Beluga whale pVHL enhances HIF-2 alpha activity via inducing HIF-2 alpha proteasomal degradation under hypoxia
Aquatic mammals, such as cetaceans experience various depths, with accordingly diverse oxygenation, thus, cetaceans have developed adaptations for hypoxia, but mechanisms underlying this tolerance to low oxygen are unclear. Here we analyzed VHL and HIF-2 alpha, in the hypoxia signaling pathway. Vari...
Published in: | Oncotarget |
---|---|
Main Authors: | , , , , , , |
Format: | Report |
Language: | English |
Published: |
IMPACT JOURNALS LLC
2017
|
Subjects: | |
Online Access: | http://ir.ihb.ac.cn/handle/342005/31444 http://ir.ihb.ac.cn/handle/342005/31445 https://doi.org/10.18632/oncotarget.15038 |
id |
ftchinacadsciihb:oai:ir.ihb.ac.cn:342005/31445 |
---|---|
record_format |
openpolar |
spelling |
ftchinacadsciihb:oai:ir.ihb.ac.cn:342005/31445 2023-05-15T15:41:40+02:00 Beluga whale pVHL enhances HIF-2 alpha activity via inducing HIF-2 alpha proteasomal degradation under hypoxia Bi, Jianling Hu, Bo Wang, Jing Liu, Xing Zheng, Jinsong Wang, Ding Xiao, Wuhan 2017-06-27 http://ir.ihb.ac.cn/handle/342005/31444 http://ir.ihb.ac.cn/handle/342005/31445 https://doi.org/10.18632/oncotarget.15038 英语 eng IMPACT JOURNALS LLC ONCOTARGET http://ir.ihb.ac.cn/handle/342005/31444 http://ir.ihb.ac.cn/handle/342005/31445 doi:10.18632/oncotarget.15038 beluga whale cetaceans hypoxia HIF-2 alpha VHL Oncology Cell Biology TUMOR-SUPPRESSOR PROTEIN HIGH-ALTITUDE ADAPTATION BAIJI LIPOTES-VEXILLIFER DELPHINAPTERUS-LEUCAS HIF-ALPHA MOLE-RAT FINLESS PORPOISE DIVING BEHAVIOR YANGTZE-RIVER WHITE WHALES 期刊论文 2017 ftchinacadsciihb https://doi.org/10.18632/oncotarget.15038 2019-08-23T00:03:47Z Aquatic mammals, such as cetaceans experience various depths, with accordingly diverse oxygenation, thus, cetaceans have developed adaptations for hypoxia, but mechanisms underlying this tolerance to low oxygen are unclear. Here we analyzed VHL and HIF-2 alpha, in the hypoxia signaling pathway. Variations in VHL are greater than HIF-2 alpha between cetaceans and terrestrial mammals, and beluga whale VHL (BW-VHL) promotes HIF-2 alpha degradation under hypoxia. BW-VHL catalyzes BW-HIF-2 alpha to form K48-linked polyubiquitin chains mainly at the lysine 429 of BW-HIF-2 alpha (K429) and induces BW-HIF-2 alpha for proteasomal degradation. W100 within BW-VHL is a key site for BW-VHL functionally and BW-VHL enhances transcriptional activity of BW-HIF-2 alpha under hypoxia. Our data therefore reveal that BW-VHL has a unique function that may contribute to hypoxic adaptation. Report Beluga Beluga whale Beluga* Delphinapterus leucas Institute of Hydrobiology, Chinese Academy of Sciences: IHB OpenIR Oncotarget 8 26 42272 42287 |
institution |
Open Polar |
collection |
Institute of Hydrobiology, Chinese Academy of Sciences: IHB OpenIR |
op_collection_id |
ftchinacadsciihb |
language |
English |
topic |
beluga whale cetaceans hypoxia HIF-2 alpha VHL Oncology Cell Biology TUMOR-SUPPRESSOR PROTEIN HIGH-ALTITUDE ADAPTATION BAIJI LIPOTES-VEXILLIFER DELPHINAPTERUS-LEUCAS HIF-ALPHA MOLE-RAT FINLESS PORPOISE DIVING BEHAVIOR YANGTZE-RIVER WHITE WHALES |
spellingShingle |
