Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids.
N-3 fatty acids are associated with favorable, and obesity with unfavorable, concentrations of chronic disease risk biomarkers.We examined whether high eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid intakes, measured as percentages of total red blood cell (RBC) fatty acids, modify association...
Published in: | European Journal of Clinical Nutrition |
---|---|
Main Authors: | , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
eScholarship, University of California
2011
|
Subjects: | |
Online Access: | http://www.escholarship.org/uc/item/8nw2s21g |
id |
ftcdlib:qt8nw2s21g |
---|---|
record_format |
openpolar |
spelling |
ftcdlib:qt8nw2s21g 2023-05-15T16:07:27+02:00 Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids. Makhoul, Z Kristal, AR Gulati, R Luick, B Bersamin, A O'Brien, D Hopkins, SE Stephensen, CB Stanhope, KL Havel, PJ Boyer, B 808 - 817 2011-07-01 application/pdf http://www.escholarship.org/uc/item/8nw2s21g english eng eScholarship, University of California qt8nw2s21g http://www.escholarship.org/uc/item/8nw2s21g public Makhoul, Z; Kristal, AR; Gulati, R; Luick, B; Bersamin, A; O'Brien, D; et al.(2011). Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids. European journal of clinical nutrition, 65(7), 808 - 817. doi:10.1038/ejcn.2011.39. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/8nw2s21g Erythrocytes Humans Obesity Fatty Acids Omega-3 Docosahexaenoic Acids Eicosapentaenoic Acid Triglycerides C-Reactive Protein Body Mass Index Models Statistical Risk Factors Cross-Sectional Studies Adolescent Adult Aged 80 and over Middle Aged Inuits Alaska Female Male Dyslipidemias Overweight Young Adult Biomarkers EPA DHA generalized additive models Yup'ik eskimos Nutrition & Dietetics Nutrition and Dietetics Human Movement and Sports Sciences Food Sciences article 2011 ftcdlib https://doi.org/10.1038/ejcn.2011.39 2019-06-28T22:55:19Z N-3 fatty acids are associated with favorable, and obesity with unfavorable, concentrations of chronic disease risk biomarkers.We examined whether high eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid intakes, measured as percentages of total red blood cell (RBC) fatty acids, modify associations of obesity with chronic disease risk biomarkers.In a cross-sectional study of 330 Yup'ik Eskimos, generalized additive models (GAM) and linear and quadratic regression models were used to examine associations of BMI with biomarkers across RBC EPA and DHA categories.Median (5th-95th percentile) RBC EPA and DHA were 2.6% (0.5-5.9%) and 7.3% (3.3-8.9%), respectively. In regression models, associations of BMI with triglycerides, glucose, insulin, C-reactive protein (CRP) and leptin differed significantly by RBC EPA and DHA. The GAM confirmed regression results for triglycerides and CRP: at low RBC EPA and RBC DHA, the predicted increases in triglycerides and CRP concentrations associated with a BMI increase from 25 to 35 were 99.5±45.3 mg/dl (106%) and 137.8±71.0 mg/dl (156%), respectively, for triglycerides and 1.2±0.7 mg/l (61%) and 0.8±1.0 mg/l (35%), respectively, for CRP. At high RBC EPA and RBC DHA, these predicted increases were 13.9±8.1 mg/dl (23%) and 12.0±12.3 mg/dl (18%), respectively, for triglycerides and 0.5±0.5 mg/l (50%) and -0.5±0.6 mg/l (-34%), respectively, for CRP.In this population, high RBC EPA and DHA were associated with attenuated dyslipidemia and low-grade systemic inflammation among overweight and obese persons. This may help inform recommendations for n-3 fatty acid intakes in the reduction of obesity-related disease risk. Article in Journal/Newspaper eskimo* inuits Yup'ik Alaska University of California: eScholarship Gam ENVELOPE(-57.955,-57.955,-61.923,-61.923) European Journal of Clinical Nutrition 65 7 808 817 |
institution |
Open Polar |
collection |
University of California: eScholarship |
op_collection_id |
ftcdlib |
language |
English |
topic |
Erythrocytes Humans Obesity Fatty Acids Omega-3 Docosahexaenoic Acids Eicosapentaenoic Acid Triglycerides C-Reactive Protein Body Mass Index Models Statistical Risk Factors Cross-Sectional Studies Adolescent Adult Aged 80 and over Middle Aged Inuits Alaska Female Male Dyslipidemias Overweight Young Adult Biomarkers EPA DHA generalized additive models Yup'ik eskimos Nutrition & Dietetics Nutrition and Dietetics Human Movement and Sports Sciences Food Sciences |
spellingShingle |
