Identification of another primordial CD80/86 molecule in rainbow trout: Insights into the origin and evolution of CD80 and CD86 in vertebrates
In mammals, the binding of distinct costimulatory ligands CD80 and CD86 to their receptors is essential for optimal T cell activation. Previous studies have shown that only a single CD80/86 gene exists in rainbow trout (termed rtCD80/86A) and other teleost fish, suggesting that CD80 and CD86 arose b...
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ftchinacadsciihb:oai:ir.ihb.ac.cn:342005/29349 2023-05-15T15:32:43+02:00 Identification of another primordial CD80/86 molecule in rainbow trout: Insights into the origin and evolution of CD80 and CD86 in vertebrates Zhang, Xu-Jie Zhang, Xiang-Yang Wang, Peng Zhang, Yong-An 2018-12-01 http://ir.ihb.ac.cn/handle/342005/29348 http://ir.ihb.ac.cn/handle/342005/29349 https://doi.org/10.1016/j.dci.2018.08.007 英语 eng ELSEVIER SCI LTD DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY http://ir.ihb.ac.cn/handle/342005/29348 http://ir.ihb.ac.cn/handle/342005/29349 doi:10.1016/j.dci.2018.08.007 CD80/86 Duplication Evolution Rainbow trout Fisheries Immunology Zoology GENOME PROVIDES INSIGHTS PRIMITIVE TELEOST FISH B7 FAMILY COSTIMULATORY MOLECULE ONCORHYNCHUS-MYKISS TISSUE DISTRIBUTION EXPRESSION CD28 LIGANDS RECEPTORS 期刊论文 2018 ftchinacadsciihb https://doi.org/10.1016/j.dci.2018.08.007 2019-07-12T00:03:44Z In mammals, the binding of distinct costimulatory ligands CD80 and CD86 to their receptors is essential for optimal T cell activation. Previous studies have shown that only a single CD80/86 gene exists in rainbow trout (termed rtCD80/86A) and other teleost fish, suggesting that CD80 and CD86 arose by gene duplication in the tetrapod branch, after the separation of fish and tetrapods. However, in this study, another CD80/86 gene has been cloned from rainbow trout, termed rtCD80/86B. The sequence identity between trout CD80/86 is significantly higher than that between CD80 and CD86 in tetrapods, indicating that CD80 and CD86 underwent divergent evolution in vertebrates, especially in tetrapods. Gene synteny analyses showed that the CD80 and CD86 genes are closely located in the same chromosome in tetrapods. However, CD80/86 genes are located in two distinct chromosomes in rainbow trout and Atlantic salmon, suggesting that salmonid CD80/86 genes arose by the salmonid-specific whole-genome duplication (WGD) event. Expression analysis showed that rtCD80/86A was more abundant and inducible than rtCD80/86B in various tissues, indicating the important role of rtCD80/86A in trout immunity. Interestingly, we found that head kidney B cells showed higher expression level of rtCD80/86A and rtCD80/86B when compared with the other leukocytes, suggesting a potential role for trout B cells as antigen-presenting cells (APCs). Report Atlantic salmon Institute of Hydrobiology, Chinese Academy of Sciences: IHB OpenIR Developmental & Comparative Immunology 89 73 82 |
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Open Polar |
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Institute of Hydrobiology, Chinese Academy of Sciences: IHB OpenIR |
op_collection_id |
ftchinacadsciihb |
language |
English |
topic |
CD80/86 Duplication Evolution Rainbow trout Fisheries Immunology Zoology GENOME PROVIDES INSIGHTS PRIMITIVE TELEOST FISH B7 FAMILY COSTIMULATORY MOLECULE ONCORHYNCHUS-MYKISS TISSUE DISTRIBUTION EXPRESSION CD28 LIGANDS RECEPTORS |
spellingShingle |
