Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress
This study focused on the protective actions of Empetrum nigrum against ultraviolet B (UVB) radiation in human HaCaT keratinocytes. An ethyl acetate extract of E. nigrum (ENE) increased cell viability decreased by exposure to UVB rays. ENE also absorbed UVB radiation and scavenged UVB-induced intrac...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.1075.3333 2023-05-15T16:06:05+02:00 Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress Ki Cheon Kim Daeshin Kim Sang Cheol Kim Eunsun Jung Deokhoon Park Jin Won Hyun Guillermo Schmeda-Hirschmann The Pennsylvania State University CiteSeerX Archives application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1075.3333 http://downloads.hindawi.com/journals/ecam/2013/983609.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1075.3333 http://downloads.hindawi.com/journals/ecam/2013/983609.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://downloads.hindawi.com/journals/ecam/2013/983609.pdf text ftciteseerx 2020-04-26T00:29:13Z This study focused on the protective actions of Empetrum nigrum against ultraviolet B (UVB) radiation in human HaCaT keratinocytes. An ethyl acetate extract of E. nigrum (ENE) increased cell viability decreased by exposure to UVB rays. ENE also absorbed UVB radiation and scavenged UVB-induced intracellular reactive oxygen species (ROS) in HaCaT keratinocytes. In addition, ENE shielded HaCaT keratinocytes from damage to cellular components (e.g., peroxidation of lipids, modification of proteins, and breakage of DNA strands) following UVB irradiation. Furthermore, ENE protected against UVB-induced apoptotic cell death, as determined by a reduction in the numbers of apoptotic bodies and sub-G 1 hypodiploid cells, as well as by the recovery of mitochondrial membrane potential. The results of the current study therefore suggest that ENE safeguards human keratinocytes against UVB-induced cellular damage via the absorption of UVB ray and scavenging of UVB-generated ROS. Text Empetrum nigrum Unknown |
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description |
This study focused on the protective actions of Empetrum nigrum against ultraviolet B (UVB) radiation in human HaCaT keratinocytes. An ethyl acetate extract of E. nigrum (ENE) increased cell viability decreased by exposure to UVB rays. ENE also absorbed UVB radiation and scavenged UVB-induced intracellular reactive oxygen species (ROS) in HaCaT keratinocytes. In addition, ENE shielded HaCaT keratinocytes from damage to cellular components (e.g., peroxidation of lipids, modification of proteins, and breakage of DNA strands) following UVB irradiation. Furthermore, ENE protected against UVB-induced apoptotic cell death, as determined by a reduction in the numbers of apoptotic bodies and sub-G 1 hypodiploid cells, as well as by the recovery of mitochondrial membrane potential. The results of the current study therefore suggest that ENE safeguards human keratinocytes against UVB-induced cellular damage via the absorption of UVB ray and scavenging of UVB-generated ROS. |
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The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Ki Cheon Kim Daeshin Kim Sang Cheol Kim Eunsun Jung Deokhoon Park Jin Won Hyun Guillermo Schmeda-Hirschmann |
spellingShingle |
Ki Cheon Kim Daeshin Kim Sang Cheol Kim Eunsun Jung Deokhoon Park Jin Won Hyun Guillermo Schmeda-Hirschmann Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress |
author_facet |
Ki Cheon Kim Daeshin Kim Sang Cheol Kim Eunsun Jung Deokhoon Park Jin Won Hyun Guillermo Schmeda-Hirschmann |
author_sort |
Ki Cheon Kim |
title |
Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress |
title_short |
Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress |
title_full |
Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress |
title_fullStr |
Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress |
title_full_unstemmed |
Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress |
title_sort |
ultraviolet b-induced cell damage via absorption of radiation and inhibition of oxidative stress |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1075.3333 http://downloads.hindawi.com/journals/ecam/2013/983609.pdf |
genre |
Empetrum nigrum |
genre_facet |
Empetrum nigrum |
op_source |
http://downloads.hindawi.com/journals/ecam/2013/983609.pdf |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1075.3333 http://downloads.hindawi.com/journals/ecam/2013/983609.pdf |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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1766401992639381504 |