European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene.

• Published in: Human Molecular Genetics
• Main Authors: Rafnar, T, Vermeulen, S H, Sulem, P, Thorleifsson, G, Aben, Katja K H, Witjes, J A, Grotenhuis, A J, Verhaegh, G W, Hulsbergen-van de Kaa, C A, Besenbacher, S, Gudbjartsson, D, Stacey, S N, Gudmundsson, J, Johannsdottir, H, Bjarnason, H, Zanon, C, Helgadottir, H, Jonasson, J G, Tryggvadottir, L, Jonsson, E, Geirsson, G, Nikulasson, S, Petursdottir, V, Bishop, D T, Chung-Sak, S, Choudhury, Ananya, Elliott, F, Barrett, J H, Knowles, M A, de Verdier, P J, Ryk, C, Lindblom, A, Rudnai, P, Gurzau, E, Koppova, K, Vineis, P, Polidoro, S, Guarrera, S, Sacerdote, C, Panadero, A, Sanz-Velez, J I, Sanchez, M, Valdivia, G, Garcia-Prats, M D, Hengstler, J G, Selinski, S, Gerullis, H, Ovsiannikov, D, Khezri, A, Aminsharifi, Al, Malekzadeh, M, van den Berg, L H, Ophoff, R A, Veldink, J H, Zeegers, M P, Kellen, E, Fostinelli, J, Andreoli, D, Arici, C, Porru, S, Buntinx, F, Ghaderi, A, Golka, K, Mayordomo, J I, Matullo, G, Kumar, R, Steineck, G, Kiltie, A E, Kong, A, Thorsteinsdottir, U, Stefansson, K, Kiemeney, L A
• Other Authors: deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland.
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2011
• Subjects: Adult; Aged; 80 and over; Chromosomes; Human; Pair 18; Disease Progression; European Continental Ancestry Group; Female; Genetic Loci; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Male; Membrane Transport Proteins; Middle Aged; Polymorphism; Single Nucleotide; Reproducibility of Results; Risk Factors; Urinary Bladder Neoplasms; Young Adult; Kidd; Iceland
• Online Access: http://hdl.handle.net/10541/226175; https://doi.org/10.1093/hmg/ddr303

Three genome-wide association studies in Europe and the USA have reported eight urinary bladder cancer (UBC) susceptibility loci. Using extended case and control series and 1000 Genomes imputations of 5 340 737 single-nucleotide polymorphisms (SNPs), we searched for additional loci in the European G...