Involvement of LuxS in Aeromonas salmonicida metabolism, virulence and infection in Atlantic salmon (Salmo salar L)
Quorum sensing is a bacterial density dependent communication system, which regarded to regulate cooperative behaviors of community and mediated by extracellular signal molecules named autoinducers (Al). Among various signals, autoinducer-2 (AI-2) is believed to be the messengers inter species and p...
Published in: | Fish & Shellfish Immunology |
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ftchinacasciocas:oai:ir.qdio.ac.cn:337002/136852 2023-05-15T15:31:35+02:00 Involvement of LuxS in Aeromonas salmonicida metabolism, virulence and infection in Atlantic salmon (Salmo salar L) Meng, Lingjie Du, Yishuai Liu, Pengfei Li, Xian Liu, Ying 2017-05-01 http://ir.qdio.ac.cn/handle/337002/136852 https://doi.org/10.1016/j.fsi.2017.03.009 英语 eng FISH & SHELLFISH IMMUNOLOGY Meng, Lingjie,Du, Yishuai,Liu, Pengfei,et al. Involvement of LuxS in Aeromonas salmonicida metabolism, virulence and infection in Atlantic salmon (Salmo salar L)[J]. FISH & SHELLFISH IMMUNOLOGY,2017,64:260-269. http://ir.qdio.ac.cn/handle/337002/136852 doi:10.1016/j.fsi.2017.03.009 Quorum Sensing Ai-2 Luxs Aeromonas Salmonicida Virulence Surface Property A-layer Innate Immnuity Salmo Solar l Article 期刊论文 2017 ftchinacasciocas https://doi.org/10.1016/j.fsi.2017.03.009 2022-06-27T05:38:04Z Quorum sensing is a bacterial density dependent communication system, which regarded to regulate cooperative behaviors of community and mediated by extracellular signal molecules named autoinducers (Al). Among various signals, autoinducer-2 (AI-2) is believed to be the messengers inter species and produced by LuxS. For Aeromonas salmonicida (A. salmonicida), an opportunistic pathogen to many cold-water teleost, little information has been known about the function of AI-2 and LuxS. Therefore, our aim was to preliminarily clarify the function of LuxS in A. salmonicida. The consequences demonstrated that wild type A. salmonicida exhibited Al-2 activity and luxS defective mutant strain fail to produce Al-2 signals. Furthermore, it was suggested that luxS deficiency could impact bacterial morphology, surface properties and virulence dramatically. Challenge experiment showed a tendency that immune factors expressed earlier when Atlantic salmon was infected with AluxS strain. Overall, we hypothesis that Al-2 quorum sensing could regulate the expression of A-layer protein coding gene vapA, and then influence bacterial survival ability when suffered from attack of the host immune system. Though additional studies are warranted, our study will supply a new thinking to control the damage caused by A. salmonicida. (C) 2017 Elsevier Ltd. All rights reserved. Article in Journal/Newspaper Atlantic salmon Salmo salar Institute of Oceanology, Chinese Academy of Sciences: IOCAS-IR Fish & Shellfish Immunology 64 260 269 |
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Open Polar |
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Institute of Oceanology, Chinese Academy of Sciences: IOCAS-IR |
op_collection_id |
ftchinacasciocas |
language |
English |
topic |
Quorum Sensing Ai-2 Luxs Aeromonas Salmonicida Virulence Surface Property A-layer Innate Immnuity Salmo Solar l |
spellingShingle |
Quorum Sensing Ai-2 Luxs Aeromonas Salmonicida Virulence Surface Property A-layer Innate Immnuity Salmo Solar l Meng, Lingjie Du, Yishuai Liu, Pengfei Li, Xian Liu, Ying Involvement of LuxS in Aeromonas salmonicida metabolism, virulence and infection in Atlantic salmon (Salmo salar L) |
topic_facet |
Quorum Sensing Ai-2 Luxs Aeromonas Salmonicida Virulence Surface Property A-layer Innate Immnuity Salmo Solar l |
description |
Quorum sensing is a bacterial density dependent communication system, which regarded to regulate cooperative behaviors of community and mediated by extracellular signal molecules named autoinducers (Al). Among various signals, autoinducer-2 (AI-2) is believed to be the messengers inter species and produced by LuxS. For Aeromonas salmonicida (A. salmonicida), an opportunistic pathogen to many cold-water teleost, little information has been known about the function of AI-2 and LuxS. Therefore, our aim was to preliminarily clarify the function of LuxS in A. salmonicida. The consequences demonstrated that wild type A. salmonicida exhibited Al-2 activity and luxS defective mutant strain fail to produce Al-2 signals. Furthermore, it was suggested that luxS deficiency could impact bacterial morphology, surface properties and virulence dramatically. Challenge experiment showed a tendency that immune factors expressed earlier when Atlantic salmon was infected with AluxS strain. Overall, we hypothesis that Al-2 quorum sensing could regulate the expression of A-layer protein coding gene vapA, and then influence bacterial survival ability when suffered from attack of the host immune system. Though additional studies are warranted, our study will supply a new thinking to control the damage caused by A. salmonicida. (C) 2017 Elsevier Ltd. All rights reserved. |
format |
Article in Journal/Newspaper |
author |
Meng, Lingjie Du, Yishuai Liu, Pengfei Li, Xian Liu, Ying |
author_facet |
Meng, Lingjie Du, Yishuai Liu, Pengfei Li, Xian Liu, Ying |
author_sort |
Meng, Lingjie |
title |
Involvement of LuxS in Aeromonas salmonicida metabolism, virulence and infection in Atlantic salmon (Salmo salar L) |
title_short |
Involvement of LuxS in Aeromonas salmonicida metabolism, virulence and infection in Atlantic salmon (Salmo salar L) |
title_full |
Involvement of LuxS in Aeromonas salmonicida metabolism, virulence and infection in Atlantic salmon (Salmo salar L) |
title_fullStr |
Involvement of LuxS in Aeromonas salmonicida metabolism, virulence and infection in Atlantic salmon (Salmo salar L) |
title_full_unstemmed |
Involvement of LuxS in Aeromonas salmonicida metabolism, virulence and infection in Atlantic salmon (Salmo salar L) |
title_sort |
involvement of luxs in aeromonas salmonicida metabolism, virulence and infection in atlantic salmon (salmo salar l) |
publishDate |
2017 |
url |
http://ir.qdio.ac.cn/handle/337002/136852 https://doi.org/10.1016/j.fsi.2017.03.009 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
FISH & SHELLFISH IMMUNOLOGY Meng, Lingjie,Du, Yishuai,Liu, Pengfei,et al. Involvement of LuxS in Aeromonas salmonicida metabolism, virulence and infection in Atlantic salmon (Salmo salar L)[J]. FISH & SHELLFISH IMMUNOLOGY,2017,64:260-269. http://ir.qdio.ac.cn/handle/337002/136852 doi:10.1016/j.fsi.2017.03.009 |
op_doi |
https://doi.org/10.1016/j.fsi.2017.03.009 |
container_title |
Fish & Shellfish Immunology |
container_volume |
64 |
container_start_page |
260 |
op_container_end_page |
269 |
_version_ |
1766362102244573184 |