Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE): a prospective birth cohort in northern Sweden
© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. INTRODUCTION: Prenatal and neonatal environmental factors, such as nutrition, microbes and toxicants, may affect health throughout life. Many diseases, such a...
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ftchalmersuniv:oai:research.chalmers.se:505752 2023-05-15T17:45:08+02:00 Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE): a prospective birth cohort in northern Sweden Barman, Malin Murray, Fiona Bernardi, Angelina I. Broberg, Karin Bölte, Sven Hesselmar, Bill Jacobsson, Bo Jonsson, Karin Kippler, Maria Rabe, Hardis Ross, Alastair Sjoberg, F. Strömberg, Nicklas Vahter, Marie Wold, Agnes E Sandberg, Ann-Sofie Sandin, Anna 2018 text https://doi.org/10.1136/bmjopen-2018-022013 https://research.chalmers.se/en/publication/505752 unknown http://dx.doi.org/10.1136/bmjopen-2018-022013 https://research.chalmers.se/en/publication/505752 Pediatrics Environmental Health and Occupational Health Public Health Global Health Social Medicine and Epidemiology allergy microbiology toxicants nutrition birth cohort immunology 2018 ftchalmersuniv https://doi.org/10.1136/bmjopen-2018-022013 2022-12-11T07:15:12Z © Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. INTRODUCTION: Prenatal and neonatal environmental factors, such as nutrition, microbes and toxicants, may affect health throughout life. Many diseases, such as allergy and impaired child development, may be programmed already in utero or during early infancy. Birth cohorts are important tools to study associations between early life exposure and disease risk. Here, we describe the study protocol of the prospective birth cohort, 'Nutritional impact on Immunological maturation during Childhood in relation to the Environment' (NICE). The primary aim of the NICE cohort is to clarify the effect of key environmental exposures-diet, microbes and environmental toxicants-during pregnancy and early childhood, on the maturation of the infant's immune system, including initiation of sensitisation and allergy as well as some secondary outcomes: infant growth, obesity, neurological development and oral health.METHODS AND ANALYSIS: The NICE cohort will recruit about 650 families during mid-pregnancy. The principal inclusion criterion will be planned birth at the Sunderby Hospital in the north of Sweden, during 2015-2018. Questionnaires data and biological samples will be collected at 10 time-points, from pregnancy until the children reach 4 years of age. Samples will be collected primarily from mothers and children, and from fathers. Biological samples include blood, urine, placenta, breast milk, meconium, faeces, saliva and hair. Information regarding allergic heredity, diet, socioeconomic status, lifestyle including smoking, siblings, pet ownership, etc will be collected using questionnaires. Sensitisation to common allergens will be assessed by skin prick testing and allergic disease will be diagnosed by a paediatrician at 1 and 4 years of age. At 4 years of age, the children will also be examined regarding growth, neurobehavioural and neurophysiological status and oral health.ETHICS ... Other/Unknown Material Northern Sweden Chalmers University of Technology: Chalmers research Sunderby Hospital ENVELOPE(21.931,21.931,65.672,65.672) BMJ Open 8 10 e022013 |
institution |
Open Polar |
collection |
Chalmers University of Technology: Chalmers research |
op_collection_id |
ftchalmersuniv |
language |
unknown |
topic |
Pediatrics Environmental Health and Occupational Health Public Health Global Health Social Medicine and Epidemiology allergy microbiology toxicants nutrition birth cohort immunology |
spellingShingle |
Pediatrics Environmental Health and Occupational Health Public Health Global Health Social Medicine and Epidemiology allergy microbiology toxicants nutrition birth cohort immunology Barman, Malin Murray, Fiona Bernardi, Angelina I. Broberg, Karin Bölte, Sven Hesselmar, Bill Jacobsson, Bo Jonsson, Karin Kippler, Maria Rabe, Hardis Ross, Alastair Sjoberg, F. Strömberg, Nicklas Vahter, Marie Wold, Agnes E Sandberg, Ann-Sofie Sandin, Anna Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE): a prospective birth cohort in northern Sweden |
