Anti-foodborne enteritis effect of galantamine potentially via acetylcholine anti-inflammatory pathway in fish
Foodbome enteritis has become a limiting factor in aquaculture. Plant protein sources have already caused enteritic inflammation and inhibition in growth performance. Attempts have been made to find an effective solution to foodbome enteritis. Based on the previously suggested fish cholinergic anti-...
Published in: | Fish & Shellfish Immunology |
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2020
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Online Access: | http://ir.ihb.ac.cn/handle/342005/35077 http://ir.ihb.ac.cn/handle/342005/35078 https://doi.org/10.1016/j.fsi.2019.12.028 |
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ftchinacadsciihb:oai:ir.ihb.ac.cn:342005/35078 2023-05-15T15:32:39+02:00 Anti-foodborne enteritis effect of galantamine potentially via acetylcholine anti-inflammatory pathway in fish Wu, Nan Xu, Xuan Wang, Biao Li, Xian-Mei Cheng, Ying-Yin Li, Ming Xia, Xiao-Qin Zhang, Yong-An 2020-02-01 http://ir.ihb.ac.cn/handle/342005/35077 http://ir.ihb.ac.cn/handle/342005/35078 https://doi.org/10.1016/j.fsi.2019.12.028 英语 eng ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD FISH & SHELLFISH IMMUNOLOGY http://ir.ihb.ac.cn/handle/342005/35077 http://ir.ihb.ac.cn/handle/342005/35078 doi:10.1016/j.fsi.2019.12.028 Fish foodbome enteritis Galantamine Acetylcholine anti-inflammatory pathway Fisheries Immunology Marine & Freshwater Biology Veterinary Sciences EUROPEAN SEA-BASS DICENTRARCHUS-LABRAX IMMUNE-RESPONSE ATLANTIC SALMON MEAL EXPRESSION GENE INVOLVEMENT POPULATIONS ACTIVATION 期刊论文 2020 ftchinacadsciihb https://doi.org/10.1016/j.fsi.2019.12.028 2020-05-01T00:06:18Z Foodbome enteritis has become a limiting factor in aquaculture. Plant protein sources have already caused enteritic inflammation and inhibition in growth performance. Attempts have been made to find an effective solution to foodbome enteritis. Based on the previously suggested fish cholinergic anti-inflammatory pathway, galantamine, a typical cholinesterase inhibitor, was tested for the repression of pro-inflammatory cytokines for soybean meal induced enteritis by injection into grass carp. Both the phylogenetic analysis of cholinesterase, AchR and bioinformatic prediction, indicated galantamine's potential use as an enteritis drug. The result highlighted galantamine's potential effect for anti-enteritis in fish, especially in carps. Subsequently, a 4-week feeding trail using galantamine as an additive, in a zebrafish soybean meal induced enteritis model, demonstrated the prevention of enteritis. The results demonstrated that galantamine could prevent intestinal pathology, both histologically and molecularly, and also maintain growth performance. Reflected by gene expressional analysis, all mechanical, chemical and immune functions of the intestinal barrier could be protected by galantamine supplementation, which aided molecularly in the control of fish foodbome enteritis, through down-regulating Th17 type proinflammatory factors, meanwhile resuming the level of Treg type anti-inflammatory factors. Therefore, the current results shed light on fish intestinal acetylcholine anti-inflammation, by the dietary addition of galantamine, which could give rise to protection from foodbome enteritis. Report Atlantic salmon Institute of Hydrobiology, Chinese Academy of Sciences: IHB OpenIR Fish & Shellfish Immunology 97 204 215 |
institution |
Open Polar |
collection |
Institute of Hydrobiology, Chinese Academy of Sciences: IHB OpenIR |
op_collection_id |
ftchinacadsciihb |
language |
English |
topic |
Fish foodbome enteritis Galantamine Acetylcholine anti-inflammatory pathway Fisheries Immunology Marine & Freshwater Biology Veterinary Sciences EUROPEAN SEA-BASS DICENTRARCHUS-LABRAX IMMUNE-RESPONSE ATLANTIC SALMON MEAL EXPRESSION GENE INVOLVEMENT POPULATIONS ACTIVATION |
spellingShingle |
