Polymorphisms in stearoyl coa desaturase and sterol regulatory element binding protein interact with N-3 polyunsaturated fatty acid intake to modify associations with anthropometric variables and metabolic phenotypes in Yup'ik people.
n-3 polyunsaturated fatty acid (n-3 PUFA) intake is associated with protection from obesity; however, the mechanisms of protection remain poorly characterized. The stearoyl CoA desaturase (SCD), insulin-sensitive glucose transporter (SLC2A4), and sterol regulatory element binding protein (SREBF1) ge...
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Language: | English |
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2016
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ftcdlib:qt1wf1p3j4 2023-05-15T18:46:01+02:00 Polymorphisms in stearoyl coa desaturase and sterol regulatory element binding protein interact with N-3 polyunsaturated fatty acid intake to modify associations with anthropometric variables and metabolic phenotypes in Yup'ik people. Lemas, Dominick J Klimentidis, Yann C Aslibekyan, Stella Wiener, Howard W O'Brien, Diane M Hopkins, Scarlett E Stanhope, Kimber L Havel, Peter J Allison, David B Fernandez, Jose R Tiwari, Hemant K Boyer, Bert B 2642 - 2653 2016-12-01 application/pdf http://www.escholarship.org/uc/item/1wf1p3j4 english eng eScholarship, University of California qt1wf1p3j4 http://www.escholarship.org/uc/item/1wf1p3j4 public Lemas, Dominick J; Klimentidis, Yann C; Aslibekyan, Stella; Wiener, Howard W; O'Brien, Diane M; Hopkins, Scarlett E; et al.(2016). Polymorphisms in stearoyl coa desaturase and sterol regulatory element binding protein interact with N-3 polyunsaturated fatty acid intake to modify associations with anthropometric variables and metabolic phenotypes in Yup'ik people. Molecular nutrition & food research, 60(12), 2642 - 2653. doi:10.1002/mnfr.201600170. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/1wf1p3j4 Humans Diabetes Mellitus Type 2 Obesity Cholesterol Stearoyl-CoA Desaturase Fatty Acids Omega-3 Apolipoprotein A-I Anthropometry Diet Cross-Sectional Studies Polymorphism Single Nucleotide Adult Alaska Female Male Glucose Transporter Type 4 Sterol Regulatory Element Binding Protein 1 Glycated Hemoglobin A Alaska Native BMI Gene-by-environment interactions n-3 PUFA Food Science Food Sciences Nutrition and Dietetics Nutrition & Dietetics article 2016 ftcdlib https://doi.org/10.1002/mnfr.201600170 2019-06-28T22:56:27Z n-3 polyunsaturated fatty acid (n-3 PUFA) intake is associated with protection from obesity; however, the mechanisms of protection remain poorly characterized. The stearoyl CoA desaturase (SCD), insulin-sensitive glucose transporter (SLC2A4), and sterol regulatory element binding protein (SREBF1) genes are transcriptionally regulated by n-3 PUFA intake and harbor polymorphisms associated with obesity. The present study investigated how consumption of n-3 PUFA modifies associations between SCD, SLC2A4, and SREBF1 polymorphisms and anthropometric variables and metabolic phenotypes.Anthropometric variables and metabolic phenotypes were measured in a cross-sectional sample of Yup'ik individuals (n = 1135) and 33 polymorphisms were tested for main effects and interactions using linear models that account for familial correlations. n-3 PUFA intake was estimated using red blood cell nitrogen stable isotope ratios. SCD polymorphisms were associated with ApoA1 concentration and n-3 PUFA interactions with SCD polymorphisms were associated with reduced fasting cholesterol levels and waist-to-hip ratio. SLC2A4 polymorphisms were associated with hip circumference, high-density lipoprotein and ApoA1 concentrations. SREBF1 polymorphisms were associated with low-density lipoprotein and HOMA-IR and n-3 PUFA interactions were associated with reduced fasting insulin and HOMA-IR levels.The results suggest that an individual's genotype may interact with dietary n-3 PUFAs in ways that are associated with protection from obesity-related diseases in Yup'ik people. Article in Journal/Newspaper Yup'ik Alaska University of California: eScholarship Molecular Nutrition & Food Research 60 12 2642 2653 |
institution |
Open Polar |
collection |
University of California: eScholarship |
op_collection_id |
ftcdlib |
language |
English |
topic |
Humans Diabetes Mellitus Type 2 Obesity Cholesterol Stearoyl-CoA Desaturase Fatty Acids Omega-3 Apolipoprotein A-I Anthropometry Diet Cross-Sectional Studies Polymorphism Single Nucleotide Adult Alaska Female Male Glucose Transporter Type 4 Sterol Regulatory Element Binding Protein 1 Glycated Hemoglobin A Alaska Native BMI Gene-by-environment interactions n-3 PUFA Food Science Food Sciences Nutrition and Dietetics Nutrition & Dietetics |
spellingShingle |
Humans Diabetes Mellitus Type 2 Obesity Cholesterol Stearoyl-CoA Desaturase Fatty Acids Omega-3 Apolipoprotein A-I Anthropometry Diet Cross-Sectional Studies Polymorphism Single Nucleotide Adult Alaska Female Male Glucose Transporter Type 4 Sterol Regulatory Element Binding Protein 1 Glycated Hemoglobin A Alaska Native BMI Gene-by-environment interactions n-3 PUFA Food Science Food Sciences Nutrition and Dietetics Nutrition & Dietetics Lemas, Dominick J Klimentidis, Yann C Aslibekyan, Stella Wiener, Howard W O'Brien, Diane M Hopkins, Scarlett E Stanhope, Kimber L Havel, Peter J Allison, David B Fernandez, Jose R Tiwari, Hemant K Boyer, Bert B Polymorphisms in stearoyl coa desaturase and sterol regulatory element binding protein interact with N-3 polyunsaturated fatty acid intake to modify associations with anthropometric variables and metabolic phenotypes in Yup'ik people. |
