Articles Concentration of Organochlorines in Human Brain, Liver, and Adipose Tissue Autopsy Samples from Greenland
Organochlorines are persistent lipophilic compounds that accumulate in Inuit people living in circumpolar countries. Organochlorines accumulate as a result of the Inuits ' large consumption of sea mammal fat; however, available data are limited to blood lipids, milk fat,.and adipose tissue. We...
Main Authors: | , , , , |
---|---|
Other Authors: | |
Format: | Text |
Language: | English |
Subjects: | |
Online Access: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.6802 |
id |
ftciteseerx:oai:CiteSeerX.psu:10.1.1.276.6802 |
---|---|
record_format |
openpolar |
spelling |
ftciteseerx:oai:CiteSeerX.psu:10.1.1.276.6802 2023-05-15T16:28:09+02:00 Articles Concentration of Organochlorines in Human Brain, Liver, and Adipose Tissue Autopsy Samples from Greenland Tric Dewailly Gert Mulvad Henning S. Pedersen Pierre Ayotte Jens C. Hansen The Pennsylvania State University CiteSeerX Archives application/zip http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.6802 en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.6802 Metadata may be used without restrictions as long as the oai identifier remains attached to it. ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/b5/36/Environ_Health_Perspect_1999_Oct_107(10)_823-828.tar.gz bhp ehpnetl text ftciteseerx 2016-01-07T20:51:27Z Organochlorines are persistent lipophilic compounds that accumulate in Inuit people living in circumpolar countries. Organochlorines accumulate as a result of the Inuits ' large consumption of sea mammal fat; however, available data are limited to blood lipids, milk fat,.and adipose tissue. We report results of organodorine determination in liver, brain, omental fat, and subcutaneous abdominal fat samples collected from deceased Greenlanders between 1992 and 1994. Eleven chlorinated pesticides and 14 polychlorinated biphenyl congeners were measured in tissue lipid extracts by high-resolution gas chromatography with electron capture detection. Mean concentrations of polychlorinated biphenyls, 2,2'-bis(4-chlorophenyl)-1,1-dichllcroethylene,,B-hexachlorocyloherane, heachlorobenzene, mires, transnonachlor, and oxychlordane in adipose tissue samples from Greenlanders were 3-34-fold higher than those measured using the same analytical method in samples from Canadians in Quebec City, Quebec. Brain lipids contained lower concentrations of all organochlorines than lipids etracted from other tissues. Organochiorine residue lewls in lipid extracts from liver, omental fat, and subcutaneous abdominal fat samples were similar, with the exception of i-hexachlorocydohexane, which reached a greater concentration in liver lipids than in lipids from both adipose tissues (4-fold; p < 0.05). Comparisons with available international data on adipose tissue levels reveal that the organochlorine body burden in the Inuit population of Greenland is presently among the highest resulting from environmental exposure. Text Greenland greenlander* inuit inuits Unknown Greenland |
institution |
Open Polar |
collection |
Unknown |
op_collection_id |
ftciteseerx |
language |
English |
topic |
bhp ehpnetl |
spellingShingle |
bhp ehpnetl Tric Dewailly Gert Mulvad Henning S. Pedersen Pierre Ayotte Jens C. Hansen Articles Concentration of Organochlorines in Human Brain, Liver, and Adipose Tissue Autopsy Samples from Greenland |
topic_facet |
bhp ehpnetl |
description |
Organochlorines are persistent lipophilic compounds that accumulate in Inuit people living in circumpolar countries. Organochlorines accumulate as a result of the Inuits ' large consumption of sea mammal fat; however, available data are limited to blood lipids, milk fat,.and adipose tissue. We report results of organodorine determination in liver, brain, omental fat, and subcutaneous abdominal fat samples collected from deceased Greenlanders between 1992 and 1994. Eleven chlorinated pesticides and 14 polychlorinated biphenyl congeners were measured in tissue lipid extracts by high-resolution gas chromatography with electron capture detection. Mean concentrations of polychlorinated biphenyls, 2,2'-bis(4-chlorophenyl)-1,1-dichllcroethylene,,B-hexachlorocyloherane, heachlorobenzene, mires, transnonachlor, and oxychlordane in adipose tissue samples from Greenlanders were 3-34-fold higher than those measured using the same analytical method in samples from Canadians in Quebec City, Quebec. Brain lipids contained lower concentrations of all organochlorines than lipids etracted from other tissues. Organochiorine residue lewls in lipid extracts from liver, omental fat, and subcutaneous abdominal fat samples were similar, with the exception of i-hexachlorocydohexane, which reached a greater concentration in liver lipids than in lipids from both adipose tissues (4-fold; p < 0.05). Comparisons with available international data on adipose tissue levels reveal that the organochlorine body burden in the Inuit population of Greenland is presently among the highest resulting from environmental exposure. |
author2 |
The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Tric Dewailly Gert Mulvad Henning S. Pedersen Pierre Ayotte Jens C. Hansen |
author_facet |
Tric Dewailly Gert Mulvad Henning S. Pedersen Pierre Ayotte Jens C. Hansen |
author_sort |
Tric Dewailly |
title |
Articles Concentration of Organochlorines in Human Brain, Liver, and Adipose Tissue Autopsy Samples from Greenland |
title_short |
Articles Concentration of Organochlorines in Human Brain, Liver, and Adipose Tissue Autopsy Samples from Greenland |
title_full |
Articles Concentration of Organochlorines in Human Brain, Liver, and Adipose Tissue Autopsy Samples from Greenland |
title_fullStr |
Articles Concentration of Organochlorines in Human Brain, Liver, and Adipose Tissue Autopsy Samples from Greenland |
title_full_unstemmed |
Articles Concentration of Organochlorines in Human Brain, Liver, and Adipose Tissue Autopsy Samples from Greenland |
title_sort |
articles concentration of organochlorines in human brain, liver, and adipose tissue autopsy samples from greenland |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.6802 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland greenlander* inuit inuits |
genre_facet |
Greenland greenlander* inuit inuits |
op_source |
ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/b5/36/Environ_Health_Perspect_1999_Oct_107(10)_823-828.tar.gz |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.6802 |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
_version_ |
1766017767739228160 |