Fish foodbome enteritis Galantamine Acetylcholine anti-inflammatory pathway Fisheries Immunology Marine & Freshwater Biology Veterinary Sciences EUROPEAN SEA-BASS DICENTRARCHUS-LABRAX IMMUNE-RESPONSE ATLANTIC SALMON MEAL EXPRESSION GENE INVOLVEMENT POPULATIONS ACTIVATION Wu, Nan Xu, Xuan Wang, Biao Li, Xian-Mei Cheng, Ying-Yin Li, Ming Xia, Xiao-Qin Zhang, Yong-An Anti-foodborne enteritis effect of galantamine potentially via acetylcholine anti-inflammatory pathway in fish |
topic_facet |
Fish foodbome enteritis Galantamine Acetylcholine anti-inflammatory pathway Fisheries Immunology Marine & Freshwater Biology Veterinary Sciences EUROPEAN SEA-BASS DICENTRARCHUS-LABRAX IMMUNE-RESPONSE ATLANTIC SALMON MEAL EXPRESSION GENE INVOLVEMENT POPULATIONS ACTIVATION |
description |
Foodbome enteritis has become a limiting factor in aquaculture. Plant protein sources have already caused enteritic inflammation and inhibition in growth performance. Attempts have been made to find an effective solution to foodbome enteritis. Based on the previously suggested fish cholinergic anti-inflammatory pathway, galantamine, a typical cholinesterase inhibitor, was tested for the repression of pro-inflammatory cytokines for soybean meal induced enteritis by injection into grass carp. Both the phylogenetic analysis of cholinesterase, AchR and bioinformatic prediction, indicated galantamine's potential use as an enteritis drug. The result highlighted galantamine's potential effect for anti-enteritis in fish, especially in carps. Subsequently, a 4-week feeding trail using galantamine as an additive, in a zebrafish soybean meal induced enteritis model, demonstrated the prevention of enteritis. The results demonstrated that galantamine could prevent intestinal pathology, both histologically and molecularly, and also maintain growth performance. Reflected by gene expressional analysis, all mechanical, chemical and immune functions of the intestinal barrier could be protected by galantamine supplementation, which aided molecularly in the control of fish foodbome enteritis, through down-regulating Th17 type proinflammatory factors, meanwhile resuming the level of Treg type anti-inflammatory factors. Therefore, the current results shed light on fish intestinal acetylcholine anti-inflammation, by the dietary addition of galantamine, which could give rise to protection from foodbome enteritis. |
format |
Report |
author |
Wu, Nan Xu, Xuan Wang, Biao Li, Xian-Mei Cheng, Ying-Yin Li, Ming Xia, Xiao-Qin Zhang, Yong-An |
author_facet |
Wu, Nan Xu, Xuan Wang, Biao Li, Xian-Mei Cheng, Ying-Yin Li, Ming Xia, Xiao-Qin Zhang, Yong-An |
author_sort |
Wu, Nan |
title |
Anti-foodborne enteritis effect of galantamine potentially via acetylcholine anti-inflammatory pathway in fish |
title_short |
Anti-foodborne enteritis effect of galantamine potentially via acetylcholine anti-inflammatory pathway in fish |
title_full |
Anti-foodborne enteritis effect of galantamine potentially via acetylcholine anti-inflammatory pathway in fish |
title_fullStr |
Anti-foodborne enteritis effect of galantamine potentially via acetylcholine anti-inflammatory pathway in fish |
title_full_unstemmed |
Anti-foodborne enteritis effect of galantamine potentially via acetylcholine anti-inflammatory pathway in fish |
title_sort |
anti-foodborne enteritis effect of galantamine potentially via acetylcholine anti-inflammatory pathway in fish |
publisher |
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
publishDate |
2020 |
url |
http://ir.ihb.ac.cn/handle/342005/35077 http://ir.ihb.ac.cn/handle/342005/35078 https://doi.org/10.1016/j.fsi.2019.12.028 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_relation |
FISH & SHELLFISH IMMUNOLOGY http://ir.ihb.ac.cn/handle/342005/35077 http://ir.ihb.ac.cn/handle/342005/35078 doi:10.1016/j.fsi.2019.12.028 |
op_doi |
https://doi.org/10.1016/j.fsi.2019.12.028 |
container_title |
Fish & Shellfish Immunology |
container_volume |
97 |
container_start_page |
204 |
op_container_end_page |
215 |
_version_ |
1766363145740222464 |