Multiple FGF4 Retrocopies Recently Derived within Canids.
Two transcribed retrocopies of the fibroblast growth factor 4 (FGF4) gene have previously been described in the domestic dog. An FGF4 retrocopy on chr18 is associated with disproportionate dwarfism, while an FGF4 retrocopy on chr12 is associated with both disproportionate dwarfism and intervertebral...
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2020
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Online Access: | https://escholarship.org/uc/item/92t773tr https://escholarship.org/content/qt92t773tr/qt92t773tr.pdf https://doi.org/10.3390/genes11080839 |
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ftcdlib:oai:escholarship.org:ark:/13030/qt92t773tr 2024-09-15T18:01:17+00:00 Multiple FGF4 Retrocopies Recently Derived within Canids. Batcher, Kevin Dickinson, Peter Maciejczyk, Kimberly Brzeski, Kristin Rasouliha, Sheida Hadji Letko, Anna Drögemüller, Cord Leeb, Tosso Bannasch, Danika E839 2020-07-01 application/pdf https://escholarship.org/uc/item/92t773tr https://escholarship.org/content/qt92t773tr/qt92t773tr.pdf https://doi.org/10.3390/genes11080839 unknown eScholarship, University of California qt92t773tr https://escholarship.org/uc/item/92t773tr https://escholarship.org/content/qt92t773tr/qt92t773tr.pdf doi:10.3390/genes11080839 public Genes, vol 11, iss 8 Animals Dogs Dog Diseases Retroelements Genetics Population Evolution Molecular Haplotypes Fibroblast Growth Factor 4 Intervertebral Disc Displacement Intervertebral Disc Degeneration Whole Genome Sequencing Canis lupus familiaris FGF4 duplication pseudogene retrocopy retrogene retrotransposition Biotechnology Canis lupusfamiliaris article 2020 ftcdlib https://doi.org/10.3390/genes11080839 2024-06-28T06:28:20Z Two transcribed retrocopies of the fibroblast growth factor 4 (FGF4) gene have previously been described in the domestic dog. An FGF4 retrocopy on chr18 is associated with disproportionate dwarfism, while an FGF4 retrocopy on chr12 is associated with both disproportionate dwarfism and intervertebral disc disease (IVDD). In this study, whole-genome sequencing data were queried to identify other FGF4 retrocopies that could be contributing to phenotypic diversity in canids. Additionally, dogs with surgically confirmed IVDD were assayed for novel FGF4 retrocopies. Five additional and distinct FGF4 retrocopies were identified in canids including a copy unique to red wolves (Canis rufus). The FGF4 retrocopies identified in domestic dogs were identical to domestic dog FGF4 haplotypes, which are distinct from modern wolf FGF4 haplotypes, indicating that these retrotransposition events likely occurred after domestication. The identification of multiple, full length FGF4 retrocopies with open reading frames in canids indicates that gene retrotransposition events occur much more frequently than previously thought and provide a mechanism for continued genetic and phenotypic diversity in canids. Article in Journal/Newspaper Canis lupus University of California: eScholarship Genes 11 8 839 |
institution |
Open Polar |
collection |
University of California: eScholarship |
op_collection_id |
ftcdlib |
language |
unknown |
topic |
Animals Dogs Dog Diseases Retroelements Genetics Population Evolution Molecular Haplotypes Fibroblast Growth Factor 4 Intervertebral Disc Displacement Intervertebral Disc Degeneration Whole Genome Sequencing Canis lupus familiaris FGF4 duplication pseudogene retrocopy retrogene retrotransposition Biotechnology Canis lupusfamiliaris |
spellingShingle |
Animals Dogs Dog Diseases Retroelements Genetics Population Evolution Molecular Haplotypes Fibroblast Growth Factor 4 Intervertebral Disc Displacement Intervertebral Disc Degeneration Whole Genome Sequencing Canis lupus familiaris FGF4 duplication pseudogene retrocopy retrogene retrotransposition Biotechnology Canis lupusfamiliaris Batcher, Kevin Dickinson, Peter Maciejczyk, Kimberly Brzeski, Kristin Rasouliha, Sheida Hadji Letko, Anna Drögemüller, Cord Leeb, Tosso Bannasch, Danika Multiple FGF4 Retrocopies Recently Derived within Canids. |
topic_facet |
Animals Dogs Dog Diseases Retroelements Genetics Population Evolution Molecular Haplotypes Fibroblast Growth Factor 4 Intervertebral Disc Displacement Intervertebral Disc Degeneration Whole Genome Sequencing Canis lupus familiaris FGF4 duplication pseudogene retrocopy retrogene retrotransposition Biotechnology Canis lupusfamiliaris |
description |
Two transcribed retrocopies of the fibroblast growth factor 4 (FGF4) gene have previously been described in the domestic dog. An FGF4 retrocopy on chr18 is associated with disproportionate dwarfism, while an FGF4 retrocopy on chr12 is associated with both disproportionate dwarfism and intervertebral disc disease (IVDD). In this study, whole-genome sequencing data were queried to identify other FGF4 retrocopies that could be contributing to phenotypic diversity in canids. Additionally, dogs with surgically confirmed IVDD were assayed for novel FGF4 retrocopies. Five additional and distinct FGF4 retrocopies were identified in canids including a copy unique to red wolves (Canis rufus). The FGF4 retrocopies identified in domestic dogs were identical to domestic dog FGF4 haplotypes, which are distinct from modern wolf FGF4 haplotypes, indicating that these retrotransposition events likely occurred after domestication. The identification of multiple, full length FGF4 retrocopies with open reading frames in canids indicates that gene retrotransposition events occur much more frequently than previously thought and provide a mechanism for continued genetic and phenotypic diversity in canids. |
format |
Article in Journal/Newspaper |
author |
Batcher, Kevin Dickinson, Peter Maciejczyk, Kimberly Brzeski, Kristin Rasouliha, Sheida Hadji Letko, Anna Drögemüller, Cord Leeb, Tosso Bannasch, Danika |
author_facet |
Batcher, Kevin Dickinson, Peter Maciejczyk, Kimberly Brzeski, Kristin Rasouliha, Sheida Hadji Letko, Anna Drögemüller, Cord Leeb, Tosso Bannasch, Danika |
author_sort |
Batcher, Kevin |
title |
Multiple FGF4 Retrocopies Recently Derived within Canids. |
title_short |
Multiple FGF4 Retrocopies Recently Derived within Canids. |
title_full |
Multiple FGF4 Retrocopies Recently Derived within Canids. |
title_fullStr |
Multiple FGF4 Retrocopies Recently Derived within Canids. |
title_full_unstemmed |
Multiple FGF4 Retrocopies Recently Derived within Canids. |
title_sort |
multiple fgf4 retrocopies recently derived within canids. |
publisher |
eScholarship, University of California |
publishDate |
2020 |
url |
https://escholarship.org/uc/item/92t773tr https://escholarship.org/content/qt92t773tr/qt92t773tr.pdf https://doi.org/10.3390/genes11080839 |
op_coverage |
E839 |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_source |
Genes, vol 11, iss 8 |
op_relation |
qt92t773tr https://escholarship.org/uc/item/92t773tr https://escholarship.org/content/qt92t773tr/qt92t773tr.pdf doi:10.3390/genes11080839 |
op_rights |
public |
op_doi |
https://doi.org/10.3390/genes11080839 |
container_title |
Genes |
container_volume |
11 |
container_issue |
8 |
container_start_page |
839 |
_version_ |
1810438444487278592 |