Relationships between plasma adiponectin and body fat distribution, insulin sensitivity, and plasma lipoproteins in Alaskan Yup'ik Eskimos: the Center for Alaska Native Health Research study.
Adiponectin, a protein secreted by adipose tissue, has antiatherogenic, anti-inflammatory, and insulin-sensitizing actions. We examined the relationship between plasma adiponectin and adiposity, insulin resistance, plasma lipids, glucose, leptin, and anthropometric measurements in 316 adult men and...
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ftcdlib:qt6bq9982p 2023-05-15T16:07:27+02:00 Relationships between plasma adiponectin and body fat distribution, insulin sensitivity, and plasma lipoproteins in Alaskan Yup'ik Eskimos: the Center for Alaska Native Health Research study. Goropashnaya, Anna V Herron, Johanna Sexton, Mary Havel, Peter J Stanhope, Kimber L Plaetke, Rosemarie Mohatt, Gerald V Boyer, Bert B 22 - 29 2009-01-01 application/pdf http://www.escholarship.org/uc/item/6bq9982p english eng eScholarship, University of California qt6bq9982p http://www.escholarship.org/uc/item/6bq9982p public Goropashnaya, Anna V; Herron, Johanna; Sexton, Mary; Havel, Peter J; Stanhope, Kimber L; Plaetke, Rosemarie; et al.(2009). Relationships between plasma adiponectin and body fat distribution, insulin sensitivity, and plasma lipoproteins in Alaskan Yup'ik Eskimos: the Center for Alaska Native Health Research study. Metabolism: clinical and experimental, 58(1), 22 - 29. doi:10.1016/j.metabol.2008.09.002. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/6bq9982p Adipose Tissue Humans Insulin Resistance Leptin Blood Glucose Triglycerides Lipoproteins Body Mass Index Skinfold Thickness Linear Models Adolescent Adult Aged 80 and over Middle Aged Inuits Alaska Female Male Adiponectin Cholesterol LDL HDL Waist Circumference Young Adult Endocrinology & Metabolism Clinical Sciences article 2009 ftcdlib https://doi.org/10.1016/j.metabol.2008.09.002 2019-06-28T22:55:19Z Adiponectin, a protein secreted by adipose tissue, has antiatherogenic, anti-inflammatory, and insulin-sensitizing actions. We examined the relationship between plasma adiponectin and adiposity, insulin resistance, plasma lipids, glucose, leptin, and anthropometric measurements in 316 adult men and 353 adult women Yup'ik Eskimos in Southwest Alaska. Adiponectin concentration was negatively associated with body mass index, percentage of body fat, sum of skin folds, waist circumference, triglycerides, insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR]), fasting insulin, and leptin in both men and women, and also with glucose in women. Adiponectin concentration correlated positively with high-density lipoprotein cholesterol concentration, and also with low-density lipoprotein cholesterol in women. Insulin-sensitive individuals (HOMA-IR <3.52, n = 442) had higher plasma adiponectin concentrations than more insulin-resistant individuals (HOMA-IR >or=3.52, n = 224): 11.02 +/- 0.27 microg/mL vs 8.26 +/- 0.32 microg/mL, P < .001. Adiponectin concentrations did not differ between groups of participants with low and high level of risk for developing coronary heart disease. No difference in plasma adiponectin levels was found among Yup'ik Eskimos and whites matched for sex, age, and body mass index. In conclusion, circulating adiponectin concentrations were most strongly associated with sum of skin folds in Yup'ik men and with high-density lipoprotein cholesterol levels, sum of skin folds, waist circumference, and insulin and triglycerides concentrations in Yup'ik women. Article in Journal/Newspaper eskimo* inuits Yup'ik Alaska University of California: eScholarship Metabolism 58 1 22 29 |
institution |
Open Polar |
collection |
University of California: eScholarship |
op_collection_id |
ftcdlib |
language |
English |
topic |
Adipose Tissue Humans Insulin Resistance Leptin Blood Glucose Triglycerides Lipoproteins Body Mass Index Skinfold Thickness Linear Models Adolescent Adult Aged 80 and over Middle Aged Inuits Alaska Female Male Adiponectin Cholesterol LDL HDL Waist Circumference Young Adult Endocrinology & Metabolism Clinical Sciences |
spellingShingle |
Adipose Tissue Humans Insulin Resistance Leptin Blood Glucose Triglycerides Lipoproteins Body Mass Index Skinfold Thickness Linear Models Adolescent Adult Aged 80 and over Middle Aged Inuits Alaska Female Male Adiponectin Cholesterol LDL HDL Waist Circumference Young Adult Endocrinology & Metabolism Clinical Sciences Goropashnaya, Anna V Herron, Johanna Sexton, Mary Havel, Peter J Stanhope, Kimber L Plaetke, Rosemarie Mohatt, Gerald V Boyer, Bert B Relationships between plasma adiponectin and body fat distribution, insulin sensitivity, and plasma lipoproteins in Alaskan Yup'ik Eskimos: the Center for Alaska Native Health Research study. |
