Functional, signalling and transcriptional differences of three distinct type I IFNs in a perciform fish, the mandarin fish Siniperca chuatsi
Teleost fish are unique in having type I and type II interferons (IFNs) only, and the type I IFNs are classified into Group one and Group two based on the presence of two or four cysteines respectively, and are further classified into seven subgroups. In the present study, three distinct type I IFNs...
Published in: | Developmental & Comparative Immunology |
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Language: | English |
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Online Access: | http://ir.ihb.ac.cn/handle/342005/30343 http://ir.ihb.ac.cn/handle/342005/30344 https://doi.org/10.1016/j.dci.2018.02.008 |
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ftchinacadsciihb:oai:ir.ihb.ac.cn:342005/30344 2023-05-15T15:32:50+02:00 Functional, signalling and transcriptional differences of three distinct type I IFNs in a perciform fish, the mandarin fish Siniperca chuatsi Laghari, Zubair Ahmed Chen, Shan Nan Li, Li Huang, Bei Gan, Zhen Zhou, Ying Huo, Hui Jun Hou, Jing Nie, Pin 2018-07-01 http://ir.ihb.ac.cn/handle/342005/30343 http://ir.ihb.ac.cn/handle/342005/30344 https://doi.org/10.1016/j.dci.2018.02.008 英语 eng ELSEVIER SCI LTD DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY http://ir.ihb.ac.cn/handle/342005/30343 http://ir.ihb.ac.cn/handle/342005/30344 doi:10.1016/j.dci.2018.02.008 Type I IFN Cytokine receptor family B CRFB STAT1 STAT2 IRF3 IRF7 Teleost fish Fisheries Immunology Zoology KIDNEY NECROSIS VIRUS INTERFERON REGULATORY FACTOR-3 CROAKER LARIMICHTHYS-CROCEA INFECTIOUS SPLEEN ATLANTIC SALMON PARALICHTHYS-OLIVACEUS JAPANESE FLOUNDER ANTIVIRAL ACTIVITY ORYZIAS-LATIPES GENE-EXPRESSION 期刊论文 2018 ftchinacadsciihb https://doi.org/10.1016/j.dci.2018.02.008 2019-08-23T00:03:43Z Teleost fish are unique in having type I and type II interferons (IFNs) only, and the type I IFNs are classified into Group one and Group two based on the presence of two or four cysteines respectively, and are further classified into seven subgroups. In the present study, three distinct type I IFNs, IFNc, IFNd and IFNh, have been identified in the genome sequences of a perciform fish, the mandarin fish Siniperca chuatsi. These IFNs are induced following the stimulation of Polyinosinic polycytidylic acid (poly(I: C)) and Resiquimod (R848) either in vivo or in vitro. But, the infectious spleen and kidney necrosis virus (ISKNV) infection caused a delayed response of IFNs, which may be resulted from the viral inhibition of type I IFN production and related signalling. The three receptor subunits, cytokine receptor family B 1 (CRFB1), CRFB2 and CRFB5 are also expressed in a similar manner as observed for the IFNs, and IFNc, IFNd and IFNh use preferentially the receptor complex, CRFB2 and CRFB5, CRFB1 and CRFB5, CRFB1 and CRFB5 respectively for their effective signalling in the induction of IFN-stimulated genes (ISGs). Moreover, the IFNs are able to induce their own expression, and also the IRF3 and IRF7 expression, leading to the amplification of IFN cascade. It is further revealed that these three IFNs are transcribed differently by IRF7 and IRF3. The composition, function, signalling and transcription of type I IFNs have been investigated in detail in a teleost fish. (C) 2018 Elsevier Ltd. All rights reserved. Report Atlantic salmon Institute of Hydrobiology, Chinese Academy of Sciences: IHB OpenIR Developmental & Comparative Immunology 84 94 108 |
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Open Polar |
collection |
Institute of Hydrobiology, Chinese Academy of Sciences: IHB OpenIR |
op_collection_id |
ftchinacadsciihb |
language |
English |
topic |
Type I IFN Cytokine receptor family B CRFB STAT1 STAT2 IRF3 IRF7 Teleost fish Fisheries Immunology Zoology KIDNEY NECROSIS VIRUS INTERFERON REGULATORY FACTOR-3 CROAKER LARIMICHTHYS-CROCEA INFECTIOUS SPLEEN ATLANTIC SALMON PARALICHTHYS-OLIVACEUS JAPANESE FLOUNDER ANTIVIRAL ACTIVITY ORYZIAS-LATIPES GENE-EXPRESSION |
spellingShingle |
