Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas
Apoptosis is considered a crucial part of the host defense system in oysters according to previous reports; however, the exact process by which this occurs remains unclear. Besides, mitochondrial apoptosis is the primary method of apoptosis in vertebrate cells, but has been poorly studied in inverte...
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ftchinacasciocas:oai:ir.qdio.ac.cn:337002/143094 2023-05-15T15:57:53+02:00 Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas Li, Yingxiang Zhang, Linlin Qu, Tao Tang, Xueying Li, Li Zhang, Guofan 2017-07-01 http://ir.qdio.ac.cn/handle/337002/143094 https://doi.org/10.1038/cddis.2017.307 英语 eng CELL DEATH & DISEASE Li, Yingxiang,Zhang, Linlin,Qu, Tao,et al. Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas[J]. CELL DEATH & DISEASE,2017,8. http://ir.qdio.ac.cn/handle/337002/143094 doi:10.1038/cddis.2017.307 Article 期刊论文 2017 ftchinacasciocas https://doi.org/10.1038/cddis.2017.307 2022-06-27T05:38:10Z Apoptosis is considered a crucial part of the host defense system in oysters according to previous reports; however, the exact process by which this occurs remains unclear. Besides, mitochondrial apoptosis is the primary method of apoptosis in vertebrate cells, but has been poorly studied in invertebrates and is quite controversial. In this study, we investigated the molecular mechanism of mitochondrial apoptosis in the Pacific oyster Crassostrea gigas. Notably, we show that most key elements involved in the vertebrate mitochondrial apoptosis pathway - including mitochondrial outer membrane permeabilization, cytochrome c release, and caspase activation - are also present in C. gigas. In contrast, the lack of Bcl-2 homology 3-only subfamily members and apoptotic protease activating factor-1 (APAF-1) protein revealed evolutionary diversity from other phyla. Our results support that mitochondrial apoptosis in animals predates the emergence of vertebrates, but suggest that an unexpectedly diverse mitochondrial apoptosis pathway may exist in invertebrates. In addition, our work provided new clues for an improved understanding of how bivalve acclimate themselves to an inconstant environment. Article in Journal/Newspaper Crassostrea gigas Pacific oyster Institute of Oceanology, Chinese Academy of Sciences: IOCAS-IR Pacific Cell Death & Disease 8 7 e2915 e2915 |
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Institute of Oceanology, Chinese Academy of Sciences: IOCAS-IR |
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ftchinacasciocas |
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English |
description |
Apoptosis is considered a crucial part of the host defense system in oysters according to previous reports; however, the exact process by which this occurs remains unclear. Besides, mitochondrial apoptosis is the primary method of apoptosis in vertebrate cells, but has been poorly studied in invertebrates and is quite controversial. In this study, we investigated the molecular mechanism of mitochondrial apoptosis in the Pacific oyster Crassostrea gigas. Notably, we show that most key elements involved in the vertebrate mitochondrial apoptosis pathway - including mitochondrial outer membrane permeabilization, cytochrome c release, and caspase activation - are also present in C. gigas. In contrast, the lack of Bcl-2 homology 3-only subfamily members and apoptotic protease activating factor-1 (APAF-1) protein revealed evolutionary diversity from other phyla. Our results support that mitochondrial apoptosis in animals predates the emergence of vertebrates, but suggest that an unexpectedly diverse mitochondrial apoptosis pathway may exist in invertebrates. In addition, our work provided new clues for an improved understanding of how bivalve acclimate themselves to an inconstant environment. |
format |
Article in Journal/Newspaper |
author |
Li, Yingxiang Zhang, Linlin Qu, Tao Tang, Xueying Li, Li Zhang, Guofan |
spellingShingle |
Li, Yingxiang Zhang, Linlin Qu, Tao Tang, Xueying Li, Li Zhang, Guofan Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas |
author_facet |
Li, Yingxiang Zhang, Linlin Qu, Tao Tang, Xueying Li, Li Zhang, Guofan |
author_sort |
Li, Yingxiang |
title |
Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas |
title_short |
Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas |
title_full |
Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas |
title_fullStr |
Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas |
title_full_unstemmed |
Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas |
title_sort |
conservation and divergence of mitochondrial apoptosis pathway in the pacific oyster, crassostrea gigas |
publishDate |
2017 |
url |
http://ir.qdio.ac.cn/handle/337002/143094 https://doi.org/10.1038/cddis.2017.307 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_relation |
CELL DEATH & DISEASE Li, Yingxiang,Zhang, Linlin,Qu, Tao,et al. Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas[J]. CELL DEATH & DISEASE,2017,8. http://ir.qdio.ac.cn/handle/337002/143094 doi:10.1038/cddis.2017.307 |
op_doi |
https://doi.org/10.1038/cddis.2017.307 |
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Cell Death & Disease |
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8 |
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7 |
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e2915 |
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e2915 |
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1766393593879068672 |