Sulfonation of environmental chemicals and their metabolites in the polar bear (Ursus maritimus). Drug Metab Dispos
ABSTRACT: Although its habitat comprises mostly remote regions of the Arctic, the polar bear is subject to bioaccumulation of persistent environmental pollutants. Along with their phase I metabolites, they are potential substrates for detoxification via sulfonation and glucuronidation. The capabilit...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.1049.9895 2023-05-15T15:02:28+02:00 Sulfonation of environmental chemicals and their metabolites in the polar bear (Ursus maritimus). Drug Metab Dispos James C Sacco Margaret O James The Pennsylvania State University CiteSeerX Archives 2005 application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1049.9895 http://dmd.aspetjournals.org/content/dmd/33/9/1341.full.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1049.9895 http://dmd.aspetjournals.org/content/dmd/33/9/1341.full.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://dmd.aspetjournals.org/content/dmd/33/9/1341.full.pdf text 2005 ftciteseerx 2020-04-05T00:26:07Z ABSTRACT: Although its habitat comprises mostly remote regions of the Arctic, the polar bear is subject to bioaccumulation of persistent environmental pollutants. Along with their phase I metabolites, they are potential substrates for detoxification via sulfonation and glucuronidation. The capability of polar bear liver to sulfonate a structurally diverse group of environmental chemicals, that is, 3-hydroxybenzo Triclosan was the most rapidly sulfated (apparent V max 1008 pmol/ min/mg) of the substrates tested. Since sulfonation of an acyclic tertiary alcoholic group, as in TCPM, has not previously been reported, we also examined TCPM conjugation in humans and catfish, both of which formed TCPM-sulfate. The hexachlorinated polychlorinated biphenylols, TCPM, and PCP were poor substrates for sulfonation, suggesting that this may be one reason why these substances and structurally similar xenobiotics persist in polar bears. Text Arctic Ursus maritimus Unknown Arctic |
institution |
Open Polar |
collection |
Unknown |
op_collection_id |
ftciteseerx |
language |
English |
description |
ABSTRACT: Although its habitat comprises mostly remote regions of the Arctic, the polar bear is subject to bioaccumulation of persistent environmental pollutants. Along with their phase I metabolites, they are potential substrates for detoxification via sulfonation and glucuronidation. The capability of polar bear liver to sulfonate a structurally diverse group of environmental chemicals, that is, 3-hydroxybenzo Triclosan was the most rapidly sulfated (apparent V max 1008 pmol/ min/mg) of the substrates tested. Since sulfonation of an acyclic tertiary alcoholic group, as in TCPM, has not previously been reported, we also examined TCPM conjugation in humans and catfish, both of which formed TCPM-sulfate. The hexachlorinated polychlorinated biphenylols, TCPM, and PCP were poor substrates for sulfonation, suggesting that this may be one reason why these substances and structurally similar xenobiotics persist in polar bears. |
author2 |
The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
James C Sacco Margaret O James |
spellingShingle |
James C Sacco Margaret O James Sulfonation of environmental chemicals and their metabolites in the polar bear (Ursus maritimus). Drug Metab Dispos |
author_facet |
James C Sacco Margaret O James |
author_sort |
James C Sacco |
title |
Sulfonation of environmental chemicals and their metabolites in the polar bear (Ursus maritimus). Drug Metab Dispos |
title_short |
Sulfonation of environmental chemicals and their metabolites in the polar bear (Ursus maritimus). Drug Metab Dispos |
title_full |
Sulfonation of environmental chemicals and their metabolites in the polar bear (Ursus maritimus). Drug Metab Dispos |
title_fullStr |
Sulfonation of environmental chemicals and their metabolites in the polar bear (Ursus maritimus). Drug Metab Dispos |
title_full_unstemmed |
Sulfonation of environmental chemicals and their metabolites in the polar bear (Ursus maritimus). Drug Metab Dispos |
title_sort |
sulfonation of environmental chemicals and their metabolites in the polar bear (ursus maritimus). drug metab dispos |
publishDate |
2005 |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1049.9895 http://dmd.aspetjournals.org/content/dmd/33/9/1341.full.pdf |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Ursus maritimus |
genre_facet |
Arctic Ursus maritimus |
op_source |
http://dmd.aspetjournals.org/content/dmd/33/9/1341.full.pdf |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1049.9895 http://dmd.aspetjournals.org/content/dmd/33/9/1341.full.pdf |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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1766334431963906048 |