Synergistic modulation of neuroendocrine-inflammation pathway by microRNAs facilitates intertidal adaptation of molluscs
Neuroendocrine-immune system is an evolution-conserved regulatory network in maintaining the homeostasis of animals. While knowledge on the roles of neuroendocrine-immune system in the disease and stress responses of organisms is growing, the ecological roles of neuroendocrine-immune system, especia...
Published in: | Fish & Shellfish Immunology |
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2023
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Online Access: | http://ir.qdio.ac.cn/handle/337002/183887 https://doi.org/10.1016/j.fsi.2023.109165 |
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ftchinacasciocas:oai:ir.qdio.ac.cn:337002/183887 2024-04-28T08:16:44+00:00 Synergistic modulation of neuroendocrine-inflammation pathway by microRNAs facilitates intertidal adaptation of molluscs Chen, Hao Wang, Lin Wang, Lingling Zhang, Huan Wang, Hao Song, Linsheng 2023-11-01 http://ir.qdio.ac.cn/handle/337002/183887 https://doi.org/10.1016/j.fsi.2023.109165 英语 eng ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD FISH & SHELLFISH IMMUNOLOGY http://ir.qdio.ac.cn/handle/337002/183887 doi:10.1016/j.fsi.2023.109165 Inflammation response Calmodulin Nitrite oxide Tumor necrosis factor miRNAs Aerial exposure Fisheries Immunology Marine & Freshwater Biology Veterinary Sciences OYSTER CRASSOSTREA-GIGAS STRESS-RESPONSE INVERTEBRATES DESICCATION EXPRESSION HEMOCYTES TOLERANCE EXPOSURE IMMUNITY GENES 期刊论文 2023 ftchinacasciocas https://doi.org/10.1016/j.fsi.2023.109165 2024-04-08T00:16:49Z Neuroendocrine-immune system is an evolution-conserved regulatory network in maintaining the homeostasis of animals. While knowledge on the roles of neuroendocrine-immune system in the disease and stress responses of organisms is growing, the ecological roles of neuroendocrine-immune system, especially how it shapes the unique lifestyle of organisms remain insufficiently investigated. As an endemic and dominant mollusc in intertidal region, oysters have evolved with a primitive neuroendocrine-immune system and with a sessile lifestyle. Recently, a novel neuroendocrine-immune pathway, Ca2+/calmodulin (CaM)-nitrite oxide synthase (NOS)/nitrite oxide (NO)-tumor necrosis factor (TNF) pathway, is identified in oysters and found altered dynamically during aerial exposure, one common but challenging stresses for intertidal organisms and a decisive factor shaping their habitat. Since the pathway proves fatal in prolonged aerial exposure, we hypothesized that the activation/deactivation of pathway could be strictly modulated in adaptation to the sessile lifestyle of oysters. Here, a synergistic modulation on the Ca2+/CaM-NOS/NO-TNF pathway by four members of miR-92 family and two oyster-specific miRNAs was identified, which further hallmarks the resilience and survival strategy of oysters to aerial exposure. Briefly, these six miRNAs were down-regulating CgCaM24243 post-transcriptionally and deactivating the pathway during the early-stage of stress. However, a robust recession of these miRNAs occurred at the late-stage of stress, resulting in the reactivation of pathway and overwhelming accumulation of cytokines. These results demonstrated a complicated interaction between miRNAs and ancient neuroendocrine-immune system, which facilitates the environmental adaptation of intertidal oysters and provides novel insight on the function and evolution of neuroendocrine-immune system in ecological context. Report Crassostrea gigas Institute of Oceanology, Chinese Academy of Sciences: IOCAS-IR Fish & Shellfish Immunology 142 109165 |
institution |
Open Polar |
collection |
Institute of Oceanology, Chinese Academy of Sciences: IOCAS-IR |
op_collection_id |
ftchinacasciocas |
language |
English |
topic |
Inflammation response Calmodulin Nitrite oxide Tumor necrosis factor miRNAs Aerial exposure Fisheries Immunology Marine & Freshwater Biology Veterinary Sciences OYSTER CRASSOSTREA-GIGAS STRESS-RESPONSE INVERTEBRATES DESICCATION EXPRESSION HEMOCYTES TOLERANCE EXPOSURE IMMUNITY GENES |
spellingShingle |
