Mutation and Evolutionary Rates in Adélie Penguins from the Antarctic
Precise estimations of molecular rates are fundamental to our understanding of the processes of evolution. In principle, mutation and evolutionary rates for neutral regions of the same species are expected to be equal. However, a number of recent studies have shown that mutation rates estimated from...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.275.2699 2023-05-15T13:40:59+02:00 Mutation and Evolutionary Rates in Adélie Penguins from the Antarctic Craig D. Millar Andrew Dodd Jennifer Anderson Gillian C. Gibb Peter A. Ritchie ¤a Carlo Baroni Michael D. Woodhams Michael D. Hendy David M. Lambert ¤b The Pennsylvania State University CiteSeerX Archives application/zip http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.275.2699 en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.275.2699 Metadata may be used without restrictions as long as the oai identifier remains attached to it. ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/2f/76/PLoS_Genet_2008_Oct_3_4(10)_e1000209.tar.gz text ftciteseerx 2016-01-07T20:47:53Z Precise estimations of molecular rates are fundamental to our understanding of the processes of evolution. In principle, mutation and evolutionary rates for neutral regions of the same species are expected to be equal. However, a number of recent studies have shown that mutation rates estimated from pedigree material are much faster than evolutionary rates measured over longer time periods. To resolve this apparent contradiction, we have examined the hypervariable region (HVR I) of the mitochondrial genome using families of Adélie penguins (Pygoscelis adeliae) from the Antarctic. We sequenced 344 bps of the HVR I from penguins comprising 508 families with 915 chicks, together with both their parents. All of the 62 germline heteroplasmies that we detected in mothers were also detected in their offspring, consistent with maternal inheritance. These data give an estimated mutation rate (m) of 0.55 mutations/site/Myrs (HPD 95 % confidence interval of 0.29–0.88 mutations/site/Myrs) after accounting for the persistence of these heteroplasmies and the sensitivity of current detection methods. In comparison, the rate of evolution (k) of the same HVR I region, determined using DNA sequences from 162 known age sub-fossil bones spanning a 37,000-year period, was 0.86 substitutions/site/Myrs (HPD 95 % confidence interval of 0.53 and 1.17). Importantly, the latter rate is not statistically different from our estimate of the mutation rate. Text Antarc* Antarctic Pygoscelis adeliae Unknown Antarctic The Antarctic |
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English |
description |
Precise estimations of molecular rates are fundamental to our understanding of the processes of evolution. In principle, mutation and evolutionary rates for neutral regions of the same species are expected to be equal. However, a number of recent studies have shown that mutation rates estimated from pedigree material are much faster than evolutionary rates measured over longer time periods. To resolve this apparent contradiction, we have examined the hypervariable region (HVR I) of the mitochondrial genome using families of Adélie penguins (Pygoscelis adeliae) from the Antarctic. We sequenced 344 bps of the HVR I from penguins comprising 508 families with 915 chicks, together with both their parents. All of the 62 germline heteroplasmies that we detected in mothers were also detected in their offspring, consistent with maternal inheritance. These data give an estimated mutation rate (m) of 0.55 mutations/site/Myrs (HPD 95 % confidence interval of 0.29–0.88 mutations/site/Myrs) after accounting for the persistence of these heteroplasmies and the sensitivity of current detection methods. In comparison, the rate of evolution (k) of the same HVR I region, determined using DNA sequences from 162 known age sub-fossil bones spanning a 37,000-year period, was 0.86 substitutions/site/Myrs (HPD 95 % confidence interval of 0.53 and 1.17). Importantly, the latter rate is not statistically different from our estimate of the mutation rate. |
author2 |
The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Craig D. Millar Andrew Dodd Jennifer Anderson Gillian C. Gibb Peter A. Ritchie ¤a Carlo Baroni Michael D. Woodhams Michael D. Hendy David M. Lambert ¤b |
spellingShingle |
Craig D. Millar Andrew Dodd Jennifer Anderson Gillian C. Gibb Peter A. Ritchie ¤a Carlo Baroni Michael D. Woodhams Michael D. Hendy David M. Lambert ¤b Mutation and Evolutionary Rates in Adélie Penguins from the Antarctic |
author_facet |
Craig D. Millar Andrew Dodd Jennifer Anderson Gillian C. Gibb Peter A. Ritchie ¤a Carlo Baroni Michael D. Woodhams Michael D. Hendy David M. Lambert ¤b |
author_sort |
Craig D. Millar |
title |
Mutation and Evolutionary Rates in Adélie Penguins from the Antarctic |
title_short |
Mutation and Evolutionary Rates in Adélie Penguins from the Antarctic |
title_full |
Mutation and Evolutionary Rates in Adélie Penguins from the Antarctic |
title_fullStr |
Mutation and Evolutionary Rates in Adélie Penguins from the Antarctic |
title_full_unstemmed |
Mutation and Evolutionary Rates in Adélie Penguins from the Antarctic |
title_sort |
mutation and evolutionary rates in adélie penguins from the antarctic |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.275.2699 |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic Pygoscelis adeliae |
genre_facet |
Antarc* Antarctic Pygoscelis adeliae |
op_source |
ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/2f/76/PLoS_Genet_2008_Oct_3_4(10)_e1000209.tar.gz |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.275.2699 |
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Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
_version_ |
1766144077087113216 |