The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas
The neuroendocrine-immune (NEI) regulatory network is a complex system, which plays an indispensable role in the immunity of host. In this study, a neuroendocrine immunomodulatory axis (NIA)-like pathway mediated by the nervous system and haemocyteswas characterized in the oyster Crassostrea gigas....
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ftchinacasciocas:oai:ir.qdio.ac.cn:337002/136335 2023-05-15T15:57:35+02:00 The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas Liu, Zhaoqun Zhou, Zhi Jiang, Qiufen Wang, Lingling Yi, Qilin Qiu, Limei Song, Linsheng 2017 http://ir.qdio.ac.cn/handle/337002/136335 https://doi.org/10.1098/rsob.160289 英语 eng OPEN BIOLOGY Liu, Zhaoqun,Zhou, Zhi,Jiang, Qiufen,et al. The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas[J]. OPEN BIOLOGY,2017,7(1). http://ir.qdio.ac.cn/handle/337002/136335 doi:10.1098/rsob.160289 Crassostrea Gigas Neuroendocrine Immunomodulatory Axis Circulating Haemocyte Membrane Receptor Immune Regulation Article 期刊论文 2017 ftchinacasciocas https://doi.org/10.1098/rsob.160289 2022-06-27T05:37:51Z The neuroendocrine-immune (NEI) regulatory network is a complex system, which plays an indispensable role in the immunity of host. In this study, a neuroendocrine immunomodulatory axis (NIA)-like pathway mediated by the nervous system and haemocyteswas characterized in the oyster Crassostrea gigas. Once invaded pathogen was recognized by the host, the nervous system would temporally release neurotransmitters to modulate the immune response. Instead of acting passively, oyster haemocytes were able to mediate neuronal immunomodulation promptly by controlling the expression of specific neurotransmitter receptors on cell surface and modulating their binding sensitivities, thus regulating intracellular concentration of Ca2+. This neural immunomodulation mediated by the nervous system and haemocytes could influence cellular immunity in oyster by affecting mRNA expression level of TNF genes, and humoral immunity by affecting the activities of key immune-related enzymes. In summary, though simple in structure, the 'nervous-haemocyte' NIA-like pathway regulates both cellular and humoral immunity in oyster, meaning a world to the effective immune regulation of the NEI network. Article in Journal/Newspaper Crassostrea gigas Pacific oyster Institute of Oceanology, Chinese Academy of Sciences: IOCAS-IR Pacific Open Biology 7 1 160289 |
institution |
Open Polar |
collection |
Institute of Oceanology, Chinese Academy of Sciences: IOCAS-IR |
op_collection_id |
ftchinacasciocas |
language |
English |
topic |
Crassostrea Gigas Neuroendocrine Immunomodulatory Axis Circulating Haemocyte Membrane Receptor Immune Regulation |
spellingShingle |
Crassostrea Gigas Neuroendocrine Immunomodulatory Axis Circulating Haemocyte Membrane Receptor Immune Regulation Liu, Zhaoqun Zhou, Zhi Jiang, Qiufen Wang, Lingling Yi, Qilin Qiu, Limei Song, Linsheng The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas |
topic_facet |
Crassostrea Gigas Neuroendocrine Immunomodulatory Axis Circulating Haemocyte Membrane Receptor Immune Regulation |
description |
The neuroendocrine-immune (NEI) regulatory network is a complex system, which plays an indispensable role in the immunity of host. In this study, a neuroendocrine immunomodulatory axis (NIA)-like pathway mediated by the nervous system and haemocyteswas characterized in the oyster Crassostrea gigas. Once invaded pathogen was recognized by the host, the nervous system would temporally release neurotransmitters to modulate the immune response. Instead of acting passively, oyster haemocytes were able to mediate neuronal immunomodulation promptly by controlling the expression of specific neurotransmitter receptors on cell surface and modulating their binding sensitivities, thus regulating intracellular concentration of Ca2+. This neural immunomodulation mediated by the nervous system and haemocytes could influence cellular immunity in oyster by affecting mRNA expression level of TNF genes, and humoral immunity by affecting the activities of key immune-related enzymes. In summary, though simple in structure, the 'nervous-haemocyte' NIA-like pathway regulates both cellular and humoral immunity in oyster, meaning a world to the effective immune regulation of the NEI network. |
format |
Article in Journal/Newspaper |
author |
Liu, Zhaoqun Zhou, Zhi Jiang, Qiufen Wang, Lingling Yi, Qilin Qiu, Limei Song, Linsheng |
author_facet |
Liu, Zhaoqun Zhou, Zhi Jiang, Qiufen Wang, Lingling Yi, Qilin Qiu, Limei Song, Linsheng |
author_sort |
Liu, Zhaoqun |
title |
The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas |
title_short |
The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas |
title_full |
The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas |
title_fullStr |
The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas |
title_full_unstemmed |
The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas |
title_sort |
neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster crassostrea gigas |
publishDate |
2017 |
url |
http://ir.qdio.ac.cn/handle/337002/136335 https://doi.org/10.1098/rsob.160289 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_relation |
OPEN BIOLOGY Liu, Zhaoqun,Zhou, Zhi,Jiang, Qiufen,et al. The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas[J]. OPEN BIOLOGY,2017,7(1). http://ir.qdio.ac.cn/handle/337002/136335 doi:10.1098/rsob.160289 |
op_doi |
https://doi.org/10.1098/rsob.160289 |
container_title |
Open Biology |
container_volume |
7 |
container_issue |
1 |
container_start_page |
160289 |
_version_ |
1766393254686752768 |