beluga whale cetaceans hypoxia HIF-2 alpha VHL Oncology Cell Biology TUMOR-SUPPRESSOR PROTEIN HIGH-ALTITUDE ADAPTATION BAIJI LIPOTES-VEXILLIFER DELPHINAPTERUS-LEUCAS HIF-ALPHA MOLE-RAT FINLESS PORPOISE DIVING BEHAVIOR YANGTZE-RIVER WHITE WHALES Bi, Jianling Hu, Bo Wang, Jing Liu, Xing Zheng, Jinsong Wang, Ding Xiao, Wuhan Beluga whale pVHL enhances HIF-2 alpha activity via inducing HIF-2 alpha proteasomal degradation under hypoxia |
topic_facet |
beluga whale cetaceans hypoxia HIF-2 alpha VHL Oncology Cell Biology TUMOR-SUPPRESSOR PROTEIN HIGH-ALTITUDE ADAPTATION BAIJI LIPOTES-VEXILLIFER DELPHINAPTERUS-LEUCAS HIF-ALPHA MOLE-RAT FINLESS PORPOISE DIVING BEHAVIOR YANGTZE-RIVER WHITE WHALES |
description |
Aquatic mammals, such as cetaceans experience various depths, with accordingly diverse oxygenation, thus, cetaceans have developed adaptations for hypoxia, but mechanisms underlying this tolerance to low oxygen are unclear. Here we analyzed VHL and HIF-2 alpha, in the hypoxia signaling pathway. Variations in VHL are greater than HIF-2 alpha between cetaceans and terrestrial mammals, and beluga whale VHL (BW-VHL) promotes HIF-2 alpha degradation under hypoxia. BW-VHL catalyzes BW-HIF-2 alpha to form K48-linked polyubiquitin chains mainly at the lysine 429 of BW-HIF-2 alpha (K429) and induces BW-HIF-2 alpha for proteasomal degradation. W100 within BW-VHL is a key site for BW-VHL functionally and BW-VHL enhances transcriptional activity of BW-HIF-2 alpha under hypoxia. Our data therefore reveal that BW-VHL has a unique function that may contribute to hypoxic adaptation. |
format |
Report |
author |
Bi, Jianling Hu, Bo Wang, Jing Liu, Xing Zheng, Jinsong Wang, Ding Xiao, Wuhan |
author_facet |
Bi, Jianling Hu, Bo Wang, Jing Liu, Xing Zheng, Jinsong Wang, Ding Xiao, Wuhan |
author_sort |
Bi, Jianling |
title |
Beluga whale pVHL enhances HIF-2 alpha activity via inducing HIF-2 alpha proteasomal degradation under hypoxia |
title_short |
Beluga whale pVHL enhances HIF-2 alpha activity via inducing HIF-2 alpha proteasomal degradation under hypoxia |
title_full |
Beluga whale pVHL enhances HIF-2 alpha activity via inducing HIF-2 alpha proteasomal degradation under hypoxia |
title_fullStr |
Beluga whale pVHL enhances HIF-2 alpha activity via inducing HIF-2 alpha proteasomal degradation under hypoxia |
title_full_unstemmed |
Beluga whale pVHL enhances HIF-2 alpha activity via inducing HIF-2 alpha proteasomal degradation under hypoxia |
title_sort |
beluga whale pvhl enhances hif-2 alpha activity via inducing hif-2 alpha proteasomal degradation under hypoxia |
publisher |
IMPACT JOURNALS LLC |
publishDate |
2017 |
url |
http://ir.ihb.ac.cn/handle/342005/31444 http://ir.ihb.ac.cn/handle/342005/31445 https://doi.org/10.18632/oncotarget.15038 |
genre |
Beluga Beluga whale Beluga* Delphinapterus leucas |
genre_facet |
Beluga Beluga whale Beluga* Delphinapterus leucas |
op_relation |
ONCOTARGET http://ir.ihb.ac.cn/handle/342005/31444 http://ir.ihb.ac.cn/handle/342005/31445 doi:10.18632/oncotarget.15038 |
op_doi |
https://doi.org/10.18632/oncotarget.15038 |
container_title |
Oncotarget |
container_volume |
8 |
container_issue |
26 |
container_start_page |
42272 |
op_container_end_page |
42287 |
_version_ |
1766374557376053248 |