Non-negative Matrix Factorization under sparsity constraints to unmix in vivo spectrally resolved acquisitions
International audience Fluorescence imaging in diffusive media is an emerging imaging modality for medical applications which uses injected fluorescent markers (several ones may be simultaneously injected) that bind to specific targets, as tumors. The region of interest is illuminated with near infr...
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ftceafr:oai:HAL:hal-00625417v1 2024-06-09T07:47:09+00:00 Non-negative Matrix Factorization under sparsity constraints to unmix in vivo spectrally resolved acquisitions Montcuquet, Anne-Sophie Herve, Lionel Navarro, Fabrice Dinten, Jean-Marc Mars, Jerome, I. GIPSA - Signal Images Physique (GIPSA-SIGMAPHY) Département Images et Signal (GIPSA-DIS) Grenoble Images Parole Signal Automatique (GIPSA-lab) Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Grenoble Images Parole Signal Automatique (GIPSA-lab) Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS) Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI) Direction de Recherche Technologique (CEA) (DRT (CEA)) Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA) Reykjavik, Iceland 2010-06-14 https://hal.science/hal-00625417 https://hal.science/hal-00625417/document https://hal.science/hal-00625417/file/whispers2010_submission_55.pdf en eng HAL CCSD hal-00625417 https://hal.science/hal-00625417 https://hal.science/hal-00625417/document https://hal.science/hal-00625417/file/whispers2010_submission_55.pdf info:eu-repo/semantics/OpenAccess WHISPERS 2010 - 2nd Workshop on Hyperspectral Image and Signal Processing: Evolution in Remote Sensing https://hal.science/hal-00625417 WHISPERS 2010 - 2nd Workshop on Hyperspectral Image and Signal Processing: Evolution in Remote Sensing, Jun 2010, Reykjavik, Iceland. pp.30 [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing info:eu-repo/semantics/conferenceObject Conference papers 2010 ftceafr 2024-05-16T12:49:14Z International audience Fluorescence imaging in diffusive media is an emerging imaging modality for medical applications which uses injected fluorescent markers (several ones may be simultaneously injected) that bind to specific targets, as tumors. The region of interest is illuminated with near infrared light and the emitted back fluorescence is analyzed to localize the fluorescence sources. To investigate thick medium, as the fluorescence signal decreases with the light travel distance, any disturbing signal, such as biological tissues intrinsic fluorescence - called autofluorescence -, is a limiting factor. To remove autofluorescence and isolate each specific fluorescent signal from the others, a spectroscopic approach, based on Non-negative Matrix Factorization, is explored. We ran an NMF algorithm with sparsity constraints on experimental data, and successfully obtained separated in vivo fluorescence spectra. Conference Object Iceland HAL-CEA (Commissariat à l'énergie atomique et aux énergies alternatives) |
institution |
Open Polar |
collection |
HAL-CEA (Commissariat à l'énergie atomique et aux énergies alternatives) |
op_collection_id |
ftceafr |
language |
English |
topic |
[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing |
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[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing Montcuquet, Anne-Sophie Herve, Lionel Navarro, Fabrice Dinten, Jean-Marc Mars, Jerome, I. Non-negative Matrix Factorization under sparsity constraints to unmix in vivo spectrally resolved acquisitions |
topic_facet |
[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing |
description |
International audience Fluorescence imaging in diffusive media is an emerging imaging modality for medical applications which uses injected fluorescent markers (several ones may be simultaneously injected) that bind to specific targets, as tumors. The region of interest is illuminated with near infrared light and the emitted back fluorescence is analyzed to localize the fluorescence sources. To investigate thick medium, as the fluorescence signal decreases with the light travel distance, any disturbing signal, such as biological tissues intrinsic fluorescence - called autofluorescence -, is a limiting factor. To remove autofluorescence and isolate each specific fluorescent signal from the others, a spectroscopic approach, based on Non-negative Matrix Factorization, is explored. We ran an NMF algorithm with sparsity constraints on experimental data, and successfully obtained separated in vivo fluorescence spectra. |
author2 |
GIPSA - Signal Images Physique (GIPSA-SIGMAPHY) Département Images et Signal (GIPSA-DIS) Grenoble Images Parole Signal Automatique (GIPSA-lab) Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Grenoble Images Parole Signal Automatique (GIPSA-lab) Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS) Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI) Direction de Recherche Technologique (CEA) (DRT (CEA)) Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA) |
format |
Conference Object |
author |
Montcuquet, Anne-Sophie Herve, Lionel Navarro, Fabrice Dinten, Jean-Marc Mars, Jerome, I. |
author_facet |
Montcuquet, Anne-Sophie Herve, Lionel Navarro, Fabrice Dinten, Jean-Marc Mars, Jerome, I. |
author_sort |
Montcuquet, Anne-Sophie |
title |
Non-negative Matrix Factorization under sparsity constraints to unmix in vivo spectrally resolved acquisitions |
title_short |
Non-negative Matrix Factorization under sparsity constraints to unmix in vivo spectrally resolved acquisitions |
title_full |
Non-negative Matrix Factorization under sparsity constraints to unmix in vivo spectrally resolved acquisitions |
title_fullStr |
Non-negative Matrix Factorization under sparsity constraints to unmix in vivo spectrally resolved acquisitions |
title_full_unstemmed |
Non-negative Matrix Factorization under sparsity constraints to unmix in vivo spectrally resolved acquisitions |
title_sort |
non-negative matrix factorization under sparsity constraints to unmix in vivo spectrally resolved acquisitions |
publisher |
HAL CCSD |
publishDate |
2010 |
url |
https://hal.science/hal-00625417 https://hal.science/hal-00625417/document https://hal.science/hal-00625417/file/whispers2010_submission_55.pdf |
op_coverage |
Reykjavik, Iceland |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
WHISPERS 2010 - 2nd Workshop on Hyperspectral Image and Signal Processing: Evolution in Remote Sensing https://hal.science/hal-00625417 WHISPERS 2010 - 2nd Workshop on Hyperspectral Image and Signal Processing: Evolution in Remote Sensing, Jun 2010, Reykjavik, Iceland. pp.30 |
op_relation |
hal-00625417 https://hal.science/hal-00625417 https://hal.science/hal-00625417/document https://hal.science/hal-00625417/file/whispers2010_submission_55.pdf |
op_rights |
info:eu-repo/semantics/OpenAccess |
_version_ |
1801378079886540800 |