CYP2A6 and CYP2B6 genetic variation and its association with nicotine metabolism in South Western Alaska Native people

• Published in: Pharmacogenetics and Genomics
• Main Authors: J. Binnington, M, Zhu, AZX, Renner, CC, Lanier, AP, Hatsukami, DK, Benowitz, NL, Tyndale, RF
• Format: Article in Journal/Newspaper
• Language: English
• Published: eScholarship, University of California 2012
• Subjects: Wilkins; Yupik; Alaska
• Online Access: http://www.escholarship.org/uc/item/10g3w1c6

OBJECTIVES: Alaska Native (AN) people have a high prevalence of tobacco use and associated morbidity and mortality when compared with the general USA population. Variations in the CYP2A6 and CYP2B6 genes, encoding enzymes responsible for nicotine metabolic inactivation and procarcinogen activation,...