Protective effect of some antioxidants on the brain of adult male albino rats, Rattus rattus, exposed to heavy metals

Adult male albino rats were exposed to 100 mg/L of lead acetate or 100 mg/L sodium arsenate in drinking water for 3 and 6 weeks, lead and arsenic inhibit cholinesterase activity after both time intervals, with percentage reached 23% and 25% in lead and arsenic after 6 weeks, respectively. The result...

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Main Authors: E A Amal, H M Mona
Other Authors: The Pennsylvania State University CiteSeerX Archives
Format: Text
Language:English
Published: 2009
Subjects:
Online Access:http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1053.2318
http://www.isisn.org/BR%206%281%29%202009/12-19%206%281%29%202009%20BR-104.pdf
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spelling ftciteseerx:oai:CiteSeerX.psu:10.1.1.1053.2318 2023-05-15T18:05:25+02:00 Protective effect of some antioxidants on the brain of adult male albino rats, Rattus rattus, exposed to heavy metals E A Amal H M Mona The Pennsylvania State University CiteSeerX Archives 2009 application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1053.2318 http://www.isisn.org/BR%206%281%29%202009/12-19%206%281%29%202009%20BR-104.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1053.2318 http://www.isisn.org/BR%206%281%29%202009/12-19%206%281%29%202009%20BR-104.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://www.isisn.org/BR%206%281%29%202009/12-19%206%281%29%202009%20BR-104.pdf text 2009 ftciteseerx 2020-04-12T00:17:47Z Adult male albino rats were exposed to 100 mg/L of lead acetate or 100 mg/L sodium arsenate in drinking water for 3 and 6 weeks, lead and arsenic inhibit cholinesterase activity after both time intervals, with percentage reached 23% and 25% in lead and arsenic after 6 weeks, respectively. The results revealed that lead or arsenic leading to increase in relative brain weight in most of the experimental period. Using antox, (an antioxidant contains three supplementary nutritional vitamins A, C and E with rare element selenium) with lead or arsenic led to an improvement of serum cholinesterase activity in rats and also relative brain weight. Histological studies showed that lead and arsenic treated rats induced neuron injuries and change in brain cells. Rats treated with antox during administration of lead or arsenic repair some injuries of brain cells and neuron induced by lead or arsenic. Rats treated with both lead or arsenic and antox revealed an improvement in histopathological alteration induced by lead or by arsenic after 3 weeks and 6 weeks. This proved the effectiveness of antox that attributed to its antioxidant properties. In conclusion, heavy metals i.e. lead and arsenic proved severely neurotoxic and antox reduces the resulting damage probably due to its ability to neutralize free radicals that are generated by lead and arsenic. Text Rattus rattus Unknown
institution Open Polar
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description Adult male albino rats were exposed to 100 mg/L of lead acetate or 100 mg/L sodium arsenate in drinking water for 3 and 6 weeks, lead and arsenic inhibit cholinesterase activity after both time intervals, with percentage reached 23% and 25% in lead and arsenic after 6 weeks, respectively. The results revealed that lead or arsenic leading to increase in relative brain weight in most of the experimental period. Using antox, (an antioxidant contains three supplementary nutritional vitamins A, C and E with rare element selenium) with lead or arsenic led to an improvement of serum cholinesterase activity in rats and also relative brain weight. Histological studies showed that lead and arsenic treated rats induced neuron injuries and change in brain cells. Rats treated with antox during administration of lead or arsenic repair some injuries of brain cells and neuron induced by lead or arsenic. Rats treated with both lead or arsenic and antox revealed an improvement in histopathological alteration induced by lead or by arsenic after 3 weeks and 6 weeks. This proved the effectiveness of antox that attributed to its antioxidant properties. In conclusion, heavy metals i.e. lead and arsenic proved severely neurotoxic and antox reduces the resulting damage probably due to its ability to neutralize free radicals that are generated by lead and arsenic.
author2 The Pennsylvania State University CiteSeerX Archives
format Text
author E A Amal
H M Mona
spellingShingle E A Amal
H M Mona
Protective effect of some antioxidants on the brain of adult male albino rats, Rattus rattus, exposed to heavy metals
author_facet E A Amal
H M Mona
author_sort E A Amal
title Protective effect of some antioxidants on the brain of adult male albino rats, Rattus rattus, exposed to heavy metals
title_short Protective effect of some antioxidants on the brain of adult male albino rats, Rattus rattus, exposed to heavy metals
title_full Protective effect of some antioxidants on the brain of adult male albino rats, Rattus rattus, exposed to heavy metals
title_fullStr Protective effect of some antioxidants on the brain of adult male albino rats, Rattus rattus, exposed to heavy metals
title_full_unstemmed Protective effect of some antioxidants on the brain of adult male albino rats, Rattus rattus, exposed to heavy metals
title_sort protective effect of some antioxidants on the brain of adult male albino rats, rattus rattus, exposed to heavy metals
publishDate 2009
url http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1053.2318
http://www.isisn.org/BR%206%281%29%202009/12-19%206%281%29%202009%20BR-104.pdf
genre Rattus rattus
genre_facet Rattus rattus
op_source http://www.isisn.org/BR%206%281%29%202009/12-19%206%281%29%202009%20BR-104.pdf
op_relation http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1053.2318
http://www.isisn.org/BR%206%281%29%202009/12-19%206%281%29%202009%20BR-104.pdf
op_rights Metadata may be used without restrictions as long as the oai identifier remains attached to it.
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