A CgIFNLP receptor from Crassostrea gigas and its activation of the related genes in human JAK/STAT signaling pathway

• Published in: Developmental & Comparative Immunology
• Main Authors: Zhang, Ran, Liu, Rui, Xin, Lusheng, Chen, Hao, Li, Chenghua, Wang, Lingling, Song, Linsheng
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2016
• Subjects: Crassostrea Gigas; Interferon; Interferon Receptor; Poly (i: c); Interferon Stimulated Genes; Janus; Crassostrea gigas
• Online Access: http://ir.qdio.ac.cn/handle/337002/135895; https://doi.org/10.1016/j.dci.2016.06.010

Interferon is a highly pleiotropic cytokine, once binding to its receptors, can activate JAK kinases and STAT transcription factors to initiate the transcription of genes downstream from interferon-stimulated response elements. In the present study, a cytokine receptor-like 3 molecule was selected a...