Novel and potential physiological roles of vacuolar-type H+-ATPase in marine organisms
The vacuolar-type H(+)-ATPase (VHA) is a multi-subunit enzyme that uses the energy from ATP hydrolysis to transport H(+) across biological membranes. VHA plays a universal role in essential cellular functions, such as the acidification of lysosomes and endosomes. In addition, the VHA-generated H(+)-...
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ftcdlib:qt7qk3b2kr 2023-05-15T17:51:08+02:00 Novel and potential physiological roles of vacuolar-type H+-ATPase in marine organisms Tresguerres, M 2088 - 2097 2016-07-15 application/pdf http://www.escholarship.org/uc/item/7qk3b2kr english eng eScholarship, University of California qt7qk3b2kr http://www.escholarship.org/uc/item/7qk3b2kr public Tresguerres, M. (2016). Novel and potential physiological roles of vacuolar-type H+-ATPase in marine organisms. JOURNAL OF EXPERIMENTAL BIOLOGY, 219(14), 2088 - 2097. doi:10.1242/jeb.128389. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/7qk3b2kr pH Soluble adenylyl cyclase Carbonic anhydrase Carbon-concentrating mechanism Ocean acidification Osedax article 2016 ftcdlib https://doi.org/10.1242/jeb.128389 2018-07-13T22:56:42Z The vacuolar-type H(+)-ATPase (VHA) is a multi-subunit enzyme that uses the energy from ATP hydrolysis to transport H(+) across biological membranes. VHA plays a universal role in essential cellular functions, such as the acidification of lysosomes and endosomes. In addition, the VHA-generated H(+)-motive force can drive the transport of diverse molecules across cell membranes and epithelia for specialized physiological functions. Here, I discuss diverse physiological functions of VHA in marine animals, focusing on recent discoveries about base secretion in shark gills, potential bone dissolution by Osedax bone-eating worms and its participation in a carbon-concentrating mechanism that promotes coral photosynthesis. Because VHA is evolutionarily conserved among eukaryotes, it is likely to play many other essential physiological roles in diverse marine organisms. Elucidating and characterizing basic VHA-dependent mechanisms could help to determine species responses to environmental stress, including (but not limited to) that resulting from climate change. Article in Journal/Newspaper Ocean acidification University of California: eScholarship Journal of Experimental Biology 219 14 2088 2097 |
institution |
Open Polar |
collection |
University of California: eScholarship |
op_collection_id |
ftcdlib |
language |
English |
topic |
pH Soluble adenylyl cyclase Carbonic anhydrase Carbon-concentrating mechanism Ocean acidification Osedax |
spellingShingle |
pH Soluble adenylyl cyclase Carbonic anhydrase Carbon-concentrating mechanism Ocean acidification Osedax Tresguerres, M Novel and potential physiological roles of vacuolar-type H+-ATPase in marine organisms |
topic_facet |
pH Soluble adenylyl cyclase Carbonic anhydrase Carbon-concentrating mechanism Ocean acidification Osedax |
description |
The vacuolar-type H(+)-ATPase (VHA) is a multi-subunit enzyme that uses the energy from ATP hydrolysis to transport H(+) across biological membranes. VHA plays a universal role in essential cellular functions, such as the acidification of lysosomes and endosomes. In addition, the VHA-generated H(+)-motive force can drive the transport of diverse molecules across cell membranes and epithelia for specialized physiological functions. Here, I discuss diverse physiological functions of VHA in marine animals, focusing on recent discoveries about base secretion in shark gills, potential bone dissolution by Osedax bone-eating worms and its participation in a carbon-concentrating mechanism that promotes coral photosynthesis. Because VHA is evolutionarily conserved among eukaryotes, it is likely to play many other essential physiological roles in diverse marine organisms. Elucidating and characterizing basic VHA-dependent mechanisms could help to determine species responses to environmental stress, including (but not limited to) that resulting from climate change. |
format |
Article in Journal/Newspaper |
author |
Tresguerres, M |
author_facet |
Tresguerres, M |
author_sort |
Tresguerres, M |
title |
Novel and potential physiological roles of vacuolar-type H+-ATPase in marine organisms |
title_short |
Novel and potential physiological roles of vacuolar-type H+-ATPase in marine organisms |
title_full |
Novel and potential physiological roles of vacuolar-type H+-ATPase in marine organisms |
title_fullStr |
Novel and potential physiological roles of vacuolar-type H+-ATPase in marine organisms |
title_full_unstemmed |
Novel and potential physiological roles of vacuolar-type H+-ATPase in marine organisms |
title_sort |
novel and potential physiological roles of vacuolar-type h+-atpase in marine organisms |
publisher |
eScholarship, University of California |
publishDate |
2016 |
url |
http://www.escholarship.org/uc/item/7qk3b2kr |
op_coverage |
2088 - 2097 |
genre |
Ocean acidification |
genre_facet |
Ocean acidification |
op_source |
Tresguerres, M. (2016). Novel and potential physiological roles of vacuolar-type H+-ATPase in marine organisms. JOURNAL OF EXPERIMENTAL BIOLOGY, 219(14), 2088 - 2097. doi:10.1242/jeb.128389. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/7qk3b2kr |
op_relation |
qt7qk3b2kr http://www.escholarship.org/uc/item/7qk3b2kr |
op_rights |
public |
op_doi |
https://doi.org/10.1242/jeb.128389 |
container_title |
Journal of Experimental Biology |
container_volume |
219 |
container_issue |
14 |
container_start_page |
2088 |
op_container_end_page |
2097 |
_version_ |
1766158187877105664 |