Polymorphisms in the Myostatin-1 gene and their association with growth traits in Ancherythroculter nigrocauda
Myostatin (MSTN) is a member of the transforming growth factor-beta gene superfamily that negatively regulates skeletal muscle development and growth. In the present study, partial genomic fragments of Myostatin-1 (MSTN-1) in two commercial hatchery populations of Ancherythroculter nigrocauda, an ec...
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Online Access: | http://ir.ihb.ac.cn/handle/342005/32768 http://ir.ihb.ac.cn/handle/342005/32769 https://doi.org/10.1007/s00343-017-5317-0 |
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ftchinacadsciihb:oai:ir.ihb.ac.cn:342005/32769 2023-05-15T18:09:55+02:00 Polymorphisms in the Myostatin-1 gene and their association with growth traits in Ancherythroculter nigrocauda Sun Yanhong Li Qing Wang Guiying Zhu Dongmei Chen Jian Li Pei Tong Jingou 2017-05-01 http://ir.ihb.ac.cn/handle/342005/32768 http://ir.ihb.ac.cn/handle/342005/32769 https://doi.org/10.1007/s00343-017-5317-0 英语 eng SCIENCE PRESS CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY http://ir.ihb.ac.cn/handle/342005/32768 http://ir.ihb.ac.cn/handle/342005/32769 doi:10.1007/s00343-017-5317-0 Myostatin-1 (MSTN-1) single nucleotide polymorphisms ( SNPs) Ancherythroculter nigrocauda growth traits association analysis Marine & Freshwater Biology Oceanography Limnology SALMON SALMO-SALAR MARKER ASSISTED SELECTION MSTN GENE IDENTIFICATION REGION SNP WEIGHT CATTLE 期刊论文 2017 ftchinacadsciihb https://doi.org/10.1007/s00343-017-5317-0 2019-10-04T00:04:20Z Myostatin (MSTN) is a member of the transforming growth factor-beta gene superfamily that negatively regulates skeletal muscle development and growth. In the present study, partial genomic fragments of Myostatin-1 (MSTN-1) in two commercial hatchery populations of Ancherythroculter nigrocauda, an economically important freshwater fish, were screened for single nucleotide polymorphisms (SNPs) and then genotyped by direct sequencing of PCR products. Five SNPs were identified in intron 1 and exon 2, including a non-synonymous mutation causing an amino acid change (Val to Ile) at position 180. Association analyses based on 300 individuals revealed that the g.1129T > C SNP locus was significantly associated with total length (TL), body length (BL), body height (BH) and body weight (BW) in 6- and 18-month-old populations, while the g.1289G > A locus was significantly associated with BH and BW in the 6-month-old population. Haplotype analyses revealed that fish with the genotype combinations TC/TC or TC/GA showed better growth performance. Our results suggest that g.1129T > C and g.1289G > A have positive effects on growth traits and may be candidate gene markers for marker-assisted selection in A. nigrocauda. Report Salmo salar Institute of Hydrobiology, Chinese Academy of Sciences: IHB OpenIR Chinese Journal of Oceanology and Limnology 35 3 597 602 |
institution |
Open Polar |
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Institute of Hydrobiology, Chinese Academy of Sciences: IHB OpenIR |
op_collection_id |
ftchinacadsciihb |
language |
English |
topic |
Myostatin-1 (MSTN-1) single nucleotide polymorphisms ( SNPs) Ancherythroculter nigrocauda growth traits association analysis Marine & Freshwater Biology Oceanography Limnology SALMON SALMO-SALAR MARKER ASSISTED SELECTION MSTN GENE IDENTIFICATION REGION SNP WEIGHT CATTLE |
spellingShingle |
Myostatin-1 (MSTN-1) single nucleotide polymorphisms ( SNPs) Ancherythroculter nigrocauda growth traits association analysis Marine & Freshwater Biology Oceanography Limnology SALMON SALMO-SALAR MARKER ASSISTED SELECTION MSTN GENE IDENTIFICATION REGION SNP WEIGHT CATTLE Sun Yanhong Li Qing Wang Guiying Zhu Dongmei Chen Jian Li Pei Tong Jingou Polymorphisms in the Myostatin-1 gene and their association with growth traits in Ancherythroculter nigrocauda |
topic_facet |
Myostatin-1 (MSTN-1) single nucleotide polymorphisms ( SNPs) Ancherythroculter nigrocauda growth traits association analysis Marine & Freshwater Biology Oceanography Limnology SALMON SALMO-SALAR MARKER ASSISTED SELECTION MSTN GENE IDENTIFICATION REGION SNP WEIGHT CATTLE |
description |
Myostatin (MSTN) is a member of the transforming growth factor-beta gene superfamily that negatively regulates skeletal muscle development and growth. In the present study, partial genomic fragments of Myostatin-1 (MSTN-1) in two commercial hatchery populations of Ancherythroculter nigrocauda, an economically important freshwater fish, were screened for single nucleotide polymorphisms (SNPs) and then genotyped by direct sequencing of PCR products. Five SNPs were identified in intron 1 and exon 2, including a non-synonymous mutation causing an amino acid change (Val to Ile) at position 180. Association analyses based on 300 individuals revealed that the g.1129T > C SNP locus was significantly associated with total length (TL), body length (BL), body height (BH) and body weight (BW) in 6- and 18-month-old populations, while the g.1289G > A locus was significantly associated with BH and BW in the 6-month-old population. Haplotype analyses revealed that fish with the genotype combinations TC/TC or TC/GA showed better growth performance. Our results suggest that g.1129T > C and g.1289G > A have positive effects on growth traits and may be candidate gene markers for marker-assisted selection in A. nigrocauda. |
format |
Report |
author |
Sun Yanhong Li Qing Wang Guiying Zhu Dongmei Chen Jian Li Pei Tong Jingou |
author_facet |
Sun Yanhong Li Qing Wang Guiying Zhu Dongmei Chen Jian Li Pei Tong Jingou |
author_sort |
Sun Yanhong |
title |
Polymorphisms in the Myostatin-1 gene and their association with growth traits in Ancherythroculter nigrocauda |
title_short |
Polymorphisms in the Myostatin-1 gene and their association with growth traits in Ancherythroculter nigrocauda |
title_full |
Polymorphisms in the Myostatin-1 gene and their association with growth traits in Ancherythroculter nigrocauda |
title_fullStr |
Polymorphisms in the Myostatin-1 gene and their association with growth traits in Ancherythroculter nigrocauda |
title_full_unstemmed |
Polymorphisms in the Myostatin-1 gene and their association with growth traits in Ancherythroculter nigrocauda |
title_sort |
polymorphisms in the myostatin-1 gene and their association with growth traits in ancherythroculter nigrocauda |
publisher |
SCIENCE PRESS |
publishDate |
2017 |
url |
http://ir.ihb.ac.cn/handle/342005/32768 http://ir.ihb.ac.cn/handle/342005/32769 https://doi.org/10.1007/s00343-017-5317-0 |
genre |
Salmo salar |
genre_facet |
Salmo salar |
op_relation |
CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY http://ir.ihb.ac.cn/handle/342005/32768 http://ir.ihb.ac.cn/handle/342005/32769 doi:10.1007/s00343-017-5317-0 |
op_doi |
https://doi.org/10.1007/s00343-017-5317-0 |
container_title |
Chinese Journal of Oceanology and Limnology |
container_volume |
35 |
container_issue |
3 |
container_start_page |
597 |
op_container_end_page |
602 |
_version_ |
1766182615107239936 |