topic_facet |
Adipose Tissue Humans Insulin Resistance Leptin Blood Glucose Triglycerides Lipoproteins Body Mass Index Skinfold Thickness Linear Models Adolescent Adult Aged 80 and over Middle Aged Inuits Alaska Female Male Adiponectin Cholesterol LDL HDL Waist Circumference Young Adult Endocrinology & Metabolism Clinical Sciences |
description |
Adiponectin, a protein secreted by adipose tissue, has antiatherogenic, anti-inflammatory, and insulin-sensitizing actions. We examined the relationship between plasma adiponectin and adiposity, insulin resistance, plasma lipids, glucose, leptin, and anthropometric measurements in 316 adult men and 353 adult women Yup'ik Eskimos in Southwest Alaska. Adiponectin concentration was negatively associated with body mass index, percentage of body fat, sum of skin folds, waist circumference, triglycerides, insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR]), fasting insulin, and leptin in both men and women, and also with glucose in women. Adiponectin concentration correlated positively with high-density lipoprotein cholesterol concentration, and also with low-density lipoprotein cholesterol in women. Insulin-sensitive individuals (HOMA-IR <3.52, n = 442) had higher plasma adiponectin concentrations than more insulin-resistant individuals (HOMA-IR >or=3.52, n = 224): 11.02 +/- 0.27 microg/mL vs 8.26 +/- 0.32 microg/mL, P < .001. Adiponectin concentrations did not differ between groups of participants with low and high level of risk for developing coronary heart disease. No difference in plasma adiponectin levels was found among Yup'ik Eskimos and whites matched for sex, age, and body mass index. In conclusion, circulating adiponectin concentrations were most strongly associated with sum of skin folds in Yup'ik men and with high-density lipoprotein cholesterol levels, sum of skin folds, waist circumference, and insulin and triglycerides concentrations in Yup'ik women. |
format |
Article in Journal/Newspaper |
author |
Goropashnaya, Anna V Herron, Johanna Sexton, Mary Havel, Peter J Stanhope, Kimber L Plaetke, Rosemarie Mohatt, Gerald V Boyer, Bert B |
author_facet |
Goropashnaya, Anna V Herron, Johanna Sexton, Mary Havel, Peter J Stanhope, Kimber L Plaetke, Rosemarie Mohatt, Gerald V Boyer, Bert B |
author_sort |
Goropashnaya, Anna V |
title |
Relationships between plasma adiponectin and body fat distribution, insulin sensitivity, and plasma lipoproteins in Alaskan Yup'ik Eskimos: the Center for Alaska Native Health Research study. |
title_short |
Relationships between plasma adiponectin and body fat distribution, insulin sensitivity, and plasma lipoproteins in Alaskan Yup'ik Eskimos: the Center for Alaska Native Health Research study. |
title_full |
Relationships between plasma adiponectin and body fat distribution, insulin sensitivity, and plasma lipoproteins in Alaskan Yup'ik Eskimos: the Center for Alaska Native Health Research study. |
title_fullStr |
Relationships between plasma adiponectin and body fat distribution, insulin sensitivity, and plasma lipoproteins in Alaskan Yup'ik Eskimos: the Center for Alaska Native Health Research study. |
title_full_unstemmed |
Relationships between plasma adiponectin and body fat distribution, insulin sensitivity, and plasma lipoproteins in Alaskan Yup'ik Eskimos: the Center for Alaska Native Health Research study. |
title_sort |
relationships between plasma adiponectin and body fat distribution, insulin sensitivity, and plasma lipoproteins in alaskan yup'ik eskimos: the center for alaska native health research study. |
publisher |
eScholarship, University of California |
publishDate |
2009 |
url |
http://www.escholarship.org/uc/item/6bq9982p |
op_coverage |
22 - 29 |
genre |
eskimo* inuits Yup'ik Alaska |
genre_facet |
eskimo* inuits Yup'ik Alaska |
op_source |
Goropashnaya, Anna V; Herron, Johanna; Sexton, Mary; Havel, Peter J; Stanhope, Kimber L; Plaetke, Rosemarie; et al.(2009). Relationships between plasma adiponectin and body fat distribution, insulin sensitivity, and plasma lipoproteins in Alaskan Yup'ik Eskimos: the Center for Alaska Native Health Research study. Metabolism: clinical and experimental, 58(1), 22 - 29. doi:10.1016/j.metabol.2008.09.002. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/6bq9982p |
op_relation |
qt6bq9982p http://www.escholarship.org/uc/item/6bq9982p |
op_rights |
public |
op_doi |
https://doi.org/10.1016/j.metabol.2008.09.002 |
container_title |
Metabolism |
container_volume |
58 |
container_issue |
1 |
container_start_page |
22 |
op_container_end_page |
29 |
_version_ |
1766403556193075200 |