Hematologic and Biochemical Reference Interval Development and the Effect of Age, Sex, Season, and Location on Hematologic Analyte Concentrations in Critically Endangered Yangtze Finless Porpoise (Neophocaena asiaeorientalis ssp. asiaeorientalis )
In this study, references intervals for 49 clinicopathological parameters were established for the critically endangered Yangtze finless porpoise (YFP) (Neophocaena phocaenoides asiaorientalis). Both from the wild (Poyang Lake) and seminatural (TianE-Zhou Oxbow) populations, individual blood samples...
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2019
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Online Access: | http://ir.ihb.ac.cn/handle/342005/31743 http://ir.ihb.ac.cn/handle/342005/31744 https://doi.org/10.3389/fphys.2019.00792 |
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ftchinacadsciihb:oai:ir.ihb.ac.cn:342005/31744 2023-05-15T15:41:55+02:00 Hematologic and Biochemical Reference Interval Development and the Effect of Age, Sex, Season, and Location on Hematologic Analyte Concentrations in Critically Endangered Yangtze Finless Porpoise (Neophocaena asiaeorientalis ssp. asiaeorientalis ) Nabi, Ghulam Robeck, Todd R. Hao, Yujiang Wang, Ding 2019-07-11 http://ir.ihb.ac.cn/handle/342005/31743 http://ir.ihb.ac.cn/handle/342005/31744 https://doi.org/10.3389/fphys.2019.00792 英语 eng FRONTIERS MEDIA SA FRONTIERS IN PHYSIOLOGY http://ir.ihb.ac.cn/handle/342005/31743 http://ir.ihb.ac.cn/handle/342005/31744 doi:10.3389/fphys.2019.00792 clinicopathological critically endangered Poyang Lake reference interval Yangtze finless porpoise Physiology BOTTLE-NOSED DOLPHINS WHALES DELPHINAPTERUS-LEUCAS SERUM CHEMISTRY TURSIOPS-TRUNCATUS BLOOD-CHEMISTRY BELUGA WHALES PLASMA BIOCHEMISTRY VALUES SEALS BAY 期刊论文 2019 ftchinacadsciihb https://doi.org/10.3389/fphys.2019.00792 2019-08-23T00:03:48Z In this study, references intervals for 49 clinicopathological parameters were established for the critically endangered Yangtze finless porpoise (YFP) (Neophocaena phocaenoides asiaorientalis). Both from the wild (Poyang Lake) and seminatural (TianE-Zhou Oxbow) populations, individual blood samples from 188 animals were collected from 2009 to 2017 and from 2002 to 2015, respectively. For reference interval determination, we used a non-parametric bootstrap-based procedure to determine the 95th percentiles and the associated 90% confidence interval for each analyte. Our results indicated a need to partition the analyte concentrations by sex, age group, or pregnancy; however, we did not find a need to partition results by location. We then used a linear mixed model to determine if evidence existed for mean differences between location with sex and season as covariates and age group as the clustered random variable on mean hematological parameters in the YFP. We found that 88% of the analytes were significantly different between locations. Within the covariates, sex and season showed 31 and 69% significant difference in mean distributions, respectively. Additionally, age group provided a significant source of variation in 25% of the analytes. In summary, our finding suggests that analytes should be grouped according sex, age, and reproductive status (non-pregnant and non-lactating, pregnant and lactating). Furthermore, we have provided the first set of reference intervals for 49 clinicopathological parameters that could provide guidelines for the initial evaluation of individuals during health assessments. Report Beluga Beluga* Delphinapterus leucas Institute of Hydrobiology, Chinese Academy of Sciences: IHB OpenIR Frontiers in Physiology 10 |
institution |
Open Polar |
collection |
Institute of Hydrobiology, Chinese Academy of Sciences: IHB OpenIR |
op_collection_id |
ftchinacadsciihb |
language |
English |
topic |
clinicopathological critically endangered Poyang Lake reference interval Yangtze finless porpoise Physiology BOTTLE-NOSED DOLPHINS WHALES DELPHINAPTERUS-LEUCAS SERUM CHEMISTRY TURSIOPS-TRUNCATUS BLOOD-CHEMISTRY BELUGA WHALES PLASMA BIOCHEMISTRY VALUES SEALS BAY |
spellingShingle |
clinicopathological critically endangered Poyang Lake reference interval Yangtze finless porpoise Physiology BOTTLE-NOSED DOLPHINS WHALES DELPHINAPTERUS-LEUCAS SERUM CHEMISTRY TURSIOPS-TRUNCATUS BLOOD-CHEMISTRY BELUGA WHALES PLASMA BIOCHEMISTRY VALUES SEALS BAY Nabi, Ghulam Robeck, Todd R. Hao, Yujiang Wang, Ding Hematologic and Biochemical Reference Interval Development and the Effect of Age, Sex, Season, and Location on Hematologic Analyte Concentrations in Critically Endangered Yangtze Finless Porpoise (Neophocaena asiaeorientalis ssp. asiaeorientalis ) |