topic_facet |
Humans Diabetes Mellitus Type 2 Obesity Cholesterol Stearoyl-CoA Desaturase Fatty Acids Omega-3 Apolipoprotein A-I Anthropometry Diet Cross-Sectional Studies Polymorphism Single Nucleotide Adult Alaska Female Male Glucose Transporter Type 4 Sterol Regulatory Element Binding Protein 1 Glycated Hemoglobin A Alaska Native BMI Gene-by-environment interactions n-3 PUFA Food Science Food Sciences Nutrition and Dietetics Nutrition & Dietetics |
description |
n-3 polyunsaturated fatty acid (n-3 PUFA) intake is associated with protection from obesity; however, the mechanisms of protection remain poorly characterized. The stearoyl CoA desaturase (SCD), insulin-sensitive glucose transporter (SLC2A4), and sterol regulatory element binding protein (SREBF1) genes are transcriptionally regulated by n-3 PUFA intake and harbor polymorphisms associated with obesity. The present study investigated how consumption of n-3 PUFA modifies associations between SCD, SLC2A4, and SREBF1 polymorphisms and anthropometric variables and metabolic phenotypes.Anthropometric variables and metabolic phenotypes were measured in a cross-sectional sample of Yup'ik individuals (n = 1135) and 33 polymorphisms were tested for main effects and interactions using linear models that account for familial correlations. n-3 PUFA intake was estimated using red blood cell nitrogen stable isotope ratios. SCD polymorphisms were associated with ApoA1 concentration and n-3 PUFA interactions with SCD polymorphisms were associated with reduced fasting cholesterol levels and waist-to-hip ratio. SLC2A4 polymorphisms were associated with hip circumference, high-density lipoprotein and ApoA1 concentrations. SREBF1 polymorphisms were associated with low-density lipoprotein and HOMA-IR and n-3 PUFA interactions were associated with reduced fasting insulin and HOMA-IR levels.The results suggest that an individual's genotype may interact with dietary n-3 PUFAs in ways that are associated with protection from obesity-related diseases in Yup'ik people. |
format |
Article in Journal/Newspaper |
author |
Lemas, Dominick J Klimentidis, Yann C Aslibekyan, Stella Wiener, Howard W O'Brien, Diane M Hopkins, Scarlett E Stanhope, Kimber L Havel, Peter J Allison, David B Fernandez, Jose R Tiwari, Hemant K Boyer, Bert B |
author_facet |
Lemas, Dominick J Klimentidis, Yann C Aslibekyan, Stella Wiener, Howard W O'Brien, Diane M Hopkins, Scarlett E Stanhope, Kimber L Havel, Peter J Allison, David B Fernandez, Jose R Tiwari, Hemant K Boyer, Bert B |
author_sort |
Lemas, Dominick J |
title |
Polymorphisms in stearoyl coa desaturase and sterol regulatory element binding protein interact with N-3 polyunsaturated fatty acid intake to modify associations with anthropometric variables and metabolic phenotypes in Yup'ik people. |
title_short |
Polymorphisms in stearoyl coa desaturase and sterol regulatory element binding protein interact with N-3 polyunsaturated fatty acid intake to modify associations with anthropometric variables and metabolic phenotypes in Yup'ik people. |
title_full |
Polymorphisms in stearoyl coa desaturase and sterol regulatory element binding protein interact with N-3 polyunsaturated fatty acid intake to modify associations with anthropometric variables and metabolic phenotypes in Yup'ik people. |
title_fullStr |
Polymorphisms in stearoyl coa desaturase and sterol regulatory element binding protein interact with N-3 polyunsaturated fatty acid intake to modify associations with anthropometric variables and metabolic phenotypes in Yup'ik people. |
title_full_unstemmed |
Polymorphisms in stearoyl coa desaturase and sterol regulatory element binding protein interact with N-3 polyunsaturated fatty acid intake to modify associations with anthropometric variables and metabolic phenotypes in Yup'ik people. |
title_sort |
polymorphisms in stearoyl coa desaturase and sterol regulatory element binding protein interact with n-3 polyunsaturated fatty acid intake to modify associations with anthropometric variables and metabolic phenotypes in yup'ik people. |
publisher |
eScholarship, University of California |
publishDate |
2016 |
url |
http://www.escholarship.org/uc/item/1wf1p3j4 |
op_coverage |
2642 - 2653 |
genre |
Yup'ik Alaska |
genre_facet |
Yup'ik Alaska |
op_source |
Lemas, Dominick J; Klimentidis, Yann C; Aslibekyan, Stella; Wiener, Howard W; O'Brien, Diane M; Hopkins, Scarlett E; et al.(2016). Polymorphisms in stearoyl coa desaturase and sterol regulatory element binding protein interact with N-3 polyunsaturated fatty acid intake to modify associations with anthropometric variables and metabolic phenotypes in Yup'ik people. Molecular nutrition & food research, 60(12), 2642 - 2653. doi:10.1002/mnfr.201600170. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/1wf1p3j4 |
op_relation |
qt1wf1p3j4 http://www.escholarship.org/uc/item/1wf1p3j4 |
op_rights |
public |
op_doi |
https://doi.org/10.1002/mnfr.201600170 |
container_title |
Molecular Nutrition & Food Research |
container_volume |
60 |
container_issue |
12 |
container_start_page |
2642 |
op_container_end_page |
2653 |
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1766237252329930752 |