Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection
Neutrophils constitute an essential part of the innate immune system. Recently, neutrophils have been found to produce a complex extracellular structure called neutrophil extracellular traps (NETs) that capture bacteria, fungi, and parasites. In fish, a few studies on NETs production have been repor...
Published in: | Developmental & Comparative Immunology |
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Online Access: | http://ir.qdio.ac.cn/handle/337002/112430 https://doi.org/10.1016/j.dci.2015.11.005 |
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ftchinacasciocas:oai:ir.qdio.ac.cn:337002/112430 2023-05-15T18:15:39+02:00 Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection Chi, Heng Sun, Li 2016-03-01 http://ir.qdio.ac.cn/handle/337002/112430 https://doi.org/10.1016/j.dci.2015.11.005 英语 eng DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY Chi, Heng,Sun, Li. Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2016,56(2016):7-12. http://ir.qdio.ac.cn/handle/337002/112430 doi:10.1016/j.dci.2015.11.005 Neutrophil Extracellular Trap Scophthalmus Maximus Antibacterial Innate Immune Defense Article 期刊论文 2016 ftchinacasciocas https://doi.org/10.1016/j.dci.2015.11.005 2022-06-27T05:37:26Z Neutrophils constitute an essential part of the innate immune system. Recently, neutrophils have been found to produce a complex extracellular structure called neutrophil extracellular traps (NETs) that capture bacteria, fungi, and parasites. In fish, a few studies on NETs production have been reported, however, the function of fish NETs is unknown. In this study, we examined the ability of turbot (Scophthalmus maximus) neutrophils to produce NETs and investigated the effect of turbot NETs on bacterial infection. We found that upon lipopolysaccharides treatment, turbot head kidney neutrophils produced typical NETs structures that contained DNA and histones. Bacteria treatment also induced production of NETs, which in turn entrapped the bacterial cells and inhibited bacterial replication. Furthermore, when introduced into turbot, NETS-trapped bacteria exhibited significantly weakened ability of tissue dissemination and colonization. These results indicate for the first time that teleost NETs possess apparent antibacterial effect both in vitro and in vivo. (C) 2015 Elsevier Ltd. All rights reserved. Article in Journal/Newspaper Scophthalmus maximus Turbot Institute of Oceanology, Chinese Academy of Sciences: IOCAS-IR Developmental & Comparative Immunology 56 7 12 |
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Open Polar |
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Institute of Oceanology, Chinese Academy of Sciences: IOCAS-IR |
op_collection_id |
ftchinacasciocas |
language |
English |
topic |
Neutrophil Extracellular Trap Scophthalmus Maximus Antibacterial Innate Immune Defense |
spellingShingle |
Neutrophil Extracellular Trap Scophthalmus Maximus Antibacterial Innate Immune Defense Chi, Heng Sun, Li Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection |
topic_facet |
Neutrophil Extracellular Trap Scophthalmus Maximus Antibacterial Innate Immune Defense |
description |
Neutrophils constitute an essential part of the innate immune system. Recently, neutrophils have been found to produce a complex extracellular structure called neutrophil extracellular traps (NETs) that capture bacteria, fungi, and parasites. In fish, a few studies on NETs production have been reported, however, the function of fish NETs is unknown. In this study, we examined the ability of turbot (Scophthalmus maximus) neutrophils to produce NETs and investigated the effect of turbot NETs on bacterial infection. We found that upon lipopolysaccharides treatment, turbot head kidney neutrophils produced typical NETs structures that contained DNA and histones. Bacteria treatment also induced production of NETs, which in turn entrapped the bacterial cells and inhibited bacterial replication. Furthermore, when introduced into turbot, NETS-trapped bacteria exhibited significantly weakened ability of tissue dissemination and colonization. These results indicate for the first time that teleost NETs possess apparent antibacterial effect both in vitro and in vivo. (C) 2015 Elsevier Ltd. All rights reserved. |
format |
Article in Journal/Newspaper |
author |
Chi, Heng Sun, Li |
author_facet |
Chi, Heng Sun, Li |
author_sort |
Chi, Heng |
title |
Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection |
title_short |
Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection |
title_full |
Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection |
title_fullStr |
Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection |
title_full_unstemmed |
Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection |
title_sort |
neutrophils of scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection |
publishDate |
2016 |
url |
http://ir.qdio.ac.cn/handle/337002/112430 https://doi.org/10.1016/j.dci.2015.11.005 |
genre |
Scophthalmus maximus Turbot |
genre_facet |
Scophthalmus maximus Turbot |
op_relation |
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY Chi, Heng,Sun, Li. Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2016,56(2016):7-12. http://ir.qdio.ac.cn/handle/337002/112430 doi:10.1016/j.dci.2015.11.005 |
op_doi |
https://doi.org/10.1016/j.dci.2015.11.005 |
container_title |
Developmental & Comparative Immunology |
container_volume |
56 |
container_start_page |
7 |
op_container_end_page |
12 |
_version_ |
1766188821266825216 |