Inflammation response Calmodulin Nitrite oxide Tumor necrosis factor miRNAs Aerial exposure Fisheries Immunology Marine & Freshwater Biology Veterinary Sciences OYSTER CRASSOSTREA-GIGAS STRESS-RESPONSE INVERTEBRATES DESICCATION EXPRESSION HEMOCYTES TOLERANCE EXPOSURE IMMUNITY GENES Chen, Hao Wang, Lin Wang, Lingling Zhang, Huan Wang, Hao Song, Linsheng Synergistic modulation of neuroendocrine-inflammation pathway by microRNAs facilitates intertidal adaptation of molluscs |
topic_facet |
Inflammation response Calmodulin Nitrite oxide Tumor necrosis factor miRNAs Aerial exposure Fisheries Immunology Marine & Freshwater Biology Veterinary Sciences OYSTER CRASSOSTREA-GIGAS STRESS-RESPONSE INVERTEBRATES DESICCATION EXPRESSION HEMOCYTES TOLERANCE EXPOSURE IMMUNITY GENES |
description |
Neuroendocrine-immune system is an evolution-conserved regulatory network in maintaining the homeostasis of animals. While knowledge on the roles of neuroendocrine-immune system in the disease and stress responses of organisms is growing, the ecological roles of neuroendocrine-immune system, especially how it shapes the unique lifestyle of organisms remain insufficiently investigated. As an endemic and dominant mollusc in intertidal region, oysters have evolved with a primitive neuroendocrine-immune system and with a sessile lifestyle. Recently, a novel neuroendocrine-immune pathway, Ca2+/calmodulin (CaM)-nitrite oxide synthase (NOS)/nitrite oxide (NO)-tumor necrosis factor (TNF) pathway, is identified in oysters and found altered dynamically during aerial exposure, one common but challenging stresses for intertidal organisms and a decisive factor shaping their habitat. Since the pathway proves fatal in prolonged aerial exposure, we hypothesized that the activation/deactivation of pathway could be strictly modulated in adaptation to the sessile lifestyle of oysters. Here, a synergistic modulation on the Ca2+/CaM-NOS/NO-TNF pathway by four members of miR-92 family and two oyster-specific miRNAs was identified, which further hallmarks the resilience and survival strategy of oysters to aerial exposure. Briefly, these six miRNAs were down-regulating CgCaM24243 post-transcriptionally and deactivating the pathway during the early-stage of stress. However, a robust recession of these miRNAs occurred at the late-stage of stress, resulting in the reactivation of pathway and overwhelming accumulation of cytokines. These results demonstrated a complicated interaction between miRNAs and ancient neuroendocrine-immune system, which facilitates the environmental adaptation of intertidal oysters and provides novel insight on the function and evolution of neuroendocrine-immune system in ecological context. |
format |
Report |
author |
Chen, Hao Wang, Lin Wang, Lingling Zhang, Huan Wang, Hao Song, Linsheng |
author_facet |
Chen, Hao Wang, Lin Wang, Lingling Zhang, Huan Wang, Hao Song, Linsheng |
author_sort |
Chen, Hao |
title |
Synergistic modulation of neuroendocrine-inflammation pathway by microRNAs facilitates intertidal adaptation of molluscs |
title_short |
Synergistic modulation of neuroendocrine-inflammation pathway by microRNAs facilitates intertidal adaptation of molluscs |
title_full |
Synergistic modulation of neuroendocrine-inflammation pathway by microRNAs facilitates intertidal adaptation of molluscs |
title_fullStr |
Synergistic modulation of neuroendocrine-inflammation pathway by microRNAs facilitates intertidal adaptation of molluscs |
title_full_unstemmed |
Synergistic modulation of neuroendocrine-inflammation pathway by microRNAs facilitates intertidal adaptation of molluscs |
title_sort |
synergistic modulation of neuroendocrine-inflammation pathway by micrornas facilitates intertidal adaptation of molluscs |
publisher |
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
publishDate |
2023 |
url |
http://ir.qdio.ac.cn/handle/337002/183887 https://doi.org/10.1016/j.fsi.2023.109165 |
genre |
Crassostrea gigas |
genre_facet |
Crassostrea gigas |
op_relation |
FISH & SHELLFISH IMMUNOLOGY http://ir.qdio.ac.cn/handle/337002/183887 doi:10.1016/j.fsi.2023.109165 |
op_doi |
https://doi.org/10.1016/j.fsi.2023.109165 |
container_title |
Fish & Shellfish Immunology |
container_volume |
142 |
container_start_page |
109165 |
_version_ |
1797581729073987584 |