Printed in the United States of America FACTORS RELATING TO COAGULATION, FIBRINOLYSIS AND HEPATIC DAMAGE AFTER LIVER RESECTION

• Main Authors: Atsushi Oguro, Hiroki Taniguchi, Takeshi Daidoh, Akiyoshi Itoh, Nobuhiro Tsukuda, Toshio Takahashi
• Other Authors: The Pennsylvania State University CiteSeerX Archives
• Format: Text
• Language: English
• Published: 1992
• Subjects: DML
• Online Access: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.274.9752

A survey of the blood of twenty-two patients who had undergone hepatic resection was performed. Serum levels of a-2 plasmin inhibitor-plasmin complex initially decreased from 1.58 + 0.31/g/ml on the preoperative day (PREOP), to 0.92 _+ 0.14/dml on the first postoperative day (POD 1), and then increased to 3.13 + 0.92 /g/ml on the seventh postoperative day (POD 7) (mean + SE)). Thrombin-anti-thrombin III complex (14.2 + 4.3 ng/ml on PREOP and 26.0 + 4.1 ng/ml on POD 7 (mean + SE)) and D-dimer (335 + 96 ng/ml on PREOP and 1859 + 258 ng/ml on POD 7 (mean + SE)) increased in the early postoperative stage. The level of 6-keto-prostaglandin Fla increased after the operations (from 13.2 _+ 1.8 pg/ml on PREOP to 37.8 + 12.8 pg/ml on POD 7 (mean + SE)). The level of thromboxane B-2 decreased at first, and then gradually increased and returned to its preoperative level on POD 7 (144.7 + 43.8 pg/ml on PREOP, 57.6 + 27.5 pg/ml on POD and 152.5 + 58.4 pg/ml on POD 7 (mean + SE)). Superoxide dismutase activity increased at first, and then gradually decreased, postoperatively (2.8 + 0.5 NU/ml on PREOP, 4.8 _+ 0.8 NU/ml on POD and 2.6 + 0.3 NU/ml on POD 7 (mean + SE)). That is, biodefensive reactions which protect patients against the shift to disseminated intravascular coagulation (DIC) were inferred with by the increase in antiplatelet aggregation, despite the activation of coagulation and fibrinolytic mechanisms after hepatic resection. KEY WORDS: Coagulation, fibrinolysis, disseminated intravascular coagulation, liver resection, platelet aggregation