CD80/86 Duplication Evolution Rainbow trout Fisheries Immunology Zoology GENOME PROVIDES INSIGHTS PRIMITIVE TELEOST FISH B7 FAMILY COSTIMULATORY MOLECULE ONCORHYNCHUS-MYKISS TISSUE DISTRIBUTION EXPRESSION CD28 LIGANDS RECEPTORS Zhang, Xu-Jie Zhang, Xiang-Yang Wang, Peng Zhang, Yong-An Identification of another primordial CD80/86 molecule in rainbow trout: Insights into the origin and evolution of CD80 and CD86 in vertebrates |
topic_facet |
CD80/86 Duplication Evolution Rainbow trout Fisheries Immunology Zoology GENOME PROVIDES INSIGHTS PRIMITIVE TELEOST FISH B7 FAMILY COSTIMULATORY MOLECULE ONCORHYNCHUS-MYKISS TISSUE DISTRIBUTION EXPRESSION CD28 LIGANDS RECEPTORS |
description |
In mammals, the binding of distinct costimulatory ligands CD80 and CD86 to their receptors is essential for optimal T cell activation. Previous studies have shown that only a single CD80/86 gene exists in rainbow trout (termed rtCD80/86A) and other teleost fish, suggesting that CD80 and CD86 arose by gene duplication in the tetrapod branch, after the separation of fish and tetrapods. However, in this study, another CD80/86 gene has been cloned from rainbow trout, termed rtCD80/86B. The sequence identity between trout CD80/86 is significantly higher than that between CD80 and CD86 in tetrapods, indicating that CD80 and CD86 underwent divergent evolution in vertebrates, especially in tetrapods. Gene synteny analyses showed that the CD80 and CD86 genes are closely located in the same chromosome in tetrapods. However, CD80/86 genes are located in two distinct chromosomes in rainbow trout and Atlantic salmon, suggesting that salmonid CD80/86 genes arose by the salmonid-specific whole-genome duplication (WGD) event. Expression analysis showed that rtCD80/86A was more abundant and inducible than rtCD80/86B in various tissues, indicating the important role of rtCD80/86A in trout immunity. Interestingly, we found that head kidney B cells showed higher expression level of rtCD80/86A and rtCD80/86B when compared with the other leukocytes, suggesting a potential role for trout B cells as antigen-presenting cells (APCs). |
format |
Report |
author |
Zhang, Xu-Jie Zhang, Xiang-Yang Wang, Peng Zhang, Yong-An |
author_facet |
Zhang, Xu-Jie Zhang, Xiang-Yang Wang, Peng Zhang, Yong-An |
author_sort |
Zhang, Xu-Jie |
title |
Identification of another primordial CD80/86 molecule in rainbow trout: Insights into the origin and evolution of CD80 and CD86 in vertebrates |
title_short |
Identification of another primordial CD80/86 molecule in rainbow trout: Insights into the origin and evolution of CD80 and CD86 in vertebrates |
title_full |
Identification of another primordial CD80/86 molecule in rainbow trout: Insights into the origin and evolution of CD80 and CD86 in vertebrates |
title_fullStr |
Identification of another primordial CD80/86 molecule in rainbow trout: Insights into the origin and evolution of CD80 and CD86 in vertebrates |
title_full_unstemmed |
Identification of another primordial CD80/86 molecule in rainbow trout: Insights into the origin and evolution of CD80 and CD86 in vertebrates |
title_sort |
identification of another primordial cd80/86 molecule in rainbow trout: insights into the origin and evolution of cd80 and cd86 in vertebrates |
publisher |
ELSEVIER SCI LTD |
publishDate |
2018 |
url |
http://ir.ihb.ac.cn/handle/342005/29348 http://ir.ihb.ac.cn/handle/342005/29349 https://doi.org/10.1016/j.dci.2018.08.007 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_relation |
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY http://ir.ihb.ac.cn/handle/342005/29348 http://ir.ihb.ac.cn/handle/342005/29349 doi:10.1016/j.dci.2018.08.007 |
op_doi |
https://doi.org/10.1016/j.dci.2018.08.007 |
container_title |
Developmental & Comparative Immunology |
container_volume |
89 |
container_start_page |
73 |
op_container_end_page |
82 |
_version_ |
1766363212794560512 |