Binding Pattern Reconstructions of FGF-FGFR Budding-Inducing Signaling in Reef-Building Corals
Reef-building corals play an important role in marine ecosystems. However, owing to climate change, ocean acidification, and predation by invasive crown-of-thorns starfish, these corals are declining. As marine animals comprise polyps, reproduction by asexual budding is pivotal in scleractinian cora...
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Online Access: | http://ir.nigpas.ac.cn/handle/332004/40365 http://ir.nigpas.ac.cn/handle/332004/40366 https://doi.org/10.3389/fphys.2021.759370 |
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ftchinacscnigpas:oai:ir.nigpas.ac.cn:332004/40366 2023-05-15T17:51:29+02:00 Binding Pattern Reconstructions of FGF-FGFR Budding-Inducing Signaling in Reef-Building Corals Guo, Zhuojun Liao, Xin Chen, J. -Y.(陈均远) He, Chunpeng Lu, Zuhong 2022-01-04 http://ir.nigpas.ac.cn/handle/332004/40365 http://ir.nigpas.ac.cn/handle/332004/40366 https://doi.org/10.3389/fphys.2021.759370 英语 eng FRONTIERS MEDIA SA FRONTIERS IN PHYSIOLOGY http://ir.nigpas.ac.cn/handle/332004/40365 http://ir.nigpas.ac.cn/handle/332004/40366 doi:10.3389/fphys.2021.759370 reef-building coral budding reproduction receptor tyrosine kinase full-length transcriptome FGF-FGFR binding models GROWTH-FACTOR RECEPTOR TYROSINE KINASE BUD DETACHMENT HYDRA ACTIVATION DOMAIN BOUNDARIES SUGGESTS Physiology 期刊论文 2022 ftchinacscnigpas https://doi.org/10.3389/fphys.2021.759370 2022-02-25T01:09:28Z Reef-building corals play an important role in marine ecosystems. However, owing to climate change, ocean acidification, and predation by invasive crown-of-thorns starfish, these corals are declining. As marine animals comprise polyps, reproduction by asexual budding is pivotal in scleractinian coral growth. The fibroblast growth factor (FGF) signaling pathway is essential in coral budding morphogenesis. Here, we sequenced the full-length transcriptomes of four common and frequently dominant reef-building corals and screened out the budding-related FGF and FGFR genes. Thereafter, three-dimensional (3D) models of FGF and FGFR proteins as well as FGF-FGFR binding models were reconstructed. Based on our findings, the FGF8-FGFR3 binding models in Pocillopora damicornis, Montipora capricornis, and Acropora muricata are typical receptor tyrosine kinase-signaling pathways that are similar to the Kringelchen (FGFR) in hydra. However, in P. verrucosa, FGF8 is not the FGFR3 ligand, which is found in other hydrozoan animals, and its FGFR3 must be activated by other tyrosine kinase-type ligands. Overall, this study provides background on the potentially budding propagation signaling pathway activated by the applications of biological agents in reef-building coral culture that could aid in the future restoration of coral reefs. Report Ocean acidification Nanjing Institute of Geology and Palaeontology: NIGPAS OpenIR (Chinese Academy of Sciences) Frontiers in Physiology 12 |
institution |
Open Polar |
collection |
Nanjing Institute of Geology and Palaeontology: NIGPAS OpenIR (Chinese Academy of Sciences) |
op_collection_id |
ftchinacscnigpas |
language |
English |
topic |
reef-building coral budding reproduction receptor tyrosine kinase full-length transcriptome FGF-FGFR binding models GROWTH-FACTOR RECEPTOR TYROSINE KINASE BUD DETACHMENT HYDRA ACTIVATION DOMAIN BOUNDARIES SUGGESTS Physiology |
spellingShingle |
reef-building coral budding reproduction receptor tyrosine kinase full-length transcriptome FGF-FGFR binding models GROWTH-FACTOR RECEPTOR TYROSINE KINASE BUD DETACHMENT HYDRA ACTIVATION DOMAIN BOUNDARIES SUGGESTS Physiology Guo, Zhuojun Liao, Xin Chen, J. -Y.(陈均远) He, Chunpeng Lu, Zuhong Binding Pattern Reconstructions of FGF-FGFR Budding-Inducing Signaling in Reef-Building Corals |
topic_facet |
reef-building coral budding reproduction receptor tyrosine kinase full-length transcriptome FGF-FGFR binding models GROWTH-FACTOR RECEPTOR TYROSINE KINASE BUD DETACHMENT HYDRA ACTIVATION DOMAIN BOUNDARIES SUGGESTS Physiology |
description |
Reef-building corals play an important role in marine ecosystems. However, owing to climate change, ocean acidification, and predation by invasive crown-of-thorns starfish, these corals are declining. As marine animals comprise polyps, reproduction by asexual budding is pivotal in scleractinian coral growth. The fibroblast growth factor (FGF) signaling pathway is essential in coral budding morphogenesis. Here, we sequenced the full-length transcriptomes of four common and frequently dominant reef-building corals and screened out the budding-related FGF and FGFR genes. Thereafter, three-dimensional (3D) models of FGF and FGFR proteins as well as FGF-FGFR binding models were reconstructed. Based on our findings, the FGF8-FGFR3 binding models in Pocillopora damicornis, Montipora capricornis, and Acropora muricata are typical receptor tyrosine kinase-signaling pathways that are similar to the Kringelchen (FGFR) in hydra. However, in P. verrucosa, FGF8 is not the FGFR3 ligand, which is found in other hydrozoan animals, and its FGFR3 must be activated by other tyrosine kinase-type ligands. Overall, this study provides background on the potentially budding propagation signaling pathway activated by the applications of biological agents in reef-building coral culture that could aid in the future restoration of coral reefs. |
format |
Report |
author |
Guo, Zhuojun Liao, Xin Chen, J. -Y.(陈均远) He, Chunpeng Lu, Zuhong |
author_facet |
Guo, Zhuojun Liao, Xin Chen, J. -Y.(陈均远) He, Chunpeng Lu, Zuhong |
author_sort |
Guo, Zhuojun |
title |
Binding Pattern Reconstructions of FGF-FGFR Budding-Inducing Signaling in Reef-Building Corals |
title_short |
Binding Pattern Reconstructions of FGF-FGFR Budding-Inducing Signaling in Reef-Building Corals |
title_full |
Binding Pattern Reconstructions of FGF-FGFR Budding-Inducing Signaling in Reef-Building Corals |
title_fullStr |
Binding Pattern Reconstructions of FGF-FGFR Budding-Inducing Signaling in Reef-Building Corals |
title_full_unstemmed |
Binding Pattern Reconstructions of FGF-FGFR Budding-Inducing Signaling in Reef-Building Corals |
title_sort |
binding pattern reconstructions of fgf-fgfr budding-inducing signaling in reef-building corals |
publisher |
FRONTIERS MEDIA SA |
publishDate |
2022 |
url |
http://ir.nigpas.ac.cn/handle/332004/40365 http://ir.nigpas.ac.cn/handle/332004/40366 https://doi.org/10.3389/fphys.2021.759370 |
genre |
Ocean acidification |
genre_facet |
Ocean acidification |
op_relation |
FRONTIERS IN PHYSIOLOGY http://ir.nigpas.ac.cn/handle/332004/40365 http://ir.nigpas.ac.cn/handle/332004/40366 doi:10.3389/fphys.2021.759370 |
op_doi |
https://doi.org/10.3389/fphys.2021.759370 |
container_title |
Frontiers in Physiology |
container_volume |
12 |
_version_ |
1766158652424585216 |