Increase of myocardial performance by Rhodiola-ethanol extract in diabetic rats
Ethno pharmacological relevance: Rhodiola rosea (also known as golden root or roseroot) is a perennial plant of the Crassulaceae family that grows in the Arctic and in the mountainous regions of Europe, Asia, and North America. The rhizome and roots of this plant have been long used as traditional m...
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ftchengkunguniv:oai:ir.lib.ncku.edu.tw:987654321/133979 2023-05-15T15:18:37+02:00 Increase of myocardial performance by Rhodiola-ethanol extract in diabetic rats Cheng, YZ (Cheng, Yung-Ze) Chen, LJ (Chen, Li-Jen) Lee, WJ (Lee, Wei-Jing) Chen, MF (Chen, Mei-Fen) Lin, HJ (Lin, Hung Jung) Cheng, JT (Cheng, Juei-Tang) Department of Pharmacology 2012-11 https://doi.org/10.1016/j.jep.2012.08.029 http://ir.lib.ncku.edu.tw/handle/987654321/133979 http://ir.lib.ncku.edu.tw/bitstream/987654321/133979/-1/index.html Eng en_US eng Elsevier JOURNAL OF ETHNOPHARMACOLOGY, Vol. 144, No. 2, pp. 234-239 Rhodiola-ethanol extract Cardiac output PPAR-delta STZ-diabetic rats article 2012 ftchengkunguniv https://doi.org/10.1016/j.jep.2012.08.029 2016-05-22T07:59:08Z Ethno pharmacological relevance: Rhodiola rosea (also known as golden root or roseroot) is a perennial plant of the Crassulaceae family that grows in the Arctic and in the mountainous regions of Europe, Asia, and North America. The rhizome and roots of this plant have been long used as traditional medicine in Eastern Europe and Asia for enhancing physical and mental performance. Aim of the study: The present study is designed to investigate the cardiac action of Rhodiola-ethanol extract in streptozotocin-induced diabetic rats (STZ-diabetic rats) with heart failure. Materials and methods: Diabetes was induced in Wistar rats by injection of streptozotocin. We measured the changes of body weight, water intake, and food intake in three groups of age-matched rats; the normal control received vehicle, STZ-diabetic rat received Rhodiola-ethanol extract or vehicle. Cardiac output, heart rate, blood pressure, and hemodynamic dP/dt in addition to plasma insulin and glucose level were also determined. The mRNA and protein levels of PPAR delta were measured using real-time PCR and Western blotting, respectively. Results: Food intake, water intake and blood glucose were raised in STZ-diabetic rats showing lower body weight and plasma insulin, as compared with the control. Also, cardiac output, heart rate, blood pressure and hemodynamic dP/dt were markedly reduced in STZ-diabetic rats indicating the heart failure physiologically. After a 21-day treatment with Rhodiola-ethanol extract, cardiac output was raised in STZ-rats while the diabetic parameters were not modified. The PPAR delta expression of both mRNA and protein was markedly elevated in the heart of STZ-rats receiving treatment with Rhodiola-ethanol extract. Also, the increased phosphorylation level of cardiac troponin-I was restored by this treatment with Rhodiola-ethanol extract. Otherwise, increase of cardiac output by Rhodiola-ethanol extract was blocked by antagonist of PPAR delta in STZ-diabetic rats. Conclusions: Our results suggest that ethanol extract of Rhodiola has an ability to increase the cardiac output in STZ-diabetic rats showing heart failure. Also, increase of PPAR-delta is responsible for this action of Rodiola-ethanol extract. Article in Journal/Newspaper Arctic National Cheng Kung University: NCKU Institutional Repository Arctic Journal of Ethnopharmacology 144 2 234 239 |
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National Cheng Kung University: NCKU Institutional Repository |
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ftchengkunguniv |
language |
English |
topic |
Rhodiola-ethanol extract Cardiac output PPAR-delta STZ-diabetic rats |
spellingShingle |
Rhodiola-ethanol extract Cardiac output PPAR-delta STZ-diabetic rats Cheng, YZ (Cheng, Yung-Ze) Chen, LJ (Chen, Li-Jen) Lee, WJ (Lee, Wei-Jing) Chen, MF (Chen, Mei-Fen) Lin, HJ (Lin, Hung Jung) Cheng, JT (Cheng, Juei-Tang) Increase of myocardial performance by Rhodiola-ethanol extract in diabetic rats |
