Massive expansion and functional divergence of innate immune genes in a protostome
The molecules that mediate innate immunity are encoded by relatively few genes and exhibit broad specificity. Detailed annotation of the Pacific oyster (Crassostrea gigas) genome, a protostome invertebrate, reveals large-scale duplication and divergence of multigene families encoding molecules that...
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ftchinacasciocas:oai:ir.qdio.ac.cn:337002/25395 2023-05-15T15:58:40+02:00 Massive expansion and functional divergence of innate immune genes in a protostome Zhang, Linlin Li, Li Guo, Ximing Litman, Gary W. Dishaw, Larry J. Zhang, Guofan 2015-03-03 http://ir.qdio.ac.cn/handle/337002/25395 https://doi.org/10.1038/srep08693 英语 eng SCIENTIFIC REPORTS http://ir.qdio.ac.cn/handle/337002/25395 doi:10.1038/srep08693 Article 期刊论文 2015 ftchinacasciocas https://doi.org/10.1038/srep08693 2022-06-27T05:36:55Z The molecules that mediate innate immunity are encoded by relatively few genes and exhibit broad specificity. Detailed annotation of the Pacific oyster (Crassostrea gigas) genome, a protostome invertebrate, reveals large-scale duplication and divergence of multigene families encoding molecules that effect innate immunity. Transcriptome analyses indicate dynamic and orchestrated specific expression of numerous innate immune genes in response to experimental challenge with pathogens, including bacteria, and a pathogenic virus. Variable expression of individual members of the multigene families encoding these genes also occurs during different types of abiotic stress (environmentally-equivalent conditions of temperature, salinity and desiccation). Multiple families of immune genes are responsive in concert to certain biotic and abiotic challenges. Individual members of expanded families of immune genes are differentially expressed under both biotic challenge and abiotic stress conditions. Members of the same families of innate immune molecules also are transcribed in developmental stage- and tissue-specific manners. An integrated, highly complex innate immune system that exhibits remarkable discriminatory properties and responses to different pathogens as well as environmental stress has arisen through the adaptive recruitment of tandem duplicated genes. The co-adaptive evolution of stress and innate immune responses appears to have an ancient origin in phylogeny. Article in Journal/Newspaper Crassostrea gigas Pacific oyster Institute of Oceanology, Chinese Academy of Sciences: IOCAS-IR Pacific Scientific Reports 5 1 |
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Institute of Oceanology, Chinese Academy of Sciences: IOCAS-IR |
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ftchinacasciocas |
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English |
description |
The molecules that mediate innate immunity are encoded by relatively few genes and exhibit broad specificity. Detailed annotation of the Pacific oyster (Crassostrea gigas) genome, a protostome invertebrate, reveals large-scale duplication and divergence of multigene families encoding molecules that effect innate immunity. Transcriptome analyses indicate dynamic and orchestrated specific expression of numerous innate immune genes in response to experimental challenge with pathogens, including bacteria, and a pathogenic virus. Variable expression of individual members of the multigene families encoding these genes also occurs during different types of abiotic stress (environmentally-equivalent conditions of temperature, salinity and desiccation). Multiple families of immune genes are responsive in concert to certain biotic and abiotic challenges. Individual members of expanded families of immune genes are differentially expressed under both biotic challenge and abiotic stress conditions. Members of the same families of innate immune molecules also are transcribed in developmental stage- and tissue-specific manners. An integrated, highly complex innate immune system that exhibits remarkable discriminatory properties and responses to different pathogens as well as environmental stress has arisen through the adaptive recruitment of tandem duplicated genes. The co-adaptive evolution of stress and innate immune responses appears to have an ancient origin in phylogeny. |
format |
Article in Journal/Newspaper |
author |
Zhang, Linlin Li, Li Guo, Ximing Litman, Gary W. Dishaw, Larry J. Zhang, Guofan |
spellingShingle |
Zhang, Linlin Li, Li Guo, Ximing Litman, Gary W. Dishaw, Larry J. Zhang, Guofan Massive expansion and functional divergence of innate immune genes in a protostome |
author_facet |
Zhang, Linlin Li, Li Guo, Ximing Litman, Gary W. Dishaw, Larry J. Zhang, Guofan |
author_sort |
Zhang, Linlin |
title |
Massive expansion and functional divergence of innate immune genes in a protostome |
title_short |
Massive expansion and functional divergence of innate immune genes in a protostome |
title_full |
Massive expansion and functional divergence of innate immune genes in a protostome |
title_fullStr |
Massive expansion and functional divergence of innate immune genes in a protostome |
title_full_unstemmed |
Massive expansion and functional divergence of innate immune genes in a protostome |
title_sort |
massive expansion and functional divergence of innate immune genes in a protostome |
publishDate |
2015 |
url |
http://ir.qdio.ac.cn/handle/337002/25395 https://doi.org/10.1038/srep08693 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_relation |
SCIENTIFIC REPORTS http://ir.qdio.ac.cn/handle/337002/25395 doi:10.1038/srep08693 |
op_doi |
https://doi.org/10.1038/srep08693 |
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Scientific Reports |
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5 |
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1 |
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1766394430730797056 |