predict PCB plasma concentration at 6 months postpartum. Concentrations of 14 PCB congeners were measured by high-resolution gas chromatography with electron capture detection in lipids extracted from maternal plasma, cord plasma, breast milk (collected at ~1 month postpartum), and 6-month-old infant plasma samples. Similar congener profiles were observed in all biologic samples, and PCB-153, the most abundant and persistent PCB congener, was strongly correlated with other frequently detected PCB congeners in all biologic media. When expressed on a lipid basis, maternal plasma, cord plasma, and milk concentrations of this congener were strongly intercorrelated, indicating that PCB concentration in any of these biologic media is a good indicator of prenatal exposure to PCBs. A multivariate model that included maternal PCB-153 plasma lipid concentration, breast-feeding duration, and the sum of two skin-fold thicknesses (an index of infant body fat mass) explained 72 % of PCB-153 plasma concentration variance at |
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The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Pierre Ayotte Gina Muckle Joseph L. Jacobson Ra W. Jacobson Éric Dewailly |
spellingShingle |
Pierre Ayotte Gina Muckle Joseph L. Jacobson Ra W. Jacobson Éric Dewailly Children’s Health | Article |
author_facet |
Pierre Ayotte Gina Muckle Joseph L. Jacobson Ra W. Jacobson Éric Dewailly |
author_sort |
Pierre Ayotte |
title |
Children’s Health | Article |
title_short |
Children’s Health | Article |
title_full |
Children’s Health | Article |
title_fullStr |
Children’s Health | Article |
title_full_unstemmed |
Children’s Health | Article |
title_sort |
children’s health | article |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.7013 |
geographic |
Canada Nunavik |
geographic_facet |
Canada Nunavik |
genre |
inuit Nunavik |
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inuit Nunavik |
op_source |
ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/2b/72/Environ_Health_Perspect_2003_Jul_111(9)_1253-1258.tar.gz |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.7013 |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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1766046184859762688 |