A Review of Tumour Initiating Cells in Veterinary Oncology and Potential Implications in Canine Transmissible Venereal Tumours. *For Correspondence

• Main Authors: Fabrizio Grandi, Helio Amante Miot, Bruno Cogliati, Noeme Sousa Rocha
• Other Authors: The Pennsylvania State University CiteSeerX Archives
• Format: Text
• Language: English
• Subjects: Murchison; Antarc*; Antarctica
• Online Access: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1078.8717; http://www.rroij.com/open-access/a-review-of-tumour-initiating-cells-in-veterinary-oncology-andpotential-implications-in-canine-transmissible-venereal-tumours-.pdf

ABSTRACT The canine transmissible venereal tumour (CTVT) is a transplantable neoplasia considered an allograft. However, information about the origin and carcinogenesis process is scarcely known. Currently, some neoplasms are believed to arise from tumour-initiating cells (TIC's) classically described in human myeloid leukemia. TVT intrinsic characteristics provide evidence of a possible TIC's participation in carcinogenesis process of this malignancy. In this review, we highlight CTVT as a cancer stem cell model and describe the four main TIC markers commonly used to enrich tumour initiating cells in canine and human tumours. CANINE VENEREAL TRANSMISSIBLE TUMOUR (CTVT) The CTVT, one of the oldest somatic tumours, has been widely inquired to determine source, mode of transmission, and factors associated to spontaneous regression Initially described in London, 1810 Nowadays, the origin of TVT is estimated thousands of years ago in ancestral old wolves of East Asia. Along the natural history of the disease, genetic instability would have generated cumulative character of mutations, followed by genetic stabilization after subsequent passages CTVT has been detected in most continents, except Antarctica. It is commonly reported in tropical and subtropical regions, 14 RRJVS| Volume 2 | Issue 2 | March, 2016 including the southern region of the United States, Central and South America, Southeast Europe, Ireland, China, Middle East, Africa, Bahamas, Japan, India and Brazil Strakova and Murchison Likewise, through a historical analysis in London and Thailand, Strakova and Murchison In Brazil, a regional epidemiological study conducted in the Municipality of Botucatu, from 1994 to 2003, showed a CTVT prevalence of 17.1 % in 5798 cytopathology examinations in dogs, all performed by the Cytology Department, Faculty of Veterinary Medicine and Animal Science, UNESP, Campus Botucatu. The annual incidence ranged from 11.8 % to 24.1 % during the same period Data relating to breed predisposition, sex or age are contradictory, ...