Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism
Venous thromboembolism (VTE) is a frequent complication in patients with cancer. Homozygous carriers of the fibrinogen gamma gene (FGG) rs2066865 have a moderately increased risk of VTE, but the effect of the FGG variant in cancer is unknown. We aimed to investigate the effect of the FGG variant and...
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ftcdlib:oai:escholarship.org:ark:/13030/qt8xc274th 2024-01-14T10:11:10+01:00 Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism Paulsen, Benedikte Skille, Hanne Smith, Erin N Hveem, Kristian Gabrielsen, Maiken E Brækkan, Sigrid K Rosendaal, Frits R Frazer, Kelly A Gran, Olga V Hansen, John-Bjarne 1963 - 1968 2020-07-01 application/pdf https://escholarship.org/uc/item/8xc274th unknown eScholarship, University of California qt8xc274th https://escholarship.org/uc/item/8xc274th public Haematologica, vol 105, iss 7 Biomedical and Clinical Sciences Oncology and Carcinogenesis Genetics Rare Diseases Cancer Hematology Prevention Clinical Research Aetiology 2.1 Biological and endogenous factors Alleles Fibrinogen Humans Incidence Neoplasms Risk Factors Venous Thromboembolism Cardiorespiratory Medicine and Haematology Immunology Cardiovascular medicine and haematology article 2020 ftcdlib 2023-12-18T19:07:39Z Venous thromboembolism (VTE) is a frequent complication in patients with cancer. Homozygous carriers of the fibrinogen gamma gene (FGG) rs2066865 have a moderately increased risk of VTE, but the effect of the FGG variant in cancer is unknown. We aimed to investigate the effect of the FGG variant and active cancer on the risk of VTE. Cases with incident VTE (n=640) and a randomly selected age-weighted sub-cohort (n=3,734) were derived from a population-based cohort (the Tromsø study). Cox-regression was used to estimate hazard ratios (HR) with 95% confidence intervals (CI) for VTE according to categories of cancer and FGG In those without cancer, homozygosity at the FGG variant was associated with a 70% (HR 1.7, 95% CI: 1.2-2.3) increased risk of VTE compared to non-carriers. Cancer patients homozygous for the FGG variant had a two-fold (HR 2.0, 95% CI: 1.1-3.6) higher risk of VTE than cancer patients without the variant. Moreover, the six-months cumulative incidence of VTE among cancer patients was 6.4% (95% CI: 3.5-11.6) in homozygous carriers of FGG and 3.1% (95% CI: 2.3-4.7) in those without risk alleles. A synergistic effect was observed between rs2066865 and active cancer on the risk of VTE (synergy index: 1.81, 95% CI: 1.02-3.21, attributable proportion: 0.43, 95% CI: 0.11-0.74). In conclusion, homozygosity at the FGG variant and active cancer yielded a synergistic effect on the risk of VTE. Article in Journal/Newspaper Tromsø University of California: eScholarship Tromsø |
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Open Polar |
collection |
University of California: eScholarship |
op_collection_id |
ftcdlib |
language |
unknown |
topic |
Biomedical and Clinical Sciences Oncology and Carcinogenesis Genetics Rare Diseases Cancer Hematology Prevention Clinical Research Aetiology 2.1 Biological and endogenous factors Alleles Fibrinogen Humans Incidence Neoplasms Risk Factors Venous Thromboembolism Cardiorespiratory Medicine and Haematology Immunology Cardiovascular medicine and haematology |
spellingShingle |
Biomedical and Clinical Sciences Oncology and Carcinogenesis Genetics Rare Diseases Cancer Hematology Prevention Clinical Research Aetiology 2.1 Biological and endogenous factors Alleles Fibrinogen Humans Incidence Neoplasms Risk Factors Venous Thromboembolism Cardiorespiratory Medicine and Haematology Immunology Cardiovascular medicine and haematology Paulsen, Benedikte Skille, Hanne Smith, Erin N Hveem, Kristian Gabrielsen, Maiken E Brækkan, Sigrid K Rosendaal, Frits R Frazer, Kelly A Gran, Olga V Hansen, John-Bjarne Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism |
topic_facet |
Biomedical and Clinical Sciences Oncology and Carcinogenesis Genetics Rare Diseases Cancer Hematology Prevention Clinical Research Aetiology 2.1 Biological and endogenous factors Alleles Fibrinogen Humans Incidence Neoplasms Risk Factors Venous Thromboembolism Cardiorespiratory Medicine and Haematology Immunology Cardiovascular medicine and haematology |
description |
Venous thromboembolism (VTE) is a frequent complication in patients with cancer. Homozygous carriers of the fibrinogen gamma gene (FGG) rs2066865 have a moderately increased risk of VTE, but the effect of the FGG variant in cancer is unknown. We aimed to investigate the effect of the FGG variant and active cancer on the risk of VTE. Cases with incident VTE (n=640) and a randomly selected age-weighted sub-cohort (n=3,734) were derived from a population-based cohort (the Tromsø study). Cox-regression was used to estimate hazard ratios (HR) with 95% confidence intervals (CI) for VTE according to categories of cancer and FGG In those without cancer, homozygosity at the FGG variant was associated with a 70% (HR 1.7, 95% CI: 1.2-2.3) increased risk of VTE compared to non-carriers. Cancer patients homozygous for the FGG variant had a two-fold (HR 2.0, 95% CI: 1.1-3.6) higher risk of VTE than cancer patients without the variant. Moreover, the six-months cumulative incidence of VTE among cancer patients was 6.4% (95% CI: 3.5-11.6) in homozygous carriers of FGG and 3.1% (95% CI: 2.3-4.7) in those without risk alleles. A synergistic effect was observed between rs2066865 and active cancer on the risk of VTE (synergy index: 1.81, 95% CI: 1.02-3.21, attributable proportion: 0.43, 95% CI: 0.11-0.74). In conclusion, homozygosity at the FGG variant and active cancer yielded a synergistic effect on the risk of VTE. |
format |
Article in Journal/Newspaper |
author |
Paulsen, Benedikte Skille, Hanne Smith, Erin N Hveem, Kristian Gabrielsen, Maiken E Brækkan, Sigrid K Rosendaal, Frits R Frazer, Kelly A Gran, Olga V Hansen, John-Bjarne |
author_facet |
Paulsen, Benedikte Skille, Hanne Smith, Erin N Hveem, Kristian Gabrielsen, Maiken E Brækkan, Sigrid K Rosendaal, Frits R Frazer, Kelly A Gran, Olga V Hansen, John-Bjarne |
author_sort |
Paulsen, Benedikte |
title |
Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism |
title_short |
Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism |
title_full |
Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism |
title_fullStr |
Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism |
title_full_unstemmed |
Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism |
title_sort |
fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism |
publisher |
eScholarship, University of California |
publishDate |
2020 |
url |
https://escholarship.org/uc/item/8xc274th |
op_coverage |
1963 - 1968 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Haematologica, vol 105, iss 7 |
op_relation |
qt8xc274th https://escholarship.org/uc/item/8xc274th |
op_rights |
public |
_version_ |
1788066052938137600 |