Type I IFN Cytokine receptor family B CRFB STAT1 STAT2 IRF3 IRF7 Teleost fish Fisheries Immunology Zoology KIDNEY NECROSIS VIRUS INTERFERON REGULATORY FACTOR-3 CROAKER LARIMICHTHYS-CROCEA INFECTIOUS SPLEEN ATLANTIC SALMON PARALICHTHYS-OLIVACEUS JAPANESE FLOUNDER ANTIVIRAL ACTIVITY ORYZIAS-LATIPES GENE-EXPRESSION Laghari, Zubair Ahmed Chen, Shan Nan Li, Li Huang, Bei Gan, Zhen Zhou, Ying Huo, Hui Jun Hou, Jing Nie, Pin Functional, signalling and transcriptional differences of three distinct type I IFNs in a perciform fish, the mandarin fish Siniperca chuatsi |
topic_facet |
Type I IFN Cytokine receptor family B CRFB STAT1 STAT2 IRF3 IRF7 Teleost fish Fisheries Immunology Zoology KIDNEY NECROSIS VIRUS INTERFERON REGULATORY FACTOR-3 CROAKER LARIMICHTHYS-CROCEA INFECTIOUS SPLEEN ATLANTIC SALMON PARALICHTHYS-OLIVACEUS JAPANESE FLOUNDER ANTIVIRAL ACTIVITY ORYZIAS-LATIPES GENE-EXPRESSION |
description |
Teleost fish are unique in having type I and type II interferons (IFNs) only, and the type I IFNs are classified into Group one and Group two based on the presence of two or four cysteines respectively, and are further classified into seven subgroups. In the present study, three distinct type I IFNs, IFNc, IFNd and IFNh, have been identified in the genome sequences of a perciform fish, the mandarin fish Siniperca chuatsi. These IFNs are induced following the stimulation of Polyinosinic polycytidylic acid (poly(I: C)) and Resiquimod (R848) either in vivo or in vitro. But, the infectious spleen and kidney necrosis virus (ISKNV) infection caused a delayed response of IFNs, which may be resulted from the viral inhibition of type I IFN production and related signalling. The three receptor subunits, cytokine receptor family B 1 (CRFB1), CRFB2 and CRFB5 are also expressed in a similar manner as observed for the IFNs, and IFNc, IFNd and IFNh use preferentially the receptor complex, CRFB2 and CRFB5, CRFB1 and CRFB5, CRFB1 and CRFB5 respectively for their effective signalling in the induction of IFN-stimulated genes (ISGs). Moreover, the IFNs are able to induce their own expression, and also the IRF3 and IRF7 expression, leading to the amplification of IFN cascade. It is further revealed that these three IFNs are transcribed differently by IRF7 and IRF3. The composition, function, signalling and transcription of type I IFNs have been investigated in detail in a teleost fish. (C) 2018 Elsevier Ltd. All rights reserved. |
format |
Report |
author |
Laghari, Zubair Ahmed Chen, Shan Nan Li, Li Huang, Bei Gan, Zhen Zhou, Ying Huo, Hui Jun Hou, Jing Nie, Pin |
author_facet |
Laghari, Zubair Ahmed Chen, Shan Nan Li, Li Huang, Bei Gan, Zhen Zhou, Ying Huo, Hui Jun Hou, Jing Nie, Pin |
author_sort |
Laghari, Zubair Ahmed |
title |
Functional, signalling and transcriptional differences of three distinct type I IFNs in a perciform fish, the mandarin fish Siniperca chuatsi |
title_short |
Functional, signalling and transcriptional differences of three distinct type I IFNs in a perciform fish, the mandarin fish Siniperca chuatsi |
title_full |
Functional, signalling and transcriptional differences of three distinct type I IFNs in a perciform fish, the mandarin fish Siniperca chuatsi |
title_fullStr |
Functional, signalling and transcriptional differences of three distinct type I IFNs in a perciform fish, the mandarin fish Siniperca chuatsi |
title_full_unstemmed |
Functional, signalling and transcriptional differences of three distinct type I IFNs in a perciform fish, the mandarin fish Siniperca chuatsi |
title_sort |
functional, signalling and transcriptional differences of three distinct type i ifns in a perciform fish, the mandarin fish siniperca chuatsi |
publisher |
ELSEVIER SCI LTD |
publishDate |
2018 |
url |
http://ir.ihb.ac.cn/handle/342005/30343 http://ir.ihb.ac.cn/handle/342005/30344 https://doi.org/10.1016/j.dci.2018.02.008 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_relation |
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY http://ir.ihb.ac.cn/handle/342005/30343 http://ir.ihb.ac.cn/handle/342005/30344 doi:10.1016/j.dci.2018.02.008 |
op_doi |
https://doi.org/10.1016/j.dci.2018.02.008 |
container_title |
Developmental & Comparative Immunology |
container_volume |
84 |
container_start_page |
94 |
op_container_end_page |
108 |
_version_ |
1766363315170181120 |