Potentiation of anticoagulant toxicity to Rattus rattus by two non-steriod anti-inflammatory drugs
In view of resistance reported to have developed towards second generation anticoagulants and the problem of bait shyness and neophobia when acute rodenticides are used, it becomes imperative that methods be evolved to overcome these problems. Attempts to potentiate anticoagulants for effective rode...
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1992
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ftcdlib:qt4293b6zs 2023-05-15T18:04:43+02:00 Potentiation of anticoagulant toxicity to Rattus rattus by two non-steriod anti-inflammatory drugs Sridhara, Shakunthala Krishnamurthy, T. R. 212 - 217 1992-01-01 application/pdf http://www.escholarship.org/uc/item/4293b6zs english eng eScholarship, University of California qt4293b6zs http://www.escholarship.org/uc/item/4293b6zs public Sridhara, Shakunthala; & Krishnamurthy, T. R.(1992). Potentiation of anticoagulant toxicity to Rattus rattus by two non-steriod anti-inflammatory drugs. Proceedings of the Vertebrate Pest Conference, 15(15), 212 - 217. Retrieved from: http://www.escholarship.org/uc/item/4293b6zs BROMADIOLONE BRODIFACOUM ibuprofen phenylbutazone formulation rodenticide bait potentiation rodenticide efficacy Rattus rattus Black rat Life Sciences article 1992 ftcdlib 2019-06-21T22:52:13Z In view of resistance reported to have developed towards second generation anticoagulants and the problem of bait shyness and neophobia when acute rodenticides are used, it becomes imperative that methods be evolved to overcome these problems. Attempts to potentiate anticoagulants for effective rodent control is a new concept with very few studies. Experiments using two non-steroid ant-inflammatory drugs, namely ibuprofen and phenylbutazone at 80 mg/kg and 50 mg/kg body weight respectively to potentiate the action of two second generation anticoagulants, brodifacoum and bromadiolone, yielded positive results for Rattus rattus. The drugs reduced the lethal dose required for 100% mortality as well as days to death. Field trials confirmed laboratory findings. Article in Journal/Newspaper Rattus rattus University of California: eScholarship |
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Open Polar |
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University of California: eScholarship |
op_collection_id |
ftcdlib |
language |
English |
topic |
BROMADIOLONE BRODIFACOUM ibuprofen phenylbutazone formulation rodenticide bait potentiation rodenticide efficacy Rattus rattus Black rat Life Sciences |
spellingShingle |
BROMADIOLONE BRODIFACOUM ibuprofen phenylbutazone formulation rodenticide bait potentiation rodenticide efficacy Rattus rattus Black rat Life Sciences Sridhara, Shakunthala Krishnamurthy, T. R. Potentiation of anticoagulant toxicity to Rattus rattus by two non-steriod anti-inflammatory drugs |
topic_facet |
BROMADIOLONE BRODIFACOUM ibuprofen phenylbutazone formulation rodenticide bait potentiation rodenticide efficacy Rattus rattus Black rat Life Sciences |
description |
In view of resistance reported to have developed towards second generation anticoagulants and the problem of bait shyness and neophobia when acute rodenticides are used, it becomes imperative that methods be evolved to overcome these problems. Attempts to potentiate anticoagulants for effective rodent control is a new concept with very few studies. Experiments using two non-steroid ant-inflammatory drugs, namely ibuprofen and phenylbutazone at 80 mg/kg and 50 mg/kg body weight respectively to potentiate the action of two second generation anticoagulants, brodifacoum and bromadiolone, yielded positive results for Rattus rattus. The drugs reduced the lethal dose required for 100% mortality as well as days to death. Field trials confirmed laboratory findings. |
format |
Article in Journal/Newspaper |
author |
Sridhara, Shakunthala Krishnamurthy, T. R. |
author_facet |
Sridhara, Shakunthala Krishnamurthy, T. R. |
author_sort |
Sridhara, Shakunthala |
title |
Potentiation of anticoagulant toxicity to Rattus rattus by two non-steriod anti-inflammatory drugs |
title_short |
Potentiation of anticoagulant toxicity to Rattus rattus by two non-steriod anti-inflammatory drugs |
title_full |
Potentiation of anticoagulant toxicity to Rattus rattus by two non-steriod anti-inflammatory drugs |
title_fullStr |
Potentiation of anticoagulant toxicity to Rattus rattus by two non-steriod anti-inflammatory drugs |
title_full_unstemmed |
Potentiation of anticoagulant toxicity to Rattus rattus by two non-steriod anti-inflammatory drugs |
title_sort |
potentiation of anticoagulant toxicity to rattus rattus by two non-steriod anti-inflammatory drugs |
publisher |
eScholarship, University of California |
publishDate |
1992 |
url |
http://www.escholarship.org/uc/item/4293b6zs |
op_coverage |
212 - 217 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
Sridhara, Shakunthala; & Krishnamurthy, T. R.(1992). Potentiation of anticoagulant toxicity to Rattus rattus by two non-steriod anti-inflammatory drugs. Proceedings of the Vertebrate Pest Conference, 15(15), 212 - 217. Retrieved from: http://www.escholarship.org/uc/item/4293b6zs |
op_relation |
qt4293b6zs http://www.escholarship.org/uc/item/4293b6zs |
op_rights |
public |
_version_ |
1766176132464377856 |