Research progress on gut health of farmers teleost fish: a viewpoint concerning the intestinal mucosal barrier and the impact of its damage

• Published in: Reviews in Fish Biology and Fisheries
• Main Authors: Zhang, Hongling, Ran, Chao, Teame, Tsegay, Ding, Qianwen, Hoseinifar, Seyed Hossein, Xie, Mingxu, Zhang, Zhen, Yang, Yalin, Olsen, Rolf Erik, Gatlin, Delbert M., III, Ringo, Einar, Duan, Ming, Zhou, Zhigang
• Format: Report
• Language: English
• Published: SPRINGER 2020
• Subjects: Teleost fish; Gut health; Intestinal mucosal barrier; Damage; Gut microbiota; Cell death; Fisheries; Marine & Freshwater Biology; CARP CTENOPHARYNGODON-IDELLA; SALMO-SALAR L; NF-KAPPA-B; ENDOPLASMIC-RETICULUM-STRESS; MESSENGER-RNA EXPRESSION; ATLANTIC SALMON; RAINBOW-TROUT; CELL-DEATH; SECONDARY NECROSIS; IMMUNE FUNCTION; Atlantic salmon; Salmo salar
• Online Access: http://ir.ihb.ac.cn/handle/342005/36780; http://ir.ihb.ac.cn/handle/342005/36781; https://doi.org/10.1007/s11160-020-09614-y

The intestinal mucosal barrier plays a critical role in the maintenance of host health. In farmed teleost fish, the intestinal epithelium is challenged by a number of factors, leading to damage of the intestinal mucosal barrier. The pathogenesis of intestinal mucosal barrier damage in most farmed teleost fish has been associated with cell death, mainly including apoptosis, pyroptosis, necroptosis as well as secondary injury by cell lysis. However, the mechanisms behind intestinal mucosal barrier damage are not well studied. Here we summarized the factors causing damage of intestinal mucosal barrier in fish. Further we discussed the intracellular and interstitial signaling cascades, with special emphasis on cell death that potentially accelerates the progression of intestinal injury. Deeper understanding of the mechanisms of intestinal mucosal barrier damage may facilitate the development of potential intervention strategies for intestinal diseases in farmed teleost fish.