Quantitative trait loci mapping for feed conversion efficiency in crucian carp (Carassius auratus)

QTL is a chromosomal region including single gene or gene clusters that determine a quantitative trait. While feed efficiency is highly important in aquaculture fish, little genetic and genomic progresses have been made for this trait. In this study, we constructed a high-resolution genetic linkage...

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Bibliographic Details
Published in:Scientific Reports
Main Authors: Pang, Meixia, Fu, Beide, Yu, Xiaomu, Liu, Haiyang, Wang, Xinhua, Yin, Zhan, Xie, Shouqi, Tong, Jingou
Format: Report
Language:English
Published: NATURE PUBLISHING GROUP 2017
Subjects:
Science & Technology - Other Topics
Multidisciplinary Sciences
TROUT ONCORHYNCHUS-MYKISS
CHARR SALVELINUS-ALPINUS
GENOME-WIDE ASSOCIATION
SALMON SALMO-SALAR
BEEF-CATTLE
BODY-WEIGHT
GENETIC ARCHITECTURE
RAINBOW-TROUT
METHANE PRODUCTION
SEXUAL-MATURATION
Salmo salar
Salvelinus alpinus
Online Access:http://ir.ihb.ac.cn/handle/342005/30706
http://ir.ihb.ac.cn/handle/342005/30707
https://doi.org/10.1038/s41598-017-17269-2
Description
Summary:QTL is a chromosomal region including single gene or gene clusters that determine a quantitative trait. While feed efficiency is highly important in aquaculture fish, little genetic and genomic progresses have been made for this trait. In this study, we constructed a high-resolution genetic linkage map in a full-sib F1 family of crucian carp (Carassius auratus) consisting of 113 progenies with 8,460 SNP markers assigning onto 50 linkage groups (LGs). This genetic map spanned 4,047.824 cM (0.478 cM/marker) and covered 98.76% of the crucian carp genome. 35 chromosome-wide QTL affecting feed conversion efficiency (FCE, 8 QTL), relative growth rate (RGR, 9 QTL), average daily gain (ADG, 13 QTL) and average daily feed intake (ADFI, 5 QTL) were detected on 14 LGs, explaining 14.0-20.9% of the phenotypic variations. In LGs of LG16, LG25, LG36 and LG49, several QTL affecting different traits clustered together at the identical or close regions of the same linkage group. Seven candidate genes, whose biological functions may involve in the energy metabolism, digestion, biosynthesis and signal transduction, were identified from these QTL intervals by comparative genomics analysis. These results provide a basis for elucidating genetic mechanism of feed efficiency and potential marker-assisted selection in crucian carp.

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