Research | Children’s Health Dose–Response Relationship of Prenatal Mercury Exposure and IQ: An Integrative Analysis of Epidemiologic Data
BACKGROUND: Prenatal exposure to mercury has been associated with adverse childhood neurologic outcomes in epidemiologic studies. Dose–response information for this relationship is useful for estimating benefits of reduced mercury exposure. OBJECTIVES: We estimated a dose–response relationship betwe...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.276.1456 2023-05-15T16:10:31+02:00 Research | Children’s Health Dose–Response Relationship of Prenatal Mercury Exposure and IQ: An Integrative Analysis of Epidemiologic Data Daniel A. Axelrad David C. Bellinger Louise M. Ryan Tracey J. Woodruff The Pennsylvania State University CiteSeerX Archives application/zip http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.1456 en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.1456 Metadata may be used without restrictions as long as the oai identifier remains attached to it. ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c4/84/Environ_Health_Perspect_2007_Apr_11_115(4)_609-615.tar.gz text ftciteseerx 2016-01-07T20:49:58Z BACKGROUND: Prenatal exposure to mercury has been associated with adverse childhood neurologic outcomes in epidemiologic studies. Dose–response information for this relationship is useful for estimating benefits of reduced mercury exposure. OBJECTIVES: We estimated a dose–response relationship between maternal mercury body burden and subsequent childhood decrements in intelligence quotient (IQ), using a Bayesian hierarchical model to integrate data from three epidemiologic studies. METHODS: Inputs to the model consist of dose–response coefficients from studies conducted in the Faroe Islands, New Zealand, and the Seychelles Islands. IQ coefficients were available from previous work for the latter two studies, and a coefficient for the Faroe Islands study was estimated from three IQ subtests. Other tests of cognition/achievement were included in the hierarchical model to obtain more accurate estimates of study-to-study and end point–to–end point variability. RESULTS: We find a central estimate of –0.18 IQ points (95 % confidence interval, –0.378 to –0.009) for each parts per million increase of maternal hair mercury, similar to the estimates for both the Faroe Islands and Seychelles studies, and lower in magnitude than the estimate for the New Zealand study. Sensitivity analyses produce similar results, with the IQ coefficient central estimate Text Faroe Islands Unknown Faroe Islands New Zealand |
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BACKGROUND: Prenatal exposure to mercury has been associated with adverse childhood neurologic outcomes in epidemiologic studies. Dose–response information for this relationship is useful for estimating benefits of reduced mercury exposure. OBJECTIVES: We estimated a dose–response relationship between maternal mercury body burden and subsequent childhood decrements in intelligence quotient (IQ), using a Bayesian hierarchical model to integrate data from three epidemiologic studies. METHODS: Inputs to the model consist of dose–response coefficients from studies conducted in the Faroe Islands, New Zealand, and the Seychelles Islands. IQ coefficients were available from previous work for the latter two studies, and a coefficient for the Faroe Islands study was estimated from three IQ subtests. Other tests of cognition/achievement were included in the hierarchical model to obtain more accurate estimates of study-to-study and end point–to–end point variability. RESULTS: We find a central estimate of –0.18 IQ points (95 % confidence interval, –0.378 to –0.009) for each parts per million increase of maternal hair mercury, similar to the estimates for both the Faroe Islands and Seychelles studies, and lower in magnitude than the estimate for the New Zealand study. Sensitivity analyses produce similar results, with the IQ coefficient central estimate |
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The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Daniel A. Axelrad David C. Bellinger Louise M. Ryan Tracey J. Woodruff |
spellingShingle |
Daniel A. Axelrad David C. Bellinger Louise M. Ryan Tracey J. Woodruff Research | Children’s Health Dose–Response Relationship of Prenatal Mercury Exposure and IQ: An Integrative Analysis of Epidemiologic Data |
author_facet |
Daniel A. Axelrad David C. Bellinger Louise M. Ryan Tracey J. Woodruff |
author_sort |
Daniel A. Axelrad |
title |
Research | Children’s Health Dose–Response Relationship of Prenatal Mercury Exposure and IQ: An Integrative Analysis of Epidemiologic Data |
title_short |
Research | Children’s Health Dose–Response Relationship of Prenatal Mercury Exposure and IQ: An Integrative Analysis of Epidemiologic Data |
title_full |
Research | Children’s Health Dose–Response Relationship of Prenatal Mercury Exposure and IQ: An Integrative Analysis of Epidemiologic Data |
title_fullStr |
Research | Children’s Health Dose–Response Relationship of Prenatal Mercury Exposure and IQ: An Integrative Analysis of Epidemiologic Data |
title_full_unstemmed |
Research | Children’s Health Dose–Response Relationship of Prenatal Mercury Exposure and IQ: An Integrative Analysis of Epidemiologic Data |
title_sort |
research | children’s health dose–response relationship of prenatal mercury exposure and iq: an integrative analysis of epidemiologic data |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.1456 |
geographic |
Faroe Islands New Zealand |
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Faroe Islands New Zealand |
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Faroe Islands |
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Faroe Islands |
op_source |
ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c4/84/Environ_Health_Perspect_2007_Apr_11_115(4)_609-615.tar.gz |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.1456 |
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Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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1765995705436995584 |