Research Systemic Effects of Arctic Pollutants in Beluga Whales Indicated by CYP1A1 Expression
Cytochrome P450 1A1 (CYP1A1) is induced by exposure to polycyclic aromatic hydrocarbons (PAHs) and planar halogenated aromatic hydrocarbons (PHAHs) such as non-ortho polychlorinated biphenyls (PCBs). In this study, we examined CYP1A1 protein expression immunohistochemically in multiple organs of bel...
Main Authors: | , , , , , , , |
---|---|
Other Authors: | |
Format: | Text |
Language: | English |
Subjects: | |
Online Access: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.3289 |
id |
ftciteseerx:oai:CiteSeerX.psu:10.1.1.276.3289 |
---|---|
record_format |
openpolar |
spelling |
ftciteseerx:oai:CiteSeerX.psu:10.1.1.276.3289 2023-05-15T14:36:55+02:00 Research Systemic Effects of Arctic Pollutants in Beluga Whales Indicated by CYP1A1 Expression Joanna Y. Wilson Suzy R. Cooke Michael J. Moore Daniel Martineau Igor Mikaelian Donald A. Metner W. Lyle Lockhart John J. Stegeman The Pennsylvania State University CiteSeerX Archives application/zip http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.3289 en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.3289 Metadata may be used without restrictions as long as the oai identifier remains attached to it. ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/77/47/Environ_Health_Perspect_2005_Nov_14_113(11)_1594-1599.tar.gz Key words Arctic beluga whale CYP1A1 cytochrome P450 1A1 immunohistochemistry St text ftciteseerx 2016-01-07T20:50:27Z Cytochrome P450 1A1 (CYP1A1) is induced by exposure to polycyclic aromatic hydrocarbons (PAHs) and planar halogenated aromatic hydrocarbons (PHAHs) such as non-ortho polychlorinated biphenyls (PCBs). In this study, we examined CYP1A1 protein expression immunohistochemically in multiple organs of beluga whales from two locations in the Arctic and from the St. Lawrence estuary. These beluga populations have some of the lowest (Arctic sites) and highest (St. Lawrence estuary) concentrations of PCBs in blubber of all cetaceans. Samples from these populations might be expected to have different contaminant-induced responses, reflecting their different exposure histories. The pattern and extent of CYP1A1 staining in whales from all three locations were similar to those seen in animal models in which CYP1A has been highly induced, indicating a high-level expression in these whales. CYP1A1 induction has been related to toxic effects of PHAHs or PAHs in some species. In St. Lawrence beluga, the high level of CYP1A1 expression coupled with high levels of contaminants (including CYP1A1 substrates, e.g., PAH procarcinogens potentially activated by CYP1A1) indicates that CYP1A1 could be involved in the development of neoplastic lesions seen in the St. Lawrence beluga population. The systemic high-level expression of CYP1A1 in Arctic beluga suggests that effects of PAHs or PHAHs may be expected in Arctic populations, as well. The high-level expression of CYP1A1 in the Arctic beluga suggests that this species is highly sensitive to CYP1A1 induction by aryl hydrocarbon receptor agonists. Text Arctic Beluga Beluga whale Beluga* Unknown Arctic |
institution |
Open Polar |
collection |
Unknown |
op_collection_id |
ftciteseerx |
language |
English |
topic |
Key words Arctic beluga whale CYP1A1 cytochrome P450 1A1 immunohistochemistry St |
spellingShingle |
Key words Arctic beluga whale CYP1A1 cytochrome P450 1A1 immunohistochemistry St Joanna Y. Wilson Suzy R. Cooke Michael J. Moore Daniel Martineau Igor Mikaelian Donald A. Metner W. Lyle Lockhart John J. Stegeman Research Systemic Effects of Arctic Pollutants in Beluga Whales Indicated by CYP1A1 Expression |
topic_facet |
Key words Arctic beluga whale CYP1A1 cytochrome P450 1A1 immunohistochemistry St |
description |
Cytochrome P450 1A1 (CYP1A1) is induced by exposure to polycyclic aromatic hydrocarbons (PAHs) and planar halogenated aromatic hydrocarbons (PHAHs) such as non-ortho polychlorinated biphenyls (PCBs). In this study, we examined CYP1A1 protein expression immunohistochemically in multiple organs of beluga whales from two locations in the Arctic and from the St. Lawrence estuary. These beluga populations have some of the lowest (Arctic sites) and highest (St. Lawrence estuary) concentrations of PCBs in blubber of all cetaceans. Samples from these populations might be expected to have different contaminant-induced responses, reflecting their different exposure histories. The pattern and extent of CYP1A1 staining in whales from all three locations were similar to those seen in animal models in which CYP1A has been highly induced, indicating a high-level expression in these whales. CYP1A1 induction has been related to toxic effects of PHAHs or PAHs in some species. In St. Lawrence beluga, the high level of CYP1A1 expression coupled with high levels of contaminants (including CYP1A1 substrates, e.g., PAH procarcinogens potentially activated by CYP1A1) indicates that CYP1A1 could be involved in the development of neoplastic lesions seen in the St. Lawrence beluga population. The systemic high-level expression of CYP1A1 in Arctic beluga suggests that effects of PAHs or PHAHs may be expected in Arctic populations, as well. The high-level expression of CYP1A1 in the Arctic beluga suggests that this species is highly sensitive to CYP1A1 induction by aryl hydrocarbon receptor agonists. |
author2 |
The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Joanna Y. Wilson Suzy R. Cooke Michael J. Moore Daniel Martineau Igor Mikaelian Donald A. Metner W. Lyle Lockhart John J. Stegeman |
author_facet |
Joanna Y. Wilson Suzy R. Cooke Michael J. Moore Daniel Martineau Igor Mikaelian Donald A. Metner W. Lyle Lockhart John J. Stegeman |
author_sort |
Joanna Y. Wilson |
title |
Research Systemic Effects of Arctic Pollutants in Beluga Whales Indicated by CYP1A1 Expression |
title_short |
Research Systemic Effects of Arctic Pollutants in Beluga Whales Indicated by CYP1A1 Expression |
title_full |
Research Systemic Effects of Arctic Pollutants in Beluga Whales Indicated by CYP1A1 Expression |
title_fullStr |
Research Systemic Effects of Arctic Pollutants in Beluga Whales Indicated by CYP1A1 Expression |
title_full_unstemmed |
Research Systemic Effects of Arctic Pollutants in Beluga Whales Indicated by CYP1A1 Expression |
title_sort |
research systemic effects of arctic pollutants in beluga whales indicated by cyp1a1 expression |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.3289 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Beluga Beluga whale Beluga* |
genre_facet |
Arctic Beluga Beluga whale Beluga* |
op_source |
ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/77/47/Environ_Health_Perspect_2005_Nov_14_113(11)_1594-1599.tar.gz |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.3289 |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
_version_ |
1766309444072767488 |