Age and sex differences in the distribution and ultrasound morphology of carotid atherosclerosis: the Tromso study
Abstract—Atherosclerosis begins early in life and is the major underlying cause of cardiovascular morbidity and death. Yet, population-based information on age and sex differences in the extent and morphology of atherosclerosis throughout life is scarce. Carotid atherosclerosis can be visualized wit...
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ftciteseerx:oai:CiteSeerX.psu:10.1.1.1031.6507 2023-05-15T18:33:54+02:00 Age and sex differences in the distribution and ultrasound morphology of carotid atherosclerosis: the Tromso study Oddmund Joakimsen Kaare H. Bønaa Eva Stensl Bjarne Koster Jacobsen The Pennsylvania State University CiteSeerX Archives 1999 application/pdf http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1031.6507 http://atvb.ahajournals.org/content/atvbaha/19/12/3007.full.pdf en eng http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1031.6507 http://atvb.ahajournals.org/content/atvbaha/19/12/3007.full.pdf Metadata may be used without restrictions as long as the oai identifier remains attached to it. http://atvb.ahajournals.org/content/atvbaha/19/12/3007.full.pdf text 1999 ftciteseerx 2016-10-30T00:13:38Z Abstract—Atherosclerosis begins early in life and is the major underlying cause of cardiovascular morbidity and death. Yet, population-based information on age and sex differences in the extent and morphology of atherosclerosis throughout life is scarce. Carotid atherosclerosis can be visualized with B-mode ultrasound and is a marker of atherosclerosis elsewhere in the circulation. We assessed both the prevalence and the morphology of carotid atherosclerosis by B-mode ultrasound in 3016 men and 3404 women, 25 to 84 years old, who participated in a population health survey. The participation rate was 88%. Plaque morphology was graded according to whether a plaque was predominantly soft (echolucent) or hard (echogenic). Atherosclerotic plaques were found in 55.4 % of the men and 45.8 % of the women. In men, there was a linear increase with age in the prevalence of carotid atherosclerosis, whereas in women, there was a curvilinear age trend, with an inflection in the prevalence rate of women at '50 years of age. The male predominance in atherosclerosis declined after the age of 50 years, the plaque prevalence being similar in elderly men and women. Men had softer plaques than women; this sex difference in plaque morphology increased significantly (P50.005) with age. The sex difference in the prevalence of atherosclerosis and the female age trend in atherosclerosis show significant changes at the age of '50 years, suggesting an adverse effect of menopause on atherosclerosis. The higher proportion of soft plaques in men compared with women increases with age and may partly account for the prevailing male excess risk of coronary heart disease in the elderly despite a similar prevalence of Text Tromso Tromso Unknown Tromso ENVELOPE(16.546,16.546,68.801,68.801) |
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English |
description |
Abstract—Atherosclerosis begins early in life and is the major underlying cause of cardiovascular morbidity and death. Yet, population-based information on age and sex differences in the extent and morphology of atherosclerosis throughout life is scarce. Carotid atherosclerosis can be visualized with B-mode ultrasound and is a marker of atherosclerosis elsewhere in the circulation. We assessed both the prevalence and the morphology of carotid atherosclerosis by B-mode ultrasound in 3016 men and 3404 women, 25 to 84 years old, who participated in a population health survey. The participation rate was 88%. Plaque morphology was graded according to whether a plaque was predominantly soft (echolucent) or hard (echogenic). Atherosclerotic plaques were found in 55.4 % of the men and 45.8 % of the women. In men, there was a linear increase with age in the prevalence of carotid atherosclerosis, whereas in women, there was a curvilinear age trend, with an inflection in the prevalence rate of women at '50 years of age. The male predominance in atherosclerosis declined after the age of 50 years, the plaque prevalence being similar in elderly men and women. Men had softer plaques than women; this sex difference in plaque morphology increased significantly (P50.005) with age. The sex difference in the prevalence of atherosclerosis and the female age trend in atherosclerosis show significant changes at the age of '50 years, suggesting an adverse effect of menopause on atherosclerosis. The higher proportion of soft plaques in men compared with women increases with age and may partly account for the prevailing male excess risk of coronary heart disease in the elderly despite a similar prevalence of |
author2 |
The Pennsylvania State University CiteSeerX Archives |
format |
Text |
author |
Oddmund Joakimsen Kaare H. Bønaa Eva Stensl Bjarne Koster Jacobsen |
spellingShingle |
Oddmund Joakimsen Kaare H. Bønaa Eva Stensl Bjarne Koster Jacobsen Age and sex differences in the distribution and ultrasound morphology of carotid atherosclerosis: the Tromso study |
author_facet |
Oddmund Joakimsen Kaare H. Bønaa Eva Stensl Bjarne Koster Jacobsen |
author_sort |
Oddmund Joakimsen |
title |
Age and sex differences in the distribution and ultrasound morphology of carotid atherosclerosis: the Tromso study |
title_short |
Age and sex differences in the distribution and ultrasound morphology of carotid atherosclerosis: the Tromso study |
title_full |
Age and sex differences in the distribution and ultrasound morphology of carotid atherosclerosis: the Tromso study |
title_fullStr |
Age and sex differences in the distribution and ultrasound morphology of carotid atherosclerosis: the Tromso study |
title_full_unstemmed |
Age and sex differences in the distribution and ultrasound morphology of carotid atherosclerosis: the Tromso study |
title_sort |
age and sex differences in the distribution and ultrasound morphology of carotid atherosclerosis: the tromso study |
publishDate |
1999 |
url |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1031.6507 http://atvb.ahajournals.org/content/atvbaha/19/12/3007.full.pdf |
long_lat |
ENVELOPE(16.546,16.546,68.801,68.801) |
geographic |
Tromso |
geographic_facet |
Tromso |
genre |
Tromso Tromso |
genre_facet |
Tromso Tromso |
op_source |
http://atvb.ahajournals.org/content/atvbaha/19/12/3007.full.pdf |
op_relation |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1031.6507 http://atvb.ahajournals.org/content/atvbaha/19/12/3007.full.pdf |
op_rights |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
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1766218534808977408 |