Cobaloxime-based artificial hydrogenases.
International audience Cobaloximes are popular H2 evolution molecular catalysts but have so far mainly been studied in nonaqueous conditions. We show here that they are also valuable for the design of artificial hydrogenases for application in neutral aqueous solutions and report on the preparation...
Published in: | Inorganic Chemistry |
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Online Access: | https://hal.science/hal-01069152 https://hal.science/hal-01069152/document https://hal.science/hal-01069152/file/Article%20Marine%2004072014.pdf https://doi.org/10.1021/ic501014c |
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ftceafr:oai:HAL:hal-01069152v1 2024-09-15T18:37:34+00:00 Cobaloxime-based artificial hydrogenases. Bacchi, Marine Berggren, Gustav Niklas, Jens Veinberg, Elias Mara, Michael W. Shelby, Megan L. Poluektov, Oleg G. Chen, Lin X. Tiede, David M Cavazza, Christine Field, Martin J Fontecave, Marc Artero, Vincent Laboratoire de Chimie et Biologie des Métaux (LCBM - UMR 5249) Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes 2016-2019 (UGA 2016-2019 )-Institut de Recherche Interdisciplinaire de Grenoble (IRIG) Direction de Recherche Fondamentale (CEA) (DRF (CEA)) Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)) Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA) Argonne National Laboratory Lemont (ANL) Institut de biologie structurale (IBS - UMR 5075 ) Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes 2016-2019 (UGA 2016-2019 )-Institut de Recherche Interdisciplinaire de Grenoble (IRIG) Northwestern University Evanston Collège de France - Chaire Chimie des processus biologiques Laboratoire de Chimie des Processus Biologiques (LCPB) Collège de France (CdF (institution))-Institut de Chimie - CNRS Chimie (INC-CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie - CNRS Chimie (INC-CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) ANR-11-LABX-0003,ARCANE,Grenoble, une chimie bio-motivée(2011) 2014-08-04 https://hal.science/hal-01069152 https://hal.science/hal-01069152/document https://hal.science/hal-01069152/file/Article%20Marine%2004072014.pdf https://doi.org/10.1021/ic501014c en eng HAL CCSD American Chemical Society info:eu-repo/semantics/altIdentifier/doi/10.1021/ic501014c info:eu-repo/semantics/altIdentifier/pmid/25029381 hal-01069152 https://hal.science/hal-01069152 https://hal.science/hal-01069152/document https://hal.science/hal-01069152/file/Article%20Marine%2004072014.pdf doi:10.1021/ic501014c PUBMED: 25029381 info:eu-repo/semantics/OpenAccess ISSN: 0020-1669 EISSN: 1520-510X Inorganic Chemistry https://hal.science/hal-01069152 Inorganic Chemistry, 2014, 53 (15), pp.8071-8082. ⟨10.1021/ic501014c⟩ [CHIM.INOR]Chemical Sciences/Inorganic chemistry info:eu-repo/semantics/article Journal articles 2014 ftceafr https://doi.org/10.1021/ic501014c 2024-07-22T13:26:37Z International audience Cobaloximes are popular H2 evolution molecular catalysts but have so far mainly been studied in nonaqueous conditions. We show here that they are also valuable for the design of artificial hydrogenases for application in neutral aqueous solutions and report on the preparation of two well-defined biohybrid species via the binding of two cobaloxime moieties, {Co(dmgH)2} and {Co(dmgBF2)2} (dmgH2 = dimethylglyoxime), to apo Sperm-whale myoglobin (SwMb). All spectroscopic data confirm that the cobaloxime moieties are inserted within the binding pocket of the SwMb protein and are coordinated to a histidine residue in the axial position of the cobalt complex, resulting in thermodynamically stable complexes. Quantum chemical/molecular mechanical docking calculations indicated a coordination preference for His93 over the other histidine residue (His64) present in the vicinity. Interestingly, the redox activity of the cobalt centers is retained in both biohybrids, which provides them with the catalytic activity for H2 evolution in near-neutral aqueous conditions. Article in Journal/Newspaper Sperm whale HAL-CEA (Commissariat à l'énergie atomique et aux énergies alternatives) Inorganic Chemistry 53 15 8071 8082 |
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Open Polar |
collection |
HAL-CEA (Commissariat à l'énergie atomique et aux énergies alternatives) |
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ftceafr |
language |
English |
topic |
[CHIM.INOR]Chemical Sciences/Inorganic chemistry |
