R EPORTS Effects of Purifying and Adaptive Selection on Regional Variation
A phylogenetic analysis of 1125 global human mitochondrial DNA (mtDNA) sequences permitted positioning of all nucleotide substitutions according to their order of occurrence. The relative frequency and amino acid conservation of internal branch replacement mutations was found to increase from tropic...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.186.5936 2023-05-15T15:01:32+02:00 R EPORTS Effects of Purifying and Adaptive Selection on Regional Variation In Human Mtdna Eduardo Ruiz-pesini Dan Mishmar Martin Br Vincent Procaccio Douglas C. Wallace The Pennsylvania State University CiteSeerX Archives application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.186.5936 http://www.bec.ucla.edu/papers/Wallace_23.5.05_1.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.186.5936 http://www.bec.ucla.edu/papers/Wallace_23.5.05_1.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://www.bec.ucla.edu/papers/Wallace_23.5.05_1.pdf text ftciteseerx 2016-01-07T16:41:26Z A phylogenetic analysis of 1125 global human mitochondrial DNA (mtDNA) sequences permitted positioning of all nucleotide substitutions according to their order of occurrence. The relative frequency and amino acid conservation of internal branch replacement mutations was found to increase from tropical Africa to temperate Europe and arctic northeastern Siberia. Particularly highly conserved amino acid substitutions were found at the roots of multiple mtDNA lineages from higher latitudes. These same lineages correlate with increased propensity for energy deficiency diseases as well as longevity. Thus, specific mtDNA replacement mutations permitted our ancestors to adapt to more northern climates, and these same variants are influencing our health today. The human mtDNA exhibits dramatic, region-specific sequence variation in indigenous populations (1) (fig. S1). Although previously this was attributed to genetic drift (2) Text Arctic Siberia Unknown Arctic |
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English |
description |
A phylogenetic analysis of 1125 global human mitochondrial DNA (mtDNA) sequences permitted positioning of all nucleotide substitutions according to their order of occurrence. The relative frequency and amino acid conservation of internal branch replacement mutations was found to increase from tropical Africa to temperate Europe and arctic northeastern Siberia. Particularly highly conserved amino acid substitutions were found at the roots of multiple mtDNA lineages from higher latitudes. These same lineages correlate with increased propensity for energy deficiency diseases as well as longevity. Thus, specific mtDNA replacement mutations permitted our ancestors to adapt to more northern climates, and these same variants are influencing our health today. The human mtDNA exhibits dramatic, region-specific sequence variation in indigenous populations (1) (fig. S1). Although previously this was attributed to genetic drift (2) |
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The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
In Human Mtdna Eduardo Ruiz-pesini Dan Mishmar Martin Br Vincent Procaccio Douglas C. Wallace |
spellingShingle |
In Human Mtdna Eduardo Ruiz-pesini Dan Mishmar Martin Br Vincent Procaccio Douglas C. Wallace R EPORTS Effects of Purifying and Adaptive Selection on Regional Variation |
author_facet |
In Human Mtdna Eduardo Ruiz-pesini Dan Mishmar Martin Br Vincent Procaccio Douglas C. Wallace |
author_sort |
In Human Mtdna |
title |
R EPORTS Effects of Purifying and Adaptive Selection on Regional Variation |
title_short |
R EPORTS Effects of Purifying and Adaptive Selection on Regional Variation |
title_full |
R EPORTS Effects of Purifying and Adaptive Selection on Regional Variation |
title_fullStr |
R EPORTS Effects of Purifying and Adaptive Selection on Regional Variation |
title_full_unstemmed |
R EPORTS Effects of Purifying and Adaptive Selection on Regional Variation |
title_sort |
r eports effects of purifying and adaptive selection on regional variation |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.186.5936 http://www.bec.ucla.edu/papers/Wallace_23.5.05_1.pdf |
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Arctic |
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Arctic |
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Arctic Siberia |
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Arctic Siberia |
op_source |
http://www.bec.ucla.edu/papers/Wallace_23.5.05_1.pdf |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.186.5936 http://www.bec.ucla.edu/papers/Wallace_23.5.05_1.pdf |
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Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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1766333549115342848 |