The article highlighted in this issue is “A PBPK Modeling- Based Approach to Account for Interactions in the Health Risk Assessment of Chemical Mixtures ” by Sami Haddad, Martin

• Main Authors: Rory B. Conolly, Robert Tardif
• Other Authors: The Pennsylvania State University CiteSeerX Archives
• Format: Text
• Language: English
• Subjects: sami
• Online Access: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1029.3573; http://toxsci.oxfordjournals.org/content/63/1/1.full.pdf

The mixture toxicity problem has long challenged toxicolo-gists and regulators (e.g., Jacobson et al., 1958; Jacobziner, 1962). The main public health concerns with mixtures are (1) that interactions of mixture components may lead to toxicities not seen with individual components and (2) that a mixture may exhibit synergism, i.e., that its potency may be much greater than expected based on knowledge of the components. In these situations the mechanism underlying the toxicity of concern includes one or more interactions of mixture compo-nents. As Haddad and colleagues point out in the featured article, the mechanism that generates the toxic response and is a prime determinant of the putative human health risk thus cannot be examined adequately by only studying the individual components of the mixture. Biologically motivated models, particularly physiologically