200468.march
ABSTRACT. Objective. The marked regional variation in the incidence, prevalence, and presentation of systemic lupus erythematosus (SLE) is possibly related to differing spectra of local environmental factors. The aim of this study was to describe such features in a homogenous Caucasian population ex...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.1081.7655 2023-05-15T15:10:08+02:00 200468.march Hans C Nossent Heather The Pennsylvania State University CiteSeerX Archives application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1081.7655 http://www.jrheum.org/content/jrheum/28/3/539.full.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1081.7655 http://www.jrheum.org/content/jrheum/28/3/539.full.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://www.jrheum.org/content/jrheum/28/3/539.full.pdf text ftciteseerx 2020-05-03T00:25:50Z ABSTRACT. Objective. The marked regional variation in the incidence, prevalence, and presentation of systemic lupus erythematosus (SLE) is possibly related to differing spectra of local environmental factors. The aim of this study was to describe such features in a homogenous Caucasian population exposed to an Arctic climate. Methods. The study area consisted of the 2 northernmost counties of Norway (middle population 222,403) where 4 hospitals (containing only one rheumatology service) provide specialized health care. Retrieval sources were (1) hospital inpatient discharge registries; (2) hospital outpatient registries; (3) mortality database of the National Office for Statistics. Databases were searched with codes for SLE, Sjögren's syndrome, unclassified connective tissue disease, and discoid lupus for the period 1978-96. Only patients meeting 1982 American College of Rheumatology criteria for SLE were included in the analysis. Annual incidence rate (AIR), point prevalence (PP), and mortality rates were estimated per 100,000 at risk. Results. Eighty-three incident cases of adult SLE (87% female, mean age 40.6 yrs at diagnosis) were encountered. Crude AIR of SLE in the whole study period was 2.6 (95% CI 1.9-2.9) for adults. Sexspecific AIR was 4.6 for adult women and 0.6 for adult men. AIR in the first (2.4) and second 9-year period (2.7) was similar (p > 0.2). The crude overall PP for SLE at January 1, 1996, was 44.9 and was highest in women aged 31-49 (PP 102.5). Mortality in incident cases was 9.6% (after a mean followup of 99 mo) with overall 10-year survival estimated at 75%. Text Arctic Unknown Arctic Norway |
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ABSTRACT. Objective. The marked regional variation in the incidence, prevalence, and presentation of systemic lupus erythematosus (SLE) is possibly related to differing spectra of local environmental factors. The aim of this study was to describe such features in a homogenous Caucasian population exposed to an Arctic climate. Methods. The study area consisted of the 2 northernmost counties of Norway (middle population 222,403) where 4 hospitals (containing only one rheumatology service) provide specialized health care. Retrieval sources were (1) hospital inpatient discharge registries; (2) hospital outpatient registries; (3) mortality database of the National Office for Statistics. Databases were searched with codes for SLE, Sjögren's syndrome, unclassified connective tissue disease, and discoid lupus for the period 1978-96. Only patients meeting 1982 American College of Rheumatology criteria for SLE were included in the analysis. Annual incidence rate (AIR), point prevalence (PP), and mortality rates were estimated per 100,000 at risk. Results. Eighty-three incident cases of adult SLE (87% female, mean age 40.6 yrs at diagnosis) were encountered. Crude AIR of SLE in the whole study period was 2.6 (95% CI 1.9-2.9) for adults. Sexspecific AIR was 4.6 for adult women and 0.6 for adult men. AIR in the first (2.4) and second 9-year period (2.7) was similar (p > 0.2). The crude overall PP for SLE at January 1, 1996, was 44.9 and was highest in women aged 31-49 (PP 102.5). Mortality in incident cases was 9.6% (after a mean followup of 99 mo) with overall 10-year survival estimated at 75%. |
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The Pennsylvania State University CiteSeerX Archives |
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Hans C Nossent Heather |
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Hans C Nossent Heather 200468.march |
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Hans C Nossent Heather |
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Hans C Nossent |
title |
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http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1081.7655 http://www.jrheum.org/content/jrheum/28/3/539.full.pdf |
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Arctic Norway |
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Arctic Norway |
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Arctic |
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http://www.jrheum.org/content/jrheum/28/3/539.full.pdf |
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http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1081.7655 http://www.jrheum.org/content/jrheum/28/3/539.full.pdf |
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Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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