Abstract Background: Hibernation involves periods of severely depressed metabolism (torpor) and decreases in body temperature (Tb). Small arctic mammals (<5kg), in which Tb generally drop drastically, display leukopenia during hibernation. This raised the question of whether the decreased leukocy...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.1050.8458 2023-05-15T15:09:30+02:00 Berolla Sahdo Alina L Evans Jon M Arnemo Ole Fröbert Eva Särndahl Stéphane Blanc The Pennsylvania State University CiteSeerX Archives 2013 application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1050.8458 http://bearproject.info/wp-content/uploads/2014/10/2013-A149-Sahdo-et-al-Bear-body-temperature-and-immune-cells-InternJMedSci.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1050.8458 http://bearproject.info/wp-content/uploads/2014/10/2013-A149-Sahdo-et-al-Bear-body-temperature-and-immune-cells-InternJMedSci.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://bearproject.info/wp-content/uploads/2014/10/2013-A149-Sahdo-et-al-Bear-body-temperature-and-immune-cells-InternJMedSci.pdf text 2013 ftciteseerx 2020-04-05T00:28:55Z Abstract Background: Hibernation involves periods of severely depressed metabolism (torpor) and decreases in body temperature (Tb). Small arctic mammals (<5kg), in which Tb generally drop drastically, display leukopenia during hibernation. This raised the question of whether the decreased leukocyte counts in mammalian hibernators is due to torpor per se or is secondary to low Tb. The present study examined immune cell counts in brown bears (Ursus arctos), where torpor is only associated with shallow decreases in Tb. The results were compared across hibernator species for which immune and Tb data were available. Methods and Results: The white blood cell counts were determined by flow cytometry in 13 bears captured in the field both during summer and winter over 2 years time. Tb dropped from 39.6±0.8 to 33.5±1.1°C during hibernation. Blood neutrophils and monocytes were lower during hibernation than during the active period (47%, p= 0.001; 43%, p=0.039, respectively), whereas no change in lymphocyte counts was detected (p=0.599). Further, combining our data and those from 10 studies on 9 hibernating species suggested that the decline in Tb explained the decrease in innate immune cells (R 2 =0.83, p<0.0001). Conclusions: Bears have fewer innate immune cells in circulation during hibernation, which may represent a suppressed innate immune system. Across species comparison suggests that, both in small and large hibernators, Tb is the main driver of immune function regulation during winter dormancy. The lack of a difference in lymphocyte counts in this context requires further investigations. Text Arctic Ursus arctos Unknown Arctic |
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Abstract Background: Hibernation involves periods of severely depressed metabolism (torpor) and decreases in body temperature (Tb). Small arctic mammals (<5kg), in which Tb generally drop drastically, display leukopenia during hibernation. This raised the question of whether the decreased leukocyte counts in mammalian hibernators is due to torpor per se or is secondary to low Tb. The present study examined immune cell counts in brown bears (Ursus arctos), where torpor is only associated with shallow decreases in Tb. The results were compared across hibernator species for which immune and Tb data were available. Methods and Results: The white blood cell counts were determined by flow cytometry in 13 bears captured in the field both during summer and winter over 2 years time. Tb dropped from 39.6±0.8 to 33.5±1.1°C during hibernation. Blood neutrophils and monocytes were lower during hibernation than during the active period (47%, p= 0.001; 43%, p=0.039, respectively), whereas no change in lymphocyte counts was detected (p=0.599). Further, combining our data and those from 10 studies on 9 hibernating species suggested that the decline in Tb explained the decrease in innate immune cells (R 2 =0.83, p<0.0001). Conclusions: Bears have fewer innate immune cells in circulation during hibernation, which may represent a suppressed innate immune system. Across species comparison suggests that, both in small and large hibernators, Tb is the main driver of immune function regulation during winter dormancy. The lack of a difference in lymphocyte counts in this context requires further investigations. |
author2 |
The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Berolla Sahdo Alina L Evans Jon M Arnemo Ole Fröbert Eva Särndahl Stéphane Blanc |
spellingShingle |
Berolla Sahdo Alina L Evans Jon M Arnemo Ole Fröbert Eva Särndahl Stéphane Blanc |
author_facet |
Berolla Sahdo Alina L Evans Jon M Arnemo Ole Fröbert Eva Särndahl Stéphane Blanc |
author_sort |
Berolla Sahdo |
publishDate |
2013 |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1050.8458 http://bearproject.info/wp-content/uploads/2014/10/2013-A149-Sahdo-et-al-Bear-body-temperature-and-immune-cells-InternJMedSci.pdf |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Ursus arctos |
genre_facet |
Arctic Ursus arctos |
op_source |
http://bearproject.info/wp-content/uploads/2014/10/2013-A149-Sahdo-et-al-Bear-body-temperature-and-immune-cells-InternJMedSci.pdf |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1050.8458 http://bearproject.info/wp-content/uploads/2014/10/2013-A149-Sahdo-et-al-Bear-body-temperature-and-immune-cells-InternJMedSci.pdf |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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1766340683375837184 |