topic_facet |
Pediatrics Environmental Health and Occupational Health Public Health Global Health Social Medicine and Epidemiology allergy microbiology toxicants nutrition birth cohort immunology |
description |
© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. INTRODUCTION: Prenatal and neonatal environmental factors, such as nutrition, microbes and toxicants, may affect health throughout life. Many diseases, such as allergy and impaired child development, may be programmed already in utero or during early infancy. Birth cohorts are important tools to study associations between early life exposure and disease risk. Here, we describe the study protocol of the prospective birth cohort, 'Nutritional impact on Immunological maturation during Childhood in relation to the Environment' (NICE). The primary aim of the NICE cohort is to clarify the effect of key environmental exposures-diet, microbes and environmental toxicants-during pregnancy and early childhood, on the maturation of the infant's immune system, including initiation of sensitisation and allergy as well as some secondary outcomes: infant growth, obesity, neurological development and oral health.METHODS AND ANALYSIS: The NICE cohort will recruit about 650 families during mid-pregnancy. The principal inclusion criterion will be planned birth at the Sunderby Hospital in the north of Sweden, during 2015-2018. Questionnaires data and biological samples will be collected at 10 time-points, from pregnancy until the children reach 4 years of age. Samples will be collected primarily from mothers and children, and from fathers. Biological samples include blood, urine, placenta, breast milk, meconium, faeces, saliva and hair. Information regarding allergic heredity, diet, socioeconomic status, lifestyle including smoking, siblings, pet ownership, etc will be collected using questionnaires. Sensitisation to common allergens will be assessed by skin prick testing and allergic disease will be diagnosed by a paediatrician at 1 and 4 years of age. At 4 years of age, the children will also be examined regarding growth, neurobehavioural and neurophysiological status and oral health.ETHICS ... |
author |
Barman, Malin Murray, Fiona Bernardi, Angelina I. Broberg, Karin Bölte, Sven Hesselmar, Bill Jacobsson, Bo Jonsson, Karin Kippler, Maria Rabe, Hardis Ross, Alastair Sjoberg, F. Strömberg, Nicklas Vahter, Marie Wold, Agnes E Sandberg, Ann-Sofie Sandin, Anna |
author_facet |
Barman, Malin Murray, Fiona Bernardi, Angelina I. Broberg, Karin Bölte, Sven Hesselmar, Bill Jacobsson, Bo Jonsson, Karin Kippler, Maria Rabe, Hardis Ross, Alastair Sjoberg, F. Strömberg, Nicklas Vahter, Marie Wold, Agnes E Sandberg, Ann-Sofie Sandin, Anna |
author_sort |
Barman, Malin |
title |
Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE): a prospective birth cohort in northern Sweden |
title_short |
Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE): a prospective birth cohort in northern Sweden |
title_full |
Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE): a prospective birth cohort in northern Sweden |
title_fullStr |
Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE): a prospective birth cohort in northern Sweden |
title_full_unstemmed |
Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE): a prospective birth cohort in northern Sweden |
title_sort |
nutritional impact on immunological maturation during childhood in relation to the environment (nice): a prospective birth cohort in northern sweden |
publishDate |
2018 |
url |
https://doi.org/10.1136/bmjopen-2018-022013 https://research.chalmers.se/en/publication/505752 |
long_lat |
ENVELOPE(21.931,21.931,65.672,65.672) |
geographic |
Sunderby Hospital |
geographic_facet |
Sunderby Hospital |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
http://dx.doi.org/10.1136/bmjopen-2018-022013 https://research.chalmers.se/en/publication/505752 |
op_doi |
https://doi.org/10.1136/bmjopen-2018-022013 |
container_title |
BMJ Open |
container_volume |
8 |
container_issue |
10 |
container_start_page |
e022013 |
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1766147910632734720 |