The Carotid Artery Plaque Size and Echogenicity are Related to Different Cardiovascular Risk Factors in the Elderly
Carotid plaques can be characterised by ultrasound by size and echogenicity. Both size and echogenicity are predictors of cardiovascular events. The aim of this study was to examine whether traditional risk factors and markers of inflammation and oxidation were associated with plaque size and echoge...
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ftchalmersuniv:oai:research.chalmers.se:114165 2023-05-15T18:33:53+02:00 The Carotid Artery Plaque Size and Echogenicity are Related to Different Cardiovascular Risk Factors in the Elderly Andersson, J. Sundstrom, J. Kurland, L. Gustavsson, Tomas Hulthe, Johannes Elmgren, A. Zilmer, K. Zilmer, M. Lind, L. 2009 text https://doi.org/10.1007/s11745-009-3281-y https://research.chalmers.se/en/publication/114165 unknown http://dx.doi.org/10.1007/s11745-009-3281-y https://research.chalmers.se/en/publication/114165 Cardiac and Cardiovascular Systems Carotid artery Atherosclerosis men coronary-heart-disease density-lipoprotein cholesterol independent predictor prevalence tromso seniors pivus Oxidation Plaque general-population Ultrasound Risk factor count leukocyte uppsala Lipids 2009 ftchalmersuniv https://doi.org/10.1007/s11745-009-3281-y 2022-12-11T07:07:02Z Carotid plaques can be characterised by ultrasound by size and echogenicity. Both size and echogenicity are predictors of cardiovascular events. The aim of this study was to examine whether traditional risk factors and markers of inflammation and oxidation were associated with plaque size and echogenicity. Computerised analysis of carotid plaque size and echogenicity (grey scale median, GSM) were performed by ultrasound in a population-based health survey in 1,016 subjects aged 70 years (PIVUS study). Information on cardiovascular risk factors was collected, together with markers of inflammation and oxidation. Increased Framingham risk score, systolic blood pressure, higher BMI and decreased HDL, lower glutathione levels were related to echolucent plaques. Previous or present smoking was common with significantly more pack-years related to the echorich plaques. Plaque size was associated with increased Framingham risk score, systolic blood pressure, blood glucose levels, smoking, ApoB/A1 ratio, OxLDL, TNF alpha, HOMA insulin resistance, leucocyte count, decreased BCD-LDL and low levels of l-selectin. Low HDL, increased BMI and decreased glutathione levels were associated with the echolucency of carotid plaques, implying metabolic factors to play a role for plaque composition. Markers of inflammation were related to plaque size alone, implying inflammation to be predominantly associated with the amount of atherosclerosis. These results suggest that plaque size and echogenicity are influenced by different risk factors. Other/Unknown Material Tromso Tromso Chalmers University of Technology: Chalmers research Tromso ENVELOPE(16.546,16.546,68.801,68.801) Lipids 44 5 397 403 |
institution |
Open Polar |
collection |
Chalmers University of Technology: Chalmers research |
op_collection_id |
ftchalmersuniv |
language |
unknown |
topic |
Cardiac and Cardiovascular Systems Carotid artery Atherosclerosis men coronary-heart-disease density-lipoprotein cholesterol independent predictor prevalence tromso seniors pivus Oxidation Plaque general-population Ultrasound Risk factor count leukocyte uppsala Lipids |
spellingShingle |
Cardiac and Cardiovascular Systems Carotid artery Atherosclerosis men coronary-heart-disease density-lipoprotein cholesterol independent predictor prevalence tromso seniors pivus Oxidation Plaque general-population Ultrasound Risk factor count leukocyte uppsala Lipids Andersson, J. Sundstrom, J. Kurland, L. Gustavsson, Tomas Hulthe, Johannes Elmgren, A. Zilmer, K. Zilmer, M. Lind, L. The Carotid Artery Plaque Size and Echogenicity are Related to Different Cardiovascular Risk Factors in the Elderly |
topic_facet |
Cardiac and Cardiovascular Systems Carotid artery Atherosclerosis men coronary-heart-disease density-lipoprotein cholesterol independent predictor prevalence tromso seniors pivus Oxidation Plaque general-population Ultrasound Risk factor count leukocyte uppsala Lipids |
description |
Carotid plaques can be characterised by ultrasound by size and echogenicity. Both size and echogenicity are predictors of cardiovascular events. The aim of this study was to examine whether traditional risk factors and markers of inflammation and oxidation were associated with plaque size and echogenicity. Computerised analysis of carotid plaque size and echogenicity (grey scale median, GSM) were performed by ultrasound in a population-based health survey in 1,016 subjects aged 70 years (PIVUS study). Information on cardiovascular risk factors was collected, together with markers of inflammation and oxidation. Increased Framingham risk score, systolic blood pressure, higher BMI and decreased HDL, lower glutathione levels were related to echolucent plaques. Previous or present smoking was common with significantly more pack-years related to the echorich plaques. Plaque size was associated with increased Framingham risk score, systolic blood pressure, blood glucose levels, smoking, ApoB/A1 ratio, OxLDL, TNF alpha, HOMA insulin resistance, leucocyte count, decreased BCD-LDL and low levels of l-selectin. Low HDL, increased BMI and decreased glutathione levels were associated with the echolucency of carotid plaques, implying metabolic factors to play a role for plaque composition. Markers of inflammation were related to plaque size alone, implying inflammation to be predominantly associated with the amount of atherosclerosis. These results suggest that plaque size and echogenicity are influenced by different risk factors. |
author |
Andersson, J. Sundstrom, J. Kurland, L. Gustavsson, Tomas Hulthe, Johannes Elmgren, A. Zilmer, K. Zilmer, M. Lind, L. |
author_facet |
Andersson, J. Sundstrom, J. Kurland, L. Gustavsson, Tomas Hulthe, Johannes Elmgren, A. Zilmer, K. Zilmer, M. Lind, L. |
author_sort |
Andersson, J. |
title |
The Carotid Artery Plaque Size and Echogenicity are Related to Different Cardiovascular Risk Factors in the Elderly |
title_short |
The Carotid Artery Plaque Size and Echogenicity are Related to Different Cardiovascular Risk Factors in the Elderly |
title_full |
The Carotid Artery Plaque Size and Echogenicity are Related to Different Cardiovascular Risk Factors in the Elderly |
title_fullStr |
The Carotid Artery Plaque Size and Echogenicity are Related to Different Cardiovascular Risk Factors in the Elderly |
title_full_unstemmed |
The Carotid Artery Plaque Size and Echogenicity are Related to Different Cardiovascular Risk Factors in the Elderly |
title_sort |
carotid artery plaque size and echogenicity are related to different cardiovascular risk factors in the elderly |
publishDate |
2009 |
url |
https://doi.org/10.1007/s11745-009-3281-y https://research.chalmers.se/en/publication/114165 |
long_lat |
ENVELOPE(16.546,16.546,68.801,68.801) |
geographic |
Tromso |
geographic_facet |
Tromso |
genre |
Tromso Tromso |
genre_facet |
Tromso Tromso |
op_relation |
http://dx.doi.org/10.1007/s11745-009-3281-y https://research.chalmers.se/en/publication/114165 |
op_doi |
https://doi.org/10.1007/s11745-009-3281-y |
container_title |
Lipids |
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44 |
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5 |
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397 |
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403 |
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1766218522245988352 |