topic_facet |
clinicopathological critically endangered Poyang Lake reference interval Yangtze finless porpoise Physiology BOTTLE-NOSED DOLPHINS WHALES DELPHINAPTERUS-LEUCAS SERUM CHEMISTRY TURSIOPS-TRUNCATUS BLOOD-CHEMISTRY BELUGA WHALES PLASMA BIOCHEMISTRY VALUES SEALS BAY |
description |
In this study, references intervals for 49 clinicopathological parameters were established for the critically endangered Yangtze finless porpoise (YFP) (Neophocaena phocaenoides asiaorientalis). Both from the wild (Poyang Lake) and seminatural (TianE-Zhou Oxbow) populations, individual blood samples from 188 animals were collected from 2009 to 2017 and from 2002 to 2015, respectively. For reference interval determination, we used a non-parametric bootstrap-based procedure to determine the 95th percentiles and the associated 90% confidence interval for each analyte. Our results indicated a need to partition the analyte concentrations by sex, age group, or pregnancy; however, we did not find a need to partition results by location. We then used a linear mixed model to determine if evidence existed for mean differences between location with sex and season as covariates and age group as the clustered random variable on mean hematological parameters in the YFP. We found that 88% of the analytes were significantly different between locations. Within the covariates, sex and season showed 31 and 69% significant difference in mean distributions, respectively. Additionally, age group provided a significant source of variation in 25% of the analytes. In summary, our finding suggests that analytes should be grouped according sex, age, and reproductive status (non-pregnant and non-lactating, pregnant and lactating). Furthermore, we have provided the first set of reference intervals for 49 clinicopathological parameters that could provide guidelines for the initial evaluation of individuals during health assessments. |
format |
Report |
author |
Nabi, Ghulam Robeck, Todd R. Hao, Yujiang Wang, Ding |
author_facet |
Nabi, Ghulam Robeck, Todd R. Hao, Yujiang Wang, Ding |
author_sort |
Nabi, Ghulam |
title |
Hematologic and Biochemical Reference Interval Development and the Effect of Age, Sex, Season, and Location on Hematologic Analyte Concentrations in Critically Endangered Yangtze Finless Porpoise (Neophocaena asiaeorientalis ssp. asiaeorientalis ) |
title_short |
Hematologic and Biochemical Reference Interval Development and the Effect of Age, Sex, Season, and Location on Hematologic Analyte Concentrations in Critically Endangered Yangtze Finless Porpoise (Neophocaena asiaeorientalis ssp. asiaeorientalis ) |
title_full |
Hematologic and Biochemical Reference Interval Development and the Effect of Age, Sex, Season, and Location on Hematologic Analyte Concentrations in Critically Endangered Yangtze Finless Porpoise (Neophocaena asiaeorientalis ssp. asiaeorientalis ) |
title_fullStr |
Hematologic and Biochemical Reference Interval Development and the Effect of Age, Sex, Season, and Location on Hematologic Analyte Concentrations in Critically Endangered Yangtze Finless Porpoise (Neophocaena asiaeorientalis ssp. asiaeorientalis ) |
title_full_unstemmed |
Hematologic and Biochemical Reference Interval Development and the Effect of Age, Sex, Season, and Location on Hematologic Analyte Concentrations in Critically Endangered Yangtze Finless Porpoise (Neophocaena asiaeorientalis ssp. asiaeorientalis ) |
title_sort |
hematologic and biochemical reference interval development and the effect of age, sex, season, and location on hematologic analyte concentrations in critically endangered yangtze finless porpoise (neophocaena asiaeorientalis ssp. asiaeorientalis ) |
publisher |
FRONTIERS MEDIA SA |
publishDate |
2019 |
url |
http://ir.ihb.ac.cn/handle/342005/31743 http://ir.ihb.ac.cn/handle/342005/31744 https://doi.org/10.3389/fphys.2019.00792 |
genre |
Beluga Beluga* Delphinapterus leucas |
genre_facet |
Beluga Beluga* Delphinapterus leucas |
op_relation |
FRONTIERS IN PHYSIOLOGY http://ir.ihb.ac.cn/handle/342005/31743 http://ir.ihb.ac.cn/handle/342005/31744 doi:10.3389/fphys.2019.00792 |
op_doi |
https://doi.org/10.3389/fphys.2019.00792 |
container_title |
Frontiers in Physiology |
container_volume |
10 |
_version_ |
1766374795690115072 |