HYPOGLYCEMIC EFFECTS OF AQUEOUS AND ETHANOLIC EXTRACTS OF DANDELION (TARAXACUM OFFICINALE F.H. WIGG.) LEAVES AND ROOTS ON STREPTOZOTOCIN-INDUCED ALBINO RATS

• Main Authors: Chinaka Nnamdi, Uwakwe A A 2, Chuku L C
• Other Authors: The Pennsylvania State University CiteSeerX Archives
• Format: Text
• Language: English
• Subjects: Rattus rattus
• Online Access: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1072.436; http://gjrmi.com/Upload/Issue6/Chinaka%20Nnmadi%20et%20al.,GJRMI%201%286%29%20211-217.pdf

ABSTRACT The effects of aqueous and ethanolic extracts of Taraxacum officinale F.H. Wigg. leaves and roots on fasting blood glucose (FBG) levels of normal and streptozotocin-induced diabetic Wistar albino rats (Rattus rattus) were studied. Exactly 75 Wistar albino rats weighing between 100-225 g were used for the study, and a total of four groups were created. Two groups were divided into six sub-groups of five rats each for the leaf and root extracts respectively, with the remaining two groups being the normal control rats (NCR) and diabetic control rats (DCR). The two sub-groups were thus; sub I, comprising of sub-groups 1-4 which were for diabetic test rats (DTR) on 6% and 10% of aqueous and ethanolic extracts of leaves respectively, while sub-group 5 and 6 were normal test rats (NTR) on 10% of both extracts of leaves respectively. Same was applicable for sub II which represents the roots extracts. After STZ-induction, the course of hyperglycemia was monitored by estimation of FBG. Then administration of T. officinale leaf and root extracts (Aq. and Et.) commenced and lasted for 21 days. Changes in FBG concentration between the NCR and DCR against NTR and DTR treated with two doses (300 mg/kg and 500 mg/kg bodyweight twice a day) of the extracts were evaluated using one way Analysis of Variance (ANOVA). When compared, the FBG levels of the DCR and DTR varied significantly (P < 0.05). Whereas the mean conc. of FBG levels of NCR was (4.4 ± 0.12 mmol/l) that of DCR was (27.1 ± 1.59 mmol/l). On administration of 6% and 10% concentration of the extracts to the DTR and NTR, statistically significant decrease (P ≤ 0.05) in glucose concentration was observed. The FBG level of DTR on 6% leaf extract dropped from 17.1 ± 0.18-9.3 ± 1.86 mmol/l, those on 10% dropped from 18.3 ± 2.58-9.9 ± 1.00 mmol/l. The NTR on 10% leaf extract dropped from 9.9 ± 0.76-7.9 ± 1.00 mmol/l. For the root extract, FBG levels of DTR on 6% and 10% extracts dropped from 15.8 ± 0.18-9.6 ± 2.10 mmol/l and 16.0 ± 0.71-7.5 ± 1.46 mmol/l ...