Erythrocytes Humans Obesity Fatty Acids Omega-3 Docosahexaenoic Acids Eicosapentaenoic Acid Triglycerides C-Reactive Protein Body Mass Index Models Statistical Risk Factors Cross-Sectional Studies Adolescent Adult Aged 80 and over Middle Aged Inuits Alaska Female Male Dyslipidemias Overweight Young Adult Biomarkers EPA DHA generalized additive models Yup'ik eskimos Nutrition & Dietetics Nutrition and Dietetics Human Movement and Sports Sciences Food Sciences Makhoul, Z Kristal, AR Gulati, R Luick, B Bersamin, A O'Brien, D Hopkins, SE Stephensen, CB Stanhope, KL Havel, PJ Boyer, B Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids. |
topic_facet |
Erythrocytes Humans Obesity Fatty Acids Omega-3 Docosahexaenoic Acids Eicosapentaenoic Acid Triglycerides C-Reactive Protein Body Mass Index Models Statistical Risk Factors Cross-Sectional Studies Adolescent Adult Aged 80 and over Middle Aged Inuits Alaska Female Male Dyslipidemias Overweight Young Adult Biomarkers EPA DHA generalized additive models Yup'ik eskimos Nutrition & Dietetics Nutrition and Dietetics Human Movement and Sports Sciences Food Sciences |
description |
N-3 fatty acids are associated with favorable, and obesity with unfavorable, concentrations of chronic disease risk biomarkers.We examined whether high eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid intakes, measured as percentages of total red blood cell (RBC) fatty acids, modify associations of obesity with chronic disease risk biomarkers.In a cross-sectional study of 330 Yup'ik Eskimos, generalized additive models (GAM) and linear and quadratic regression models were used to examine associations of BMI with biomarkers across RBC EPA and DHA categories.Median (5th-95th percentile) RBC EPA and DHA were 2.6% (0.5-5.9%) and 7.3% (3.3-8.9%), respectively. In regression models, associations of BMI with triglycerides, glucose, insulin, C-reactive protein (CRP) and leptin differed significantly by RBC EPA and DHA. The GAM confirmed regression results for triglycerides and CRP: at low RBC EPA and RBC DHA, the predicted increases in triglycerides and CRP concentrations associated with a BMI increase from 25 to 35 were 99.5±45.3 mg/dl (106%) and 137.8±71.0 mg/dl (156%), respectively, for triglycerides and 1.2±0.7 mg/l (61%) and 0.8±1.0 mg/l (35%), respectively, for CRP. At high RBC EPA and RBC DHA, these predicted increases were 13.9±8.1 mg/dl (23%) and 12.0±12.3 mg/dl (18%), respectively, for triglycerides and 0.5±0.5 mg/l (50%) and -0.5±0.6 mg/l (-34%), respectively, for CRP.In this population, high RBC EPA and DHA were associated with attenuated dyslipidemia and low-grade systemic inflammation among overweight and obese persons. This may help inform recommendations for n-3 fatty acid intakes in the reduction of obesity-related disease risk. |
format |
Article in Journal/Newspaper |
author |
Makhoul, Z Kristal, AR Gulati, R Luick, B Bersamin, A O'Brien, D Hopkins, SE Stephensen, CB Stanhope, KL Havel, PJ Boyer, B |
author_facet |
Makhoul, Z Kristal, AR Gulati, R Luick, B Bersamin, A O'Brien, D Hopkins, SE Stephensen, CB Stanhope, KL Havel, PJ Boyer, B |
author_sort |
Makhoul, Z |
title |
Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids. |
title_short |
Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids. |
title_full |
Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids. |
title_fullStr |
Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids. |
title_full_unstemmed |
Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids. |
title_sort |
associations of obesity with triglycerides and c-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids. |
publisher |
eScholarship, University of California |
publishDate |
2011 |
url |
http://www.escholarship.org/uc/item/8nw2s21g |
op_coverage |
808 - 817 |
long_lat |
ENVELOPE(-57.955,-57.955,-61.923,-61.923) |
geographic |
Gam |
geographic_facet |
Gam |
genre |
eskimo* inuits Yup'ik Alaska |
genre_facet |
eskimo* inuits Yup'ik Alaska |
op_source |
Makhoul, Z; Kristal, AR; Gulati, R; Luick, B; Bersamin, A; O'Brien, D; et al.(2011). Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids. European journal of clinical nutrition, 65(7), 808 - 817. doi:10.1038/ejcn.2011.39. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/8nw2s21g |
op_relation |
qt8nw2s21g http://www.escholarship.org/uc/item/8nw2s21g |
op_rights |
public |
op_doi |
https://doi.org/10.1038/ejcn.2011.39 |
container_title |
European Journal of Clinical Nutrition |
container_volume |
65 |
container_issue |
7 |
container_start_page |
808 |
op_container_end_page |
817 |
_version_ |
1766403556354555904 |