PAH-and PCB-induced alterations of protein tyrosine kinase and cytokine gene transcription in harbor seal (Phoca vitulina) PBMC

• Main Authors: Jennifer C C Neale, Thomas P Kenny, Ronald S Tjeerdema, & M Eric Gershwin
• Other Authors: The Pennsylvania State University CiteSeerX Archives
• Format: Text
• Language: English
• Subjects: Fyn; harbor seal; Phoca vitulina
• Online Access: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1082.7081; http://downloads.hindawi.com/journals/jir/2005/786243.pdf

Abstract Mechanisms underlying in vitro immunomodulatory effects of polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) were investigated in harbor seal peripheral leukocytes, via real-time PCR. We examined the relative genetic expression of the protein tyrosine kinases (PTK...