topic_facet |
Rhodiola-ethanol extract Cardiac output PPAR-delta STZ-diabetic rats |
description |
Ethno pharmacological relevance: Rhodiola rosea (also known as golden root or roseroot) is a perennial plant of the Crassulaceae family that grows in the Arctic and in the mountainous regions of Europe, Asia, and North America. The rhizome and roots of this plant have been long used as traditional medicine in Eastern Europe and Asia for enhancing physical and mental performance. Aim of the study: The present study is designed to investigate the cardiac action of Rhodiola-ethanol extract in streptozotocin-induced diabetic rats (STZ-diabetic rats) with heart failure. Materials and methods: Diabetes was induced in Wistar rats by injection of streptozotocin. We measured the changes of body weight, water intake, and food intake in three groups of age-matched rats; the normal control received vehicle, STZ-diabetic rat received Rhodiola-ethanol extract or vehicle. Cardiac output, heart rate, blood pressure, and hemodynamic dP/dt in addition to plasma insulin and glucose level were also determined. The mRNA and protein levels of PPAR delta were measured using real-time PCR and Western blotting, respectively. Results: Food intake, water intake and blood glucose were raised in STZ-diabetic rats showing lower body weight and plasma insulin, as compared with the control. Also, cardiac output, heart rate, blood pressure and hemodynamic dP/dt were markedly reduced in STZ-diabetic rats indicating the heart failure physiologically. After a 21-day treatment with Rhodiola-ethanol extract, cardiac output was raised in STZ-rats while the diabetic parameters were not modified. The PPAR delta expression of both mRNA and protein was markedly elevated in the heart of STZ-rats receiving treatment with Rhodiola-ethanol extract. Also, the increased phosphorylation level of cardiac troponin-I was restored by this treatment with Rhodiola-ethanol extract. Otherwise, increase of cardiac output by Rhodiola-ethanol extract was blocked by antagonist of PPAR delta in STZ-diabetic rats. Conclusions: Our results suggest that ethanol extract of Rhodiola has an ability to increase the cardiac output in STZ-diabetic rats showing heart failure. Also, increase of PPAR-delta is responsible for this action of Rodiola-ethanol extract. |
author2 |
Department of Pharmacology |
format |
Article in Journal/Newspaper |
author |
Cheng, YZ (Cheng, Yung-Ze) Chen, LJ (Chen, Li-Jen) Lee, WJ (Lee, Wei-Jing) Chen, MF (Chen, Mei-Fen) Lin, HJ (Lin, Hung Jung) Cheng, JT (Cheng, Juei-Tang) |
author_facet |
Cheng, YZ (Cheng, Yung-Ze) Chen, LJ (Chen, Li-Jen) Lee, WJ (Lee, Wei-Jing) Chen, MF (Chen, Mei-Fen) Lin, HJ (Lin, Hung Jung) Cheng, JT (Cheng, Juei-Tang) |
author_sort |
Cheng, YZ (Cheng, Yung-Ze) |
title |
Increase of myocardial performance by Rhodiola-ethanol extract in diabetic rats |
title_short |
Increase of myocardial performance by Rhodiola-ethanol extract in diabetic rats |
title_full |
Increase of myocardial performance by Rhodiola-ethanol extract in diabetic rats |
title_fullStr |
Increase of myocardial performance by Rhodiola-ethanol extract in diabetic rats |
title_full_unstemmed |
Increase of myocardial performance by Rhodiola-ethanol extract in diabetic rats |
title_sort |
increase of myocardial performance by rhodiola-ethanol extract in diabetic rats |
publisher |
Elsevier |
publishDate |
2012 |
url |
https://doi.org/10.1016/j.jep.2012.08.029 http://ir.lib.ncku.edu.tw/handle/987654321/133979 http://ir.lib.ncku.edu.tw/bitstream/987654321/133979/-1/index.html |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_relation |
JOURNAL OF ETHNOPHARMACOLOGY, Vol. 144, No. 2, pp. 234-239 |
op_doi |
https://doi.org/10.1016/j.jep.2012.08.029 |
container_title |
Journal of Ethnopharmacology |
container_volume |
144 |
container_issue |
2 |
container_start_page |
234 |
op_container_end_page |
239 |
_version_ |
1766348814726201344 |