spellingShingle |
[CHIM.INOR]Chemical Sciences/Inorganic chemistry Bacchi, Marine Berggren, Gustav Niklas, Jens Veinberg, Elias Mara, Michael W. Shelby, Megan L. Poluektov, Oleg G. Chen, Lin X. Tiede, David M Cavazza, Christine Field, Martin J Fontecave, Marc Artero, Vincent Cobaloxime-based artificial hydrogenases. |
topic_facet |
[CHIM.INOR]Chemical Sciences/Inorganic chemistry |
description |
International audience Cobaloximes are popular H2 evolution molecular catalysts but have so far mainly been studied in nonaqueous conditions. We show here that they are also valuable for the design of artificial hydrogenases for application in neutral aqueous solutions and report on the preparation of two well-defined biohybrid species via the binding of two cobaloxime moieties, {Co(dmgH)2} and {Co(dmgBF2)2} (dmgH2 = dimethylglyoxime), to apo Sperm-whale myoglobin (SwMb). All spectroscopic data confirm that the cobaloxime moieties are inserted within the binding pocket of the SwMb protein and are coordinated to a histidine residue in the axial position of the cobalt complex, resulting in thermodynamically stable complexes. Quantum chemical/molecular mechanical docking calculations indicated a coordination preference for His93 over the other histidine residue (His64) present in the vicinity. Interestingly, the redox activity of the cobalt centers is retained in both biohybrids, which provides them with the catalytic activity for H2 evolution in near-neutral aqueous conditions. |
author2 |
Laboratoire de Chimie et Biologie des Métaux (LCBM - UMR 5249) Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes 2016-2019 (UGA 2016-2019 )-Institut de Recherche Interdisciplinaire de Grenoble (IRIG) Direction de Recherche Fondamentale (CEA) (DRF (CEA)) Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)) Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA) Argonne National Laboratory Lemont (ANL) Institut de biologie structurale (IBS - UMR 5075 ) Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes 2016-2019 (UGA 2016-2019 )-Institut de Recherche Interdisciplinaire de Grenoble (IRIG) Northwestern University Evanston Collège de France - Chaire Chimie des processus biologiques Laboratoire de Chimie des Processus Biologiques (LCPB) Collège de France (CdF (institution))-Institut de Chimie - CNRS Chimie (INC-CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie - CNRS Chimie (INC-CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) ANR-11-LABX-0003,ARCANE,Grenoble, une chimie bio-motivée(2011) |
format |
Article in Journal/Newspaper |
author |
Bacchi, Marine Berggren, Gustav Niklas, Jens Veinberg, Elias Mara, Michael W. Shelby, Megan L. Poluektov, Oleg G. Chen, Lin X. Tiede, David M Cavazza, Christine Field, Martin J Fontecave, Marc Artero, Vincent |
author_facet |
Bacchi, Marine Berggren, Gustav Niklas, Jens Veinberg, Elias Mara, Michael W. Shelby, Megan L. Poluektov, Oleg G. Chen, Lin X. Tiede, David M Cavazza, Christine Field, Martin J Fontecave, Marc Artero, Vincent |
author_sort |
Bacchi, Marine |
title |
Cobaloxime-based artificial hydrogenases. |
title_short |
Cobaloxime-based artificial hydrogenases. |
title_full |
Cobaloxime-based artificial hydrogenases. |
title_fullStr |
Cobaloxime-based artificial hydrogenases. |
title_full_unstemmed |
Cobaloxime-based artificial hydrogenases. |
title_sort |
cobaloxime-based artificial hydrogenases. |
publisher |
HAL CCSD |
publishDate |
2014 |
url |
https://hal.science/hal-01069152 https://hal.science/hal-01069152/document https://hal.science/hal-01069152/file/Article%20Marine%2004072014.pdf https://doi.org/10.1021/ic501014c |
genre |
Sperm whale |
genre_facet |
Sperm whale |
op_source |
ISSN: 0020-1669 EISSN: 1520-510X Inorganic Chemistry https://hal.science/hal-01069152 Inorganic Chemistry, 2014, 53 (15), pp.8071-8082. ⟨10.1021/ic501014c⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1021/ic501014c info:eu-repo/semantics/altIdentifier/pmid/25029381 hal-01069152 https://hal.science/hal-01069152 https://hal.science/hal-01069152/document https://hal.science/hal-01069152/file/Article%20Marine%2004072014.pdf doi:10.1021/ic501014c PUBMED: 25029381 |
op_rights |
info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.1021/ic501014c |
container_title |
Inorganic Chemistry |
container_volume |
53 |
container_issue |
15 |
container_start_page |
8071 |
op_container_end_page |
8082 |